Conserved Protein Domain Family
RNA_polI_A34

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pfam08208: RNA_polI_A34 
DNA-directed RNA polymerase I subunit RPA34.5
This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription.
Statistics
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PSSM-Id: 400492
View PSSM: pfam08208
Aligned: 75 rows
Threshold Bit Score: 56.5965
Threshold Setting Gi: 74857228
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007326994  72 EDVEVWVIRVPESIKPKHLEglSFDLDEptsspsrRKKRTTAligslKRKHNSYDIWSLGddhdedqgektteptslIGG 151 Agaricus bispor...
XP_004924280 347 SDDEIFLIKCPSIIDLAAFKgvKINLDK-----------KCKi----KINNQTYECNWDe----------------gKNK 395 domestic silkworm
EDK37676      45 DNREIWLIKTPKGFPIEKLQ--TLPVSFgltskngLNTSAATf----KVENRSFQLYEESfaa------------esEAH 106 Meyerozyma guil...
XP_011273772  28 DKKEIWLIKTPKGFKFDGLT--KIPINF-------NPNGTSLd---fSKDSKNYNIQEDLtnfnsnl---sgksedvSSK 92  Wickerhamomyces...
Q6BWD0        43 NDKEIWLIKTPKGFPLKNLK--TLPVSFta---tsISNGPSRf----NLNQKNFQVNEELlgt------------dtESS 101 Debaryomyces ha...
CCE81586      82 KNKEIWLIKAPKGFQLNKLK--KIPVSFts---tsINNGPDSf----ELDDRKFQVNEEIlsa------------etDNK 140 Millerozyma far...
XP_001527936  50 NDKEVWLIKTPKGFPIHKLK--SLPISFk------kSKKAEAf----EVNDHLFEISEEVtagkqa-----asgdddEDK 112 Lodderomyces el...
CCE41956      45 KDKEIWLIKTPKDFPLEKLK--TLPIAFt------kNRVAEPf----DIVGSTYQVEEELsstsast----iipsteINN 108 Candida parapsi...
Q5AP67        46 KGKEVWLIKTPKGFPLTDLK--KLPISF-------SGKSAESf----KVNNLSYQVTEDLgas-----------asdTNN 101 Candida albicans
XP_002549014  52 KGKEVWLIKAPKGFPLKDLK--TLSVAK-------KNKGNESi----KVNKISYKIDEDFdi-------------dnDSN 105 Candida tropica...
XP_007326994 152 DELkslscLLPRNTKnGKLYAapkPIARHILVSAQPAQPTTTSTDSDsptemVYTNPPRENyPPElLTHRFMPYGSLVKT 231 Agaricus bispor...
XP_004924280 396 IAV-----LSRNKNKtVIKGLp---VNGMLCLRKRIPKLHIREENYM-----INNQNNFIP-LLD-TKCRHPLFGANYKK 460 domestic silkworm
EDK37676     107 KYS-----ILGHKGEnQLEPVe-kTIDRFYNISEKIAIPDINYEKV------VIPRKDVEK-IDG-LVMKHYPTGYGAsd 172 Meyerozyma guil...
XP_011273772  93 YSL-----LIPKETKnGLKIQnslKINKFYNIKESVSIPDINYGKV------IKKRKNIRT-IKG-LKPQHFATGYD-RV 158 Wickerhamomyces...
Q6BWD0       102 KYA-----VLTNENKkNFKIVg-qDISRFYNIRESVDIPSIAMDEV------VKPRKNIKE-IKN-LRMRHFPTGYGAed 167 Debaryomyces ha...
CCE81586     141 KYS-----VFLSEKDgKYLASe-kNFSRFYNIREVVDIPKIDYGKV------VKPRSDVKK-IKN-LRMRHFPSGYGSAD 206 Millerozyma far...
