1HM3,1N7Q


Conserved Protein Domain Family
Lyase_8_N

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pfam08124: Lyase_8_N 
Polysaccharide lyase family 8, N terminal alpha-helical domain
This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.
Statistics
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PSSM-Id: 400444
View PSSM: pfam08124
Aligned: 14 rows
Threshold Bit Score: 343.181
Threshold Setting Gi: 14278192
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HM3_A           26 G----TAELiMKRVMLDLKKPLRNMDKVAEknln------tlqpDGSWKDVPy-------KDDAMTNWlpNNHLLQLETI 88   Pedobacter ...
Q5DYT2           47 WaenyLGDP-AITFDQTLKNMVTSTNSSAQkhwdsm--tpqpnaSGIWDDLPli----dkDTTLGPNI--RNSYQRLFTM 117  Aliivibrio ...
Q99ZX4           77 WnsiiAGNDaYDKTNPDMVTFHNKAEKDAQniiksyqgpdhenrTYLWEHAK--------DYSASANI--TKTYRNIEKI 146  Streptococc...
Q7MP30           51 WasyfLGDQ-TMAFDQQLTNEITKINHQAKqwldq----ltideNGLWADLPlqtdnaeqKRKLGIQL--YATYQRIFTL 123  Vibrio vuln...
Q7MP31           73 Wm-------------QQFQSSRTNVN------------------AGLWLDLPlatateqdKKQLGDQL--YKSYQRLFTM 119  Vibrio vuln...
Q82ZM8          271 WkmrlLGTTqYD-NDADVQQYRAQIATESLalwqtl--nqaadrEYLWERKP--------SDTVSADY--TTQFTNIKKL 337  Enterococcu...
Q837L8          241 WrnqlVSKE-YDSTNQALVDYVQKISNEATeldqtm--nkepnrSYLWPLEP--------GNTPSADL--TTQFTKLQKL 307  Enterococcu...
Q82JQ0           45 WlvlaLGAG-YDPTAEPYASRLRRTGELARgyrat----mapaaASLWPGHP---------FDPPSGI--TQSYSRLWTM 108  Streptomyce...
tigr:AAur_3068   40 RrrlvLTGGrSAADIPELAAQLEGMGKTAEkwwtsm--dkttarTSLWSDIPltg--igqSTAATGNM--GLHFNRLYDM 113  Paenarthrob...
P0CZ01           46 WidiiTGRRaARTSDPRARAIIAKTDRKVAeiltdlvsgssrqtVLISADLR---------KEQSPFI--TKTARAIESM 114  Cutibacteri...
1HM3_A           89 IQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSR-------------NWWHNEIATPQALGEMLILMRYGKKpldEAL 155  Pedobacter ...
Q5DYT2          118 AKAYRLRDGNLENNQLMLNDIMTAMNYINQNFYFVNqle--------ygNWWQWELAIPKDIHNILVLLFDDIKdnyQTI 189  Aliivibrio ...
Q99ZX4          147 AKQITNPESCYYQDSKAIAIVKDGMAFMYEHAYNLDrenhqttgkenkeNWWVYEIGTPRAINNTLSLMYPYFT---QEE 223  Streptococc...
Q7MP30          124 ARAYKLPGGELENDPQLLAMLVESLAFLHDNFYHVGtae--------wgNWWHWQLGIGRVANNTLVVLYDELP---QEI 192  Vibrio vuln...
Q7MP31          120 AQAYQLPKSDLYQSVELLDVITEGLAILNQHFYKVGvee--------wgNWWHWQLGISRVANNILVLMYQELP---ASL 188  Vibrio vuln...
Q82ZM8          338 ALGYYEPSSELFEKPEVYDAIVKGIEFMIDTKKYNGtyy--------tgNWWDWQIGSAQPLTDTLILLHDDLLntdAEK 409  Enterococcu...
Q837L8          308 ALAYGTKGSTLYQDDKLAATIIDGLDFMVTQKGYDGkky--------hgNWWDWQIGVPQKFLNILMILEDKVS---PEK 376  Enterococcu...
Q82JQ0          109 TQAYVQEGTGSTGDAGLLADIVRGLDHVSATVYNPTttr--------ygNWWEWQIGSPRLLMDIVAALHDRLS---AAR 177  Streptomyce...
tigr:AAur_3068  114 ALGYAVPGNPFAGNPALAADIVAGLQLLSSTAYKPStka--------agNWWFWEIGVPRKTVDILTLLHAEVP---EAL 182  Paenarthrob...
P0CZ01          115 ACAWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSqde--------ygNWWDWEDGASRAVADVMCILHDVLP---PEV 183  Cutibacteri...
1HM3_A          156 VHKLTERMKRGEPEK----------------------KTGANKTDIALHYFYRALLTSDEALLSFAVKELFY-------- 205  Pedobacter ...
Q5DYT2          190 ITNHLNATRYFTPDPthlgvspgaa---estnpnyreSTGGNRTDNAQVVLIRGMLENNSEEISQAIAALPA-------- 258  Aliivibrio ...
Q99ZX4          224 ILKYTAPIEKFVPDPtrfrvra--------anfspfeANSGNLIDMGRVKLISGILRKDDLEISDTIKAIEK-------- 287  Streptococc...
Q7MP30          193 ISNYVDASRYFVPRPthlsegygap---yssaplmfeSTGGNRTDNAQVVLIRGILDNNENEIKSAVESLSS-------- 261  Vibrio vuln...
