Conserved Protein Domain Family
Cnn_1N

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pfam07989: Cnn_1N 
Centrosomin N-terminal motif 1
This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organising activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.
Statistics
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PSSM-Id: 400377
View PSSM: pfam07989
Aligned: 84 rows
Threshold Bit Score: 36.7287
Threshold Setting Gi: 387593272
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKG13276             116 REQQTNMDKMSKDNFDLKLRLtlveershrleAELEDALEKIDTlrvveEERDELHEENINLCDRVEDLQQSKEACEEKL 195  Macrop...
WGS:AFWA:PNEG_00239  226 REQSNVIDSLRKEKWDLQMKV-----------FFLQQYRDRSRD-----ESVEEIIKQNIELATTVRELSKTNKNLKRII 289  Pneumo...
CCG80674             204 KESSAQIDALLNENWGLKMKI-----------MFMDQHFEQDRE-------KAELIAENVRLQTNGFNFVQQVKARDKTI 265  Taphri...
Q0U191               510 KEQNSKIDKLSKENFDLKLKI-----------HFLDQALQNRSD-----EGVKDMISKNVQLQTDLATEKKETQSLRKKL 573  Parast...
EGP83442             364 KEQNSKIDKLTKENFDLKLKI-----------HFLDQALQNRSD-----DGVRELIEKNVQFQTDLANERKEAQSLRKKM 427  Zymose...
EME78075               4 KEQNAKTDALTKENFDLKLKI-----------HYLSEALHKHSE-----EGVDELIATNVQLQTDLANERKDANALRKKL 67   Pseudo...
EMF08814             164 KEQNAKMDALTKENFDLKLKI-----------HFLSQALQNRSE-----DGIKELVDTNVQLQTDLANERKENATMRKRM 227  Sphaer...
EME39757              37 KEHTKHLDTLTKENFDLKLKI-----------TFLEDAIRTRSQ-----DGVEDLINQTVSLQTELAHERRETQSMRRKV 100  Dothis...
EAY04411             351 KKQDEAIKNLQKENENLKNEI-----------KILEENQKSGEN-----DGWGDDEDENTELKNQIDQLKKENDNLKKQI 414  Tricho...
XP_004202163         117 KELQGESQKLETENYNLKIKL-----------ATLTRFLDQTPE------EQRELLSQNVELKQQILQLTREIQTLKDSV 179  Pichia...
EKG13276             196 RDSWK 200  Macrophomina phaseolina MS6
WGS:AFWA:PNEG_00239  290 RDMEM 294  Pneumocystis murina B123
CCG80674             266 RSLQK 270  Taphrina deformans PYCC 5710
Q0U191               574 RDLER 578  Parastagonospora nodorum SN15
EGP83442             428 KEMEK 432  Zymoseptoria tritici IPO323
EME78075              68 REYET 72   Pseudocercospora fijiensis CIRAD86
EMF08814             228 RDMEM 232  Sphaerulina musiva SO2202
EME39757             101 RTLEQ 105  Dothistroma septosporum NZE10
EAY04411             415 QNLQT 419  Trichomonas vaginalis G3
XP_004202163         180 RDLNf 184  Pichia farinosa CBS 7064
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