6EX6,5MQO,5OPJ


Conserved Protein Domain Family
Glyco_hydro_127

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pfam07944: Glyco_hydro_127 
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Beta-L-arabinofuranosidase, GH127
One member of this family, from Bidobacterium longicum, UniProtKB:E8MGH8, has been characterized as an unusual beta-L-arabinofuranosidase enzyme, EC:3.2.1.185. It rleases l-arabinose from the l-arabinofuranose (Araf)-beta1,2-Araf disaccharide and also transglycosylates 1-alkanols with retention of the anomeric configuration. Terminal beta-l-arabinofuranosyl residues have been found in arabinogalactan proteins from a mumber of different plantt species. beta-l-Arabinofuranosyl linkages with 1-4 arabinofuranosides are also found in the sugar chains of extensin and solanaceous lectins, hydroxyproline (Hyp)2-rich glycoproteins that are widely observed in plant cell wall fractions. The critical residue for catalytic activity is Glu-338, in a ET/SCAS sequence context.
Statistics
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PSSM-Id: 400342
View PSSM: pfam07944
Aligned: 18 rows
Threshold Bit Score: 496.834
Threshold Setting Gi: 81443376
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EX6_B  14 SVKVTDNFwgQRLQASREVTI----PLAFSK--------CEETGRye------------nfVKAAH------PSDTYK-- 61  Bacteroides thetaiota...
Q8A5Y9  38 NVKVNDAFwsPKFKTWNEVTI-------NDV--------LNKFEGkh------------tnAPEQHn-----AFCNFDkv 85  Bacteroides thetaiota...
Q8G7S2  13 NVTVTDSFwrTEQELVRTAVIpyqwNALNDNvpgaapsyCMHNFKaaaaqnkrkdtqgnafVPPKY------TFRGFEal 86  Bifidobacterium longum
Q92TH5  17 DVELG-GFwgKWQDAVCRSTA----ETLLDR--------CVEAGMik------------aiDVSQPspgiviPIQPWG-- 69  Sinorhizobium meliloti
Q8G750   2 NVTITSPFwkRRRDQIVESVIpyqwGVMNDE--------IDTTVPddpagnql-adnkshaVANLKv-----AAGELDd- 66  Bifidobacterium longum
Q9WYB6  22 SVRVN-GFmgKYFETLVNVTL----PTQYDL--------LENTGR----------------LDNFRi-----AAGKMEgs 67  Thermotoga maritima
5MQO_A  43 AVHWTNGFwgERFNVFSGTSL----QSMWNT--------WNTPEVsh-------------gFRNFEi-----AAGVCKg- 91  Bacteroides thetaiota...
Q7US16  58 DVNWTDGFwaQRLETCREKTI----PAMWEI--------MRGTQYkp-------------yLEHFRi-----AAGLAEg- 106 Pirellula sp.
Q9KBP8   6 NVKLTKGLfyNSQKKGNDVIL----ALDIDR--------LLAPYYea------------anLPPKKr-----SYGGWE-- 54  Bacillus halodurans
Q8A3P3  50 EVRLLDSPflDLQRKGKEYLL----WLNPDS--------LLHFYRie------------agLPSKAa-----PYAGWEsq 100 Bacteroides thetaiota...
6EX6_B  62 -----------VEGFSFDDTDVYKTIEGASYSLQTYPDKKLQKYIDSVLVIVAGAQe--PDGYLYTARTMNpkhp----- 123 Bacteroides thetaiota...
Q8A5Y9  86 akge--rgtqgHFGEPWFDGLIYESIRGIADYLVMYPDKELETRIDRYIDRIEAAQmtePTGYLETYTLLK--------- 154 Bacteroides thetaiota...