Q7MP31          189 VTNYIDAIEYFVPNPthlsegagas---assmprpfeSTGANRVQNVQVVLVRALLANDQDAFQTAVDALEP-------- 257  Vibrio vuln...
Q82ZM8          410 LNKFTAPLMLYAKDPniqw--------------piyrATGANLTDISITVLGTGLLLEDNQRLVQVQEAVPS-------- 467  Enterococcu...
Q837L8          377 QQIYTNALSSYVPDPfkqlytkpqgtfvdlafipnfvTSGANRTDLALTVLGLGILQKDSGKINQASSSIVD-------- 448  Enterococcu...
Q82JQ0          178 RAAACAAVGHFIPDDmlrd--------------ysgtSTGANRVDLCRGVALSGILGRAPDRIALARDALSP-------- 235  Streptomyce...
tigr:AAur_3068  183 RTSLLAAVRWFAPNPnwrgr------------atslaETGANRVDKSLACCMRGILDNNVGDIALGRDALSDtvrggtns 250  Paenarthrob...
P0CZ01          184 MSAAAAGIDHFIPDPwfqqpasvkp---tanpvqpvvSTGANRMDLTRAVMCRSIATGDEKRLRHAVDGLPD-------- 252  Cutibacteri...
1HM3_A          206 PVQFVHYeEGLQYDYSYLQH-----------GPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLK 274  Pedobacter ...
Q5DYT2          259 VIEYVSEgDGYYTDGSFLQH-----------SDIAYNGTYGNVLLGGLGIQMNAVAGSPWSMDNQTISNVYNIINQSYEP 327  Aliivibrio ...
Q99ZX4          288 VFTLVDEgNGFYQDGSLIDHvvtnaqsplykKGIAYTGAYGNVLIDGLSQLIPIIQKTKSPIKADKMATIYHWINHSFFP 367  Streptococc...
Q7MP30          262 IIPFVTEgDGFYQDGSFIQH-----------KDLPYSGTYGQVMVEGLGMLMGLVANTPWQANDPNLQKIYPLLLEAFAP 330  Vibrio vuln...
Q7MP31          258 VITFVESgDGFYSDGSFIQH-----------TDIPYNGSYGNELLEGLGLLLGTIASAPWNEQTEQYSAIYSLLLEAYAP 326  Vibrio vuln...
Q82ZM8          468 VLKSVSSgDGLYPDGSLIQH-----------GYFPYNGSYGNELLKGFGRIQTILQGSDWEMNDPNISNLFNVVDKGYLQ 536  Enterococcu...
Q837L8          449 VFKLVTKgDGFYQDGSFIQH-----------NNIPYTGSYGNVLVKGVGQILAITADSSFQMDATLVTEFVENVDRAFLP 517  Enterococcu...
Q82JQ0          236 VFPYVTQgDGLYADGSFVQH-----------TWVAYSGTYGQVLLDGLGRLFSLFAGSTWDVTDPNRQIILDSVEQAYAP 304  Streptomyce...
tigr:AAur_3068  251 VFTYVSSgDGFYADGSYVQH-----------SYLPYAGTYGVVALAGIAEIIAMLGGSSWAINDPKRTVLLDAVEDTYAP 319  Paenarthrob...
P0CZ01          253 AWRVTTEgDGFRADGGFIQH-----------SHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIVESARKAFHDQVERGFIP 321  Cutibacteri...
1HM3_A          275 AIRGSYMDFNVEGRGVSRPDIL---------NKkaEKKRLLVAKMIDLk-hTEEWADaiaRTDSTVAA 332  Pedobacter heparinus
Q5DYT2          328 LLYKGAMMDMVNGRSISRSAEQ---------NH--DVGLNIVNSMLFYtngPDSDKNk--QLSSLIKT 382  Aliivibrio fischeri ES114
Q99ZX4          368 IIVRGEMMDMTRGRSISRFNAQ---------SH--VAGIEALRAILRIadmSEEPHRl--ALKTRIKT 422  Streptococcus pyogenes ...
Q7MP30          331 LLVDGKMMDMVNGRAISRISGQ---------NQ--KVGQAMLSSMLLYlpgAPENYKq--QLGEFLKS 385  Vibrio vulnificus YJ016
Q7MP31          327 FLVDGRMMDMVNGRAVSRLSGQ---------NH--KIGHAVLNSMLFFiesAPSNVKk--QLQSVIKT 381  Vibrio vulnificus YJ016
Q82ZM8          537 LMVNGKMPSMVSGRSISRAPETnpf----ttEF--ESGKETIANLTLIakfAPENLRn--DIYTSIQT 596  Enterococcus faecalis
Q837L8          518 LIYKGEMLPTVNGRSISRAPAV---------GKt-GYGSTTMYNLLIVakfAPNNYQk--KFQEAVKY 573  Enterococcus faecalis
Q82JQ0          305 LIHDGLVMDSVNGRAISRGYLKsddlhvmrgDH--FHGQALIAAIALLaggAGPQERa--RWHARIKG 368  Streptomyces avermitilis
tigr:AAur_3068  320 FVWDGRIMDTIRGRAVSRQREP---------DY--VSGFGLISAVLLLapgCEEPYRs--RFLALAKG 374  Paenarthrobacter auresc...
P0CZ01          322 VMYNGQILDDVRGRSISRINES---------AA--MHGISIARAMLMMadaLPTHRAe--QWRGIVHG 376  Cutibacterium acnes KPA...
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