Conserved Protein Domain Family
COPIIcoated_ERV

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pfam07970: COPIIcoated_ERV 
Endoplasmic reticulum vesicle transporter
This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.
Statistics
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PSSM-Id: 400361
View PSSM: pfam07970
Aligned: 163 rows
Threshold Bit Score: 153.518
Threshold Setting Gi: 154415829
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX05200     141 CYGATPPQhaiktGCCNTCDEVREAYASSSWAFGKGENVEQCQrehyaeriDEQRH--EGCRIEGGLRVNKVVGNFHIAP 218 Grosmannia clav...
XP_001313964 144 CYGALPQG-----KCCNSCEDVINAFKAKGWGIDGIDRWQQCIdegyadlgK------ESCNVYGDINVAHISGFLYFA- 211 Trichomonas vag...
EAX96852     122 CYGTEFAEg---sRCCNTCEDVVSHHIKAGRPLTNVTTWQQCIn------eKYDFTgkEKCQIFGNHHVSAIDGGIRILP 192 Trichomonas vag...
XP_001299739 123 CYGAESSQr----KCCQTCEDVVAAYQEKGWGIGNLSSWAQCRa------eGVMFDgkERCQAYGNLHVNAIEGGFHLAP 192 Trichomonas vag...
XP_001295947 103 CYDFYDNR-----FCCNGCEKLKEIYHSNNKTAT-PENWTQCKpe-----nKQKFDpnEKCHVKGKISVNRVPGSFHLAI 171 Trichomonas vag...
XP_001308935 130 CFKVQFHNy----TCCNGCDRLKENYKLNNLTPE-PEKWPQCQtn-----aRPDINssEKCLVKGKVSVNRVRGSFHIAA 199 Trichomonas vag...
XP_001307985 130 CYNLSTNPd----ECCNSCLKVQLLSLMQNKPVD-FSKYRVCNnye--kkpNVSLS--EKCLVKGKLTVNRIPGSFHIAP 200 Trichomonas vag...
EAY00488     145 CYNAKDPKr----ICCRSCQEVFDAYRDAAFKPPVLTEIEQCKpv----aeKVAKMegEGCKVDASFKALRVASEMHIAP 216 Trichomonas vag...
XP_001310077 130 CYGQKS-------GCCNTCKEVRKAFKANNRPPPPIIHIQQCVdeg--ykeELIAMkgEACRVHGTLTVHRAPGTFHVAP 200 Trichomonas vag...
EAX90096      18 CYGASN-------GCCNSCKEVLDAFQKIEKSHPPTAMIQQCRnt----fsDADSLinDSCTLGITLTVPHTHGSFFITI 86  Trichomonas vag...
EFX05200     219 GRSFSN--GN------MHV--------HDL--KNYWdmptpnLHSFTHTVHSLRFG-PQLPESLqktlagggakgqpwtn 279 Grosmannia clav...
XP_001313964 212 --------LEdykvgdKHPkdis-rlsH--------------KYNLTHTINYLEFG-PRVSHEP---------------- 251 Trichomonas vag...
EAX96852     193 RFSSNEepf-------------------------------tkLLNLTHYIDHITFGtSFGP------------------- 222 Trichomonas vag...
XP_001299739 193 GINVFSr--------fGHV--------Hdfsp-------lvdTLNLTHEIEHISFG-APIDK------------------ 230 Trichomonas vag...
XP_001295947 172 GQSIED--YG-------HQ--------Hilld-------dyqTITFDHDIIDLRFG-ANIPMTS---------------- 210 Trichomonas vag...
XP_001308935 200 GRNIYLndGS-------HI--------Helld-------dfpNLAFSHAIEHIRFG-PRIITAK---------------- 240 Trichomonas vag...
XP_001307985 201 GTNVPQs---------AYL--------Hdlss-------mqmFHDMTHSIQRLRFG-PHIPRTS---------------- 239 Trichomonas vag...
EAY00488     217 GYSWNS--EG------WHV--------HDLslFTKEf----aSLNLTHTIHYLSFSeKEGD------------------- 257 Trichomonas vag...
XP_001310077 201 GESYNIngEH------DHYyedlginiD--------------EMNFSHTINHFSIGmPTANSY----------------- 243 Trichomonas vag...
