Conserved Protein Domain Family
PIH1

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pfam08190: PIH1 
pre-RNA processing PIH1/Nop17
This domain is involved in pre-rRNA processing. It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae. The C-terminal region of this family has similarity to the CS domain pfam04969.
Statistics
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PSSM-Id: 369738
View PSSM: pfam08190
Aligned: 15 rows
Threshold Bit Score: 189.445
Threshold Setting Gi: 124466726
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBZ13064      55 LRTLQSRlqeeatKEAKEDLEQVHSDEQ-GQ-WMFVLPDPGFCIKTNVAGGa----KVFINVCQHARIGEPvpmEPENGS 128 Leishmania majo...
Q0P4V4        38 ISDPENR------KKYEQEIYKMENERG-MD-IKFIHPKPGYVLLSSVNGVq----KCYLNICSNDLIQKP---EFKPGK 102 tropical clawed...
Q9NVR5        43 LTDPENR------RRYEAEITALERERG-VE-VRFVHPEPGHVLRTSLDGAr----RCFVNVCSNALVGAP---SSRPGS 107 human
CAG10513      40 LADPENR------RRYEEEIKILEQNRG-NT-IEFIHPEPVKALRTCMNGSq----KCYINICASEKIGKP---SCSPKV 104 spotted green p...
A0DMA1        44 ISDPKNR------EEYDQYLKQLERESElPKgMKLIKPEPHFCVKTSICKEitlqfKFFINICSTSVIDKP-----QSET 112 Paramecium tetr...
Q4DT93        46 LRDIQMRiqeesrNAMKSKLEAIQSDEN-GQ-WMYVLPEPGFCVKCTTSGGg----KIFLNVCQHERIAEPipmEEDEKT 119 Trypanosoma cruzi
Q38DW7        46 LADLQKKiqeesmKSAKAKLEEIHSDEN-GQ-WMYILPEPGFCVKCKVAGGg----KVFVNVCKHERIAEPipiDDDNEA 119 Trypanosoma brucei
A0CTY4        36 LTDPEYL--------KLKDIQEYLDQEG----GMMIEPTPHFVLKAFDQNGe----KVFFNVTAHSVVDAP---EEKQLI 96  Paramecium tetr...
Q9VK57        30 INQYFGG------ADPEGS-GPQQKPPP-RD-SLIVQPTAGICVKSFKTNSd---eKFFINVCQAAEVPAPqdvTEEELI 97  fruit fly
XP_001629864  38 ISDPENK------KRYEEEIRQMENERG-MD-VKFVNPEEGFVVKTTRETDg---iKAFVNICYNQHIEKAtfrMAEKGD 106 starlet sea ane...
CBZ13064     129 AGQgDTA-EMRYRIPISCGQARPGKDKGGKPCKVYDVIVNPSTMQRCGKDHEFRRFVAALCMQWIKQKS---EPTLNadE 204 Leishmania majo...
Q0P4V4       103 DGE-GKA-GLHWSLPYSLSPGRDDLSKDWSKHVIYDVVFHPDTLHIASKNGKFKGIVDSTALEAVASQF---NVTLDkaN 177 tropical clawed...
Q9NVR5       108 GGDrGAApGSHWSLPYSLAPGREYAGRSSSRYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQF---GVKLDrrN 184 human
CAG10513     105 LED-GRG-TLCWALPHILHPKKQELYRKGHKVTIYDVVFHPETLDLASKNKTFLDMVHDTAIQGIQSAF---SVSLDrnG 179 spotted green p...
A0DMA1       113 ITQnGQT-GQNWKIPYSIGKIRYDQDKKQNICNTVDVAFHPTTIGLCYKTPNFKNLVCSTALEASGKQLgerNEEISk-D 190 Paramecium tetr...
Q4DT93       120 D-------EIKFKIPLSCGQARPGTDKSGKPCKVYDVIVNPSTVQRCSKDHEFRCFVVSLCIHWIKQKC---EPTLNheE 189 Trypanosoma cruzi
Q38DW7       120 --------EVKFRIPLSCGQARAESDKSGKPCKVYDVIVNPSTIHRCTQDHDFRCFVISLCIHWIQQKS---EPTLNlqE 188 Trypanosoma brucei
A0CTY4        97 DYNn----EVGIRVPMSVGSIKEDHDVKGDTCKVIDLVINPTVATNLTQDDNLKTFFCQLVQTYVDQKY---KLKLQd-K 168 Paramecium tetr...
Q9VK57        98 GILeSTT-PGSYRVPMSISDPRFTKDRSDKTVDVCDIAINPKFLVKIQKSQLFKNFFMQIVIEAMSEKY---NVQLNmeK 173 fruit fly
XP_001629864 107 GTE-RKK-GQQWSIPYSLAQPRDDFDRAGKKCVTFDVVFHPDTYKKCTKMPQFKKMVIETALEGIERQL---NIKLNkkN 181 starlet sea ane...
CBZ13064     205 FRNL-SFKCKG-KLEPQRIRLSTQPKE 229 Leishmania major strain Friedlin
Q0P4V4       178 VRTL-SMKYKG-VPNPSVLRKPLPEAS 202 tropical clawed frog
Q9NVR5       185 AKTL-KAKYKG-TPEAAVLRTPLPGVI 209 human
CAG10513     180 VKEI-RAKCKG-TPQTCVIRKPIPGYQ 204 spotted green pufferfish
A0DMA1       191 FKVLkHTKCKGgEPALLPVRIDKKGKL 217 Paramecium tetraurelia
Q4DT93       190 YRSM-NFKVKG-DLEPQRIRLSTAPKG 214 Trypanosoma cruzi
Q38DW7       189 YRNM-SFRVKG-TLEPQRIRLSTTPKV 213 Trypanosoma brucei
A0CTY4       169 FISL-KMKYKGkSVQFQRVKGKKPPKV 194 Paramecium tetraurelia
Q9VK57       174 TIILnNRKFIG-TLVTHRVRNEDMKRA 199 fruit fly
XP_001629864 182 LKFP-KMKFKG-MKQATVIRNKSNEns 206 starlet sea anemone
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