XP_001527936 113 KHT-----IFKAGKSdTFRPTs-yKISRFYNIRETVKIPEINFEEA------VVPRKDVPQ-IEG-LRMRHFPTGYGQKD 178 Lodderomyces el...
CCE41956     109 KHT-----IF-KAKHdSFRPTd-lKISRFYNIKEVVNIPQIDFDKS------RIPREDVPQ-LKR-LRMRHFPTGYGEKD 173 Candida parapsi...
Q5AP67       102 KHT------IFSSKKrSFRPLg-eKISRFYSIHEVVDIPEIQLDKV------VVPRQNVPK-IKK-LRMRHFPTGYGADD 166 Candida albicans
XP_002549014 106 NKH-----TLFASKKaGFKPId-aKISRFYSIHEVVKIPSIDLDKV------VVPRENVQK-VKK-LRMRHFPTGYGAKD 171 Candida tropica...
XP_007326994 232 STDsdndedendtavtsrmdnevvmtevdsnvqsDVAKKEERAIKSSSSKKKDkkvee-eedieVEEERQKEKKEKKKSG 310 Agaricus bispor...
XP_004924280 461 AIKipfsvaerlrevd------qpqdidivdiesEKTKKKKKKKDKIKIETSYvekdneqtnaeELPPKKKSKKHKHTKE 534 domestic silkworm
EDK37676     173 fe----------------------------earaPKRTASHSENGTHKKRKTE-----------SESGEKEKKEKKDKKE 213 Meyerozyma guil...
XP_011273772 159 EEDvasd------------------------aedVEIKDEEKDQDGDLKIDDDe---------aKVEAKKEKKDKKEKKE 205 Wickerhamomyces...
Q6BWD0       168 fde--------------------------akpqgGDVNASDTDSEDDGKIVKK-----------AKIEEKSKSDKKDKKE 210 Debaryomyces ha...
CCE81586     207 YEE-------------------------------ADGKDLSDLDDNSDKEQVS-----------EKKEKNEKKDKKEKKD 244 Millerozyma far...
XP_001527936 179 YGLmaesgkrkknedd------ekeekeeeeeedRSRDIEEGKILKRAKVDKD-----------EGSPRKDKKERKEKKE 241 Lodderomyces el...
CCE41956     174 FKVtyddd----------------------dsdvEEGKAVKRTRKEEPAFDEP-----------HKEKHSSSKHQKENKD 220 Candida parapsi...
Q5AP67       167 YQFdkeeeeeee--------------eesenddvEAGKVLKKAKV-------------------EEKEEKEAKHKKDKKE 213 Candida albicans
XP_002549014 172 YQIdgaqee-------------------esededVSSGKVLKKARVESKPQAD-----------DEEDIKEKKTKKDKKE 221 Candida tropica...
XP_007326994 311 RK----RKGEEG---VSPKKSKKS 327 Agaricus bisporus var. burnettii JB137-S8
XP_004924280 535 TEk------------VKSKKTKQK 546 domestic silkworm
EDK37676     214 KKekkeKKEKKEkkdKKDKKEKKE 237 Meyerozyma guilliermondii ATCC 6260
XP_011273772 206 KKe---KKEKKEkkdKKDKKIKKE 226 Wickerhamomyces ciferrii
Q6BWD0       211 KKe---KKEKKEkkeKKSKKEKKD 231 Debaryomyces hansenii
CCE81586     245 KKd---KKDKKEkkeKKEKKEKKE 265 Millerozyma farinosa CBS 7064
XP_001527936 242 KKe---KKEKKD---KKDKKEKEK 259 Lodderomyces elongisporus NRRL YB-4239
CCE41956     221 KKe---KKEKKEkkeKKEKKEKRE 241 Candida parapsilosis
Q5AP67       214 KKd---KKDKKDkkdKKDKKDKKK 234 Candida albicans
XP_002549014 222 KKd---KKDKKDkkdKKDKKEKKK 242 Candida tropicalis MYA-3404
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