6NZO,2A7O


Conserved Protein Domain Family
SRI

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pfam08236: SRI 
SRI (Set2 Rpb1 interacting) domain
The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilizes the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
Statistics
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PSSM-Id: 400510
View PSSM: pfam08236
Aligned: 105 rows
Threshold Bit Score: 60.9793
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6NZO_S       655 IEKQMKIYENTLFPHVKYVMDKFHGK--LPREDLKKFARDVNKKLVASDYKHNRVQDPTVPLSSKQAKKVRKYVYDFFDR 732 
CCH63102     656 deKLIRTWNKFFAMIVPNMLKKYEKEnhLKHSTAKNLSRDIVKILTKKEVQHNNNRSPPAEITKDKKLKVYKFVNGYMSK 735  Tetrapisispora...
XP_001646388 600 SSHIEHKWNKFFASVVPNLLKKYENEhnISHEHTKHCSREIVKILTSKELKKDPSRAPDEEPTKEKRAKIRDFTTIYMDK 679  Vanderwaltozym...
XP_003683788 614 QEVLEHKWNKYFATFVPNILKKYKDQhnLSHDHIKNCARDIVKTLTAKELKKNADKTPPEKPSSEKLAKVKSFVKGYMEK 693  Tetrapisispora...
XP_002554404 598 gDYMLHKWNRFFAGFVPNLVRHYEKD--LGKDHIKECARDIVKTLSSKELKKDPKKSPPPEPSKEKKAKVREFTKVYMEK 675  Lachancea ther...
CCC71956     633 VNVSEHKWNKFFASFVPNLVRKNVVGvkLSHDHIKECSRDIVKILTSKELKKDDAKSPPEDLTREKKKKTNSFVKVYMEK 712  Naumovozyma ca...
XP_003668303 686 SESNEHKWDNFFASFVPNLVRKNTGDveLSRDHIKECSRDIVKTLTSKELKRDDPKPPPEEATKEKKYKVNKFVKIYMEK 765  Naumovozyma da...
CCK69352     609 SAHIERKWNNFFALFVPNLVRKYTTDvaLNHDYIKQCSRDITKILTNKELRKDPKTLPPSEPDRDKRAKVKKFVNLYMEK 688  Kazachstania n...
CAR29863     590 NHHLEHKWDKFFASFVPGLLRRYEQNegLSHDHAKQCARDIVKILTSKELKKDVTKPPPEEPSKDKRAKVKQFTASYMDK 669  Zygosaccharomy...
XP_003682787 596 TNHVEHKWNKFFASLVPNLLRKYEHDkqISHDSAKQCARDIVKILTSKELKKDVTRSPPDEPTKEKRAKVKQFTQSYMEK 675  Torulaspora de...
6NZO_S       733 ALQKY 737 
CCH63102     736 WFLKE 740  Tetrapisispora blattae CBS 6284
XP_001646388 680 FIQKY 684  Vanderwaltozyma polyspora DSM 70294
XP_003683788 694 FIIKY 698  Tetrapisispora phaffii CBS 4417
XP_002554404 676 FSQKY 680  Lachancea thermotolerans CBS 6340
CCC71956     713 FIEKY 717  Naumovozyma castellii CBS 4309
XP_003668303 766 FITKY 770  Naumovozyma dairenensis CBS 421
CCK69352     689 LVNKY 693  Kazachstania naganishii CBS 8797
CAR29863     670 FLIKY 674  Zygosaccharomyces rouxii
XP_003682787 676 ILQKK 680  Torulaspora delbrueckii
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