Q8G7S2  87 pedpanpdpdkFYGFVFQDTDFSKWVEAVGYSLAHHPDPALEQTADQAVDIVCAAQl--DNGYLDAYYILN--------- 155 Bifidobacterium longum
Q92TH5  70 -----------GTTQMFWDSDLGKSIETIAYSLYRRPNPELEARADRIIDMYEKLQd--EDGYLNAWFQRV--------- 127 Sinorhizobium meliloti
Q8G750  67 ----------eFHGMVFQDSDVYKWLEEAAYALAYHPDPELKALCDRTVDLIARAQq--SDGYLDTPYQIK--------- 125 Bifidobacterium longum
Q9WYB6  68 ----------yKTLFPFDDTDVYKWAETVSFALANRKLPELEKILDSVIEEVKAAQd--EDGYLGTYLSGD--------- 126 Thermotoga maritima
5MQO_A  92 ----------eHWGPPFHDGDMYKWMEGVASVYAVNKDPELDKLMDNFIACVVKAQr--ADGYIHTPVVIEelnkgidsh 159 Bacteroides thetaiota...
Q7US16 107 ----------rYRGASFNDGDFYKWMEAVCLLQAVDKDHVWDQRLNEIIRVIGKAQr--SDGYLHTPVLIAn-------- 166 Pirellula sp.
Q9KBP8  55 -------------EREIRGHSLGHWLSAAAAMYETTGDKALLERIDRAVQELATIQd--DVGYVGGVKRAHfdemfsg-- 117 Bacillus halodurans
Q8A3P3 101 ---------dvWGAGPLRGGFLGFYLSSVSMMYQSTDDKRLLKRLKYVLKELELCQkagKDGFLLGLKDGRklfaevas- 170 Bacteroides thetaiota...
6EX6_B 124 ---------------hnwAGKERWVAve-----nlSHEFYNLGhmiegavAHYQATGKRNFLDIAIKYADCV----CREI 179 Bacteroides thetaiota...
Q8A5Y9 155 ------------------EPEHRWGDnggf--lrwQHDVYNAGmmieaavHYYKATGKTKLLEVATRYTNYM----ADYM 210 Bacteroides thetaiota...
Q8G7S2 156 ------------------GMDRAFTNlr------dHHELYCLGhlvegavAYYQGTGKDKLLKAACRFADYV----DERF 207 Bifidobacterium longum
Q92TH5 128 ------------------QPDRRWTNlr------dHHELYCAGhlieaavAYYQATGKRKLLDIMCRFADYM----ITVF 179 Sinorhizobium meliloti
Q8G750 126 --------------------SGVWADrprfsliqqSHEMYVMGhyieaavAYHQVTGNEQALEVAKKMADCL----DANF 181 Bifidobacterium longum
Q9WYB6 127 ------------------RKKERWTNla------wNHELYNAGhliqaavAHRRVTGKNTLFEVAKRFADHI----YNTF 178 Thermotoga maritima
5MQO_A 160 tladsqqqtvigtkvgseDEKGAFANr-------lNFETYNLGhlmmagiVHHRATGKTTLFDAAVKATDFLch-fYETA 231 Bacteroides thetaiota...
Q7US16 167 -----------------rNGDDSVQPigd----rfNFEMYNMGhlmtaacVHHQVTGKDSLLRIAQRAADFLdd-aYRNP 224 Pirellula sp.
Q9KBP8 118 -----------efqvghfNIAGTWVP------------WYNLHklfagliDVHQLTGHSLALTVVTKLADWAkk-gTDQL 173 Bacillus halodurans
Q8A3P3 171 ----------gkiktnnpTVNGAWAP------------VYLINkmllglsAAYTQCQMEEALPILIRLADWFgyqvLDKL 228 Bacteroides thetaiota...
6EX6_B 180 GNGPQQKKYVPGHQIAEMALVKLY--------------MATGDKKYLDQAKFFLDTRGyts------------------- 226 Bacteroides thetaiota...
Q8A5Y9 211 GPAP-KKNIVPSHSGPEEAIIKLYwlfkeqpelkkqlsVSVNEDAYWKLATFWIENRGhhcgyplwltwgngksekwird 289 Bacteroides thetaiota...
Q8G7S2 208 GRKPGQLRGYPGHEIAEMALVRLY--------------EVTGEQRYLDLAEYFVTERGrqpyifdiqadenak------- 266 Bifidobacterium longum
Q92TH5 180 GRGEGQIPGYCGHEEIELALVKLA--------------RVTGEKKYLDLSKFFIDERGtephffneearr---------- 235 Sinorhizobium meliloti
Q8G750 182 GPEEGKIHGADGHPEIELALAKLY--------------EETGEKRYLTLSQYLIDVRGