5LSK


Conserved Protein Domain Family
MIS13

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pfam08202: MIS13 
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Mis12-Mtw1 protein family
Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.
Statistics
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PSSM-Id: 369747
View PSSM: pfam08202
Aligned: 10 rows
Threshold Bit Score: 239.721
Threshold Setting Gi: 74608578
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5LSK_D     12 LHLSPQEqsa-----syqDRRQSWRRAsmKETNRRKS-----------LHPIHQGI--TELSRSISVD-LAESKRLGCLL 72 
Q6C761    258 LPLKHTPviqqq-dmrkvPAKTPERNH--DNRGRRISslg-----ngfEGEPHADVdaQNFYKHFEPG-LPEPHKARLLL 328 Yarrowia lipolytica
Q6BRR0    245 MNLEDSDtartr--nqkaPNGKNKRRAsyHNRGKRVLsig-----ngfVGVPHEDVptSDYYKLLDTS-LPEPHRMKQLL 316 Debaryomyces hansenii
Q6CQN5    193 NPLSQNRpil------apEDSRAKRKSfmIQRGRRLSllnqe-nqlndIISPHKDVheSEFYRYMNNS-FAQDLKMKQLM 264 Kluyveromyces lactis
Q6FKQ5    115 IKVIDNEaalk---sslnERARNKRLSl-SQRGRRLSmlstg-vdrhvIVSPHKEVpeQEFYKHVGDLsFGKSLQLRQLF 189 [Candida] glabrata
Q9UUB5     45 LPVSDTPivkrnkelrkgKG----RRSslDQRGKRASsig-----tgfEALPHADVpsHEYYRHISKD-LSEPLRIKQLL 114 Schizosaccharomyce...
XP_961430 233 LPLSDTPiinrnkemrkkGGASGSRRSslGMRGRRASslie----nghSAIPHREVdpSEFYKHIEAEgLSEPRRMRQLL 308 Neurospora crassa ...
Q9H410     78 LHLSPqeqs-----asyqDRRQSWRRAsmKETNRRKS-----------LHPIHQGI--TELSRSISVD-LAESKRLGCLL 138 human
Q9CYC5     76 FHLSPqeqs-----irpqDRRQSWRRAsmKEVNRRKS-----------LAPFHPGI--TELCRSISVK-LAQSQRLGALL 136 house mouse
EIW09829  223 QQLQQPHy---------iQRTRERKKSigSQRGRRLSmlasqanggstIISPHKDIpeEDFYTVVGNAsFGKNLQIRQLF 293 Saccharomyces cere...
5LSK_D     73 LSSFQFSIQKLE----------------------------------PFLRDTKGFSLESFRAKASSLSEELKHFADGLE- 117
Q6C761    329 TWSGKRAMMNHKtrmvresapqg-------------lsetdettarRIVRVIMEDIIRDMKDGKVNTSWYNRPEPDGDDh 395 Yarrowia lipolytica
Q6BRR0    317 IWSFKKKLDQEEklsrsksks----------------ettedqtiiNIAKVIKEEVLRDLIEGQISISWYNRDDNEDET- 379 Debaryomyces hansenii
Q6CQN5    265 NWCLIRALRKLEiknsqn-----------------------ksesrKITLTILKDFVRDIRKGSHDIDWDSEGPEAEPTv 321 Kluyveromyces lactis
Q6FKQ5    190 NWCCDRTYTRIQeadrkktqsqt------------leengsygdpkKITMNIIKSFVHDLKKGTLDIDWEAEEEEEEDDy 257 [Candida] glabrata
Q9UUB5    115 LWASSKALEEQRkkyget----------------------eeaseaAIARSIVQEVLNELLANKVSVSWYQRP------- 165 Schizosaccharomyce...
XP_961430 309 TWCGERALSEKPphgsh------------------------gssaiLGARAIQDQLLKDFGARSEFSDWFAREEAPKPPv 364 Neurospora crassa ...
Q9H410    139 LSSFQFSIQKLE----------------------------------PFLRDTKGFSLESFRAKASSLSEELKHFADGLE- 183 human
Q9CYC5    137 LSSFQFSVEKLE----------------------------------PFLKNTKDFSLECFRAKASSLSEELKHFTDRLG- 181 house mouse
EIW09829  294 NWCLMRSLHKLElkaknqeeegelehltkksklestkaetdyvdpkRLAMVIIKEFVDDLKKDHIAIDWEDEEKYEDEDe 373 Saccharomyces cere...
5LSK_D    118 ----------TDGTLQKcfe----------------------------------------------------------ds 129
Q6C761    396 ----------SNSRFTK--------------------------------------------------------------- 402 Yarrowia lipolytica
Q6BRR0    380 ----------NDNMLTNkev-----------------------------------------------------------t 390 Debaryomyces hansenii
Q6CQN5    322 ---------eDESEISNlfkegntensilvdss---------------------------------lsnknkippiklak 359 Kluyveromyces lactis
Q6FKQ5    258 sg------ngNDTELNAlfddhndgntrhtsarqnltlyddefditlgiqptrpeleyrnnkknnrqstrkrkiqtphkk 331 [Candida] glabrata
Q9UUB5    166 ----------PDAVIPNk-------------------------------------------------------------- 173 Schizosaccharomyce...
XP_961430 365 v------------------------------------------------------------------------------l 366 Neurospora crassa ...
Q9H410    184 ----------TDGTLQKcfe----------------------------------------------------------ds 195 human
Q9CYC5    182 ----------NDGTLQKcfve---------------------------------------------------------ds 194 house mouse
EIW09829  374 ekildntenyDDTELRQlfqenddddddddevdyseiq----------------------rsrrkfserrkalpkepkkl 431 Saccharomyces cere...
5LSK_D    130 nGKASDFSLEASVAEMKEYITKFSLERQTWDQLLlHYQQ---------EAKEIL----SRgs-teAKITEVKVEPMTYlg 195
Q6C761    403 -PNAQNIANAEKLALFKKRLAAQQAEIKEWAKLEaEAREr--------LDMAKGksqkLV-----AQLQKPFDSPPTLps 468 Yarrowia lipolytica
Q6BRR0    391 lPNPLNITNEENIEIFTKKLKSLKQERSQWESSFnRSTSh-------iPNLKIDanqkEAdlqdyCQIRSETQDSSVDfn 463 Debaryomyces hansenii
Q6CQN5    360 iPNEKNIQNKENAKILEEKIKTIKNEIEQWSKDLsDVKI---------PSYELPksqtSI-----VKLPDNLQLTATT-- 423 Kluyveromyces lactis
Q6FKQ5    332 lPNTKNVENEKNLIMLKQKIDILENDINEWANTL-DSHD---------PQKEWQli-------kdVKPDNTTPEQTIT-- 392 [Candida] glabrata
Q9UUB5    174 -PHPQNLKNAQLVDELSAKLTQLHNEEAAWRAVAaNSVS---------SDKSILsfkkAVes-idSKQDLDKQDSPLPpd 242 Schizosaccharomyce...
XP_961430 367 qPNPRNLEHDAKIAELEAKIKRLKEEKKAWQALAkPLPDleplypdsdPAKAPLpepsLLda-eeAKILASLIEPDTAfs 445 Neurospora crassa ...
Q9H410    196 nGKASDFSLEASVAEMKEYITKFSLERQTWDQLLlHYQQ------------EAke-ilSRgs-teAKITEVKVEPMTYlg 261 human
Q9CYC5    195 kEKAADFSLEASVAEVKEYITKFSLERQAWDRLLlQYQN------------EVPpeemPRgs-teTRITEVKVDPAAYlr 261 house mouse
EIW09829  432 lPNSKNVENTKNLSILTSKVNAIKNEVKEWAVTL-DTSR---------PDLEWQeltsFSsq--pLEPLSDTEEPDLA-- 497 Saccharomyces cere...
5LSK_D    196 ssqnevlntkpdyqkilqnQSKVFDCMELVMDELQGSVKQLQ----AFMDESTQCFQ-KVSVQLGKRSMQQLDPSPARK- 269
Q6C761    469 l---------------lsdVALSASTFSRQIDQVEDAVNKINscnvRASKFCDEQFQ-ALDNVLESRSRKRPRQSQDFRt 532 Yarrowia lipolytica
Q6BRR0    464 stvlnnslaekindnynnvNENIPHDVETSTDKLYDASYRLSqareLIAKLQTDKLNdKVSSLVQNYMTKHLREPLSPGt 543 Debaryomyces hansenii
Q6CQN5    424 -------------------KESIHSDFQKRVDGLQETTRLLKsssiLLNETAGMKLQ-RLNGCIVKKRPEDKNS------ 477 Kluyveromyces lactis
Q6FKQ5    393 -------------------NANPVKELEDRLKAMSMNAHLLDstskTLLELSRIKLD-KLRRAYYDTAKNEKKQIE---- 448 [Candida] glabrata
Q9UUB5    243 dap------------elpnISKLKPKFHTLLDMLAENIHTLHsltnAGPEVRSSYG-----RLAAQDFIAHRKSLLSFSk 305 Schizosaccharomyce...
XP_961430 446 sfrr----------rtrsrLQNVQSSLEFKIDHLADSVHKLDmrvsTAGREADQVL-----MLSAARLKEREE----REk 506 Neurospora crassa ...
Q9H410    262 ssqnevlntkpdyqkilqnQSKVFDCMELVMDELQGSVKQLQa----FMDESTQCFQ-KVSVQLGKRSMQQLDPSPARK- 335 human
Q9CYC5    262 ssqkevlstkpdyqrivqdQNQVFAYVELVMDELQGSVKQLQa----LMDESTQYLQ-KVSVQLKKRSMDQLDSSPARK- 335 house mouse
EIW09829  498 -------------------IADVETKLETKVDELRYQSHILNshslALNEITNSKVN-KLNIETMRKISSETDDDHSQVi 557 Saccharomyces cere...
5LSK_D    270 ----------------LLKLQLQNP 278
Q6C761    533 ifnadrfrestldgeqTRDVLRTLS 557 Yarrowia lipolytica
Q6BRR0    544 sswpv-----pnrritTKELLRGIT 563 Debaryomyces hansenii
Q6CQN5    478 ----------------TKKLLRGLS 486 Kluyveromyces lactis
Q6FKQ5    449 ----------------STRLLRGLA 457 [Candida] glabrata
Q9UUB5    306 y-------------vdTMNLLRLLS 317 Schizosaccharomyces pombe 972h-
XP_961430 507 grvg-------trdlpTIEVLRSLG 524 Neurospora crassa OR74A
Q9H410    336 ----------------LLKLQLQNP 344 human
Q9CYC5    336 ----------------LLKLPLQSS 344 house mouse
EIW09829  558 ---------------nPQQLLKGLS 567 Saccharomyces cerevisiae CEN.PK113-7D
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