EAX90096      87 GQNTTNtsADylgv-------------------------pkeNLNFTHSFDFFSMGgg---------------------- 119 Trichomonas vag...
EFX05200     280 hhiNP---LDGVm--QQTSDPNFNYMYFIKIVPTSYLAL-GWektfrgfvddhdsadvgsyglladgsveTHQ----YSV 349 Grosmannia clav...
XP_001313964 252 ---GP---LDGLt-vLQEEPGLMQYNYDLEVVPTKWFSSrGFpv-------------------------sTYK----FHP 295 Trichomonas vag...
EAX96852     223 ---QP---LDDAl-iVQSEPGQFHYRYDLKAVPTVMHNQdGSit-------------------------hGFQ----YAV 266 Trichomonas vag...
XP_001299739 231 ---SP---LDNTr-vVQKKPGQIHYRYNLKAVPTVKEVNgKvh--------------------------rFFR----FTV 273 Trichomonas vag...
XP_001295947 211 ---HP---LRGTh--IKSTGEPLATEYNLIITPIVFYADgQYie-------------------------kGFEyvyfYSM 257 Trichomonas vag...
XP_001308935 241 ---QP---LQNLv-mRAKENLTVTHDYSLLVTPVIFVADnQFie-------------------------kSFE----YTV 284 Trichomonas vag...
XP_001307985 240 ---NP---LDNFksfQQIPTHDRTYFYNLLITPVIFYRDgVEyl-------------------------kGYE----YTA 284 Trichomonas vag...
EAY00488     258 ---YP---LNNLn-nVQTENGAWRVVYTADILEGNYSAS-------------------------------KYQmynpKSF 299 Trichomonas vag...
XP_001310077 244 ---YP---LDGHt-eIQQKTGRMKMIYFLRAVPINLDGR-------------------------------VFS----FGA 281 Trichomonas vag...
EAX90096     120 --yHPaqiLQNYm-kVQKEYGRYKAMYYIRATRil----------------------------------nDYDtqysLSV 162 Trichomonas vag...
EFX05200     350 TSHKRSLQGGDDAaeghqerlharggIPGVFFSYDISPMKVVNREERAkTFAGFLAGLCAIIGGTLTVAAAVD 422 Grosmannia clavigera k...
XP_001313964 296 MITQKNFTEKVNRg------------VPGIFLNYNLAPISLVQYEVIS-SPWKLITSVCAIVGGCFTCVSLAD 355 Trichomonas vaginalis G3
EAX96852     267 DSAKIPITDRTRL-------------GEGIFFNYYFATVAVVGKPDRF-TIYILISRLFCIFGGGFFLARLID 325 Trichomonas vaginalis G3
XP_001299739 274 NYAEIPVTARGRY-------------GPGIFFVYSFAPVAITSTYDRP-NITVLLARLISIFGGSFMLARLID 332 Trichomonas vaginalis G3
XP_001295947 258 TYHL----------------------VPGIYFYYSFTPYTIAVTWQSR-SFRSFLISTGGLLSGIYAIFSMVs 307 Trichomonas vaginalis G3
XP_001308935 285 YLHPVQDK------------------DPGIYFDYQFTPYTIQITWISR-SFRGFLISTAGFTAGLYAIASIID 338 Trichomonas vaginalis G3
XP_001307985 285 FSEAIDTFQLFGI-------------SPGLFFQYQFTPYTIVVSANRQ-NFLQFISNTFGVISGIYACLSILD 343 Trichomonas vaginalis G3
EAY00488     300 --------------------------ASGLFFKYDVSPISAVTYTDSE-PVFHLLTRILTVLGGVLGLCRLID 345 Trichomonas vaginalis G3
XP_001310077 282 SSYQNYRGSNSTK-------------YPGVFFSYDVSLIGIVSSQNS--SLMDLVTELMSILGGVFAIATFLD 339 Trichomonas vaginalis G3
EAX90096     163 TSYDRYRDESSDK-------------LPGVFINYDISPLILQYVLDR--PIYQIIIDMMAIIGGIFAFGLLID 220 Trichomonas vaginalis G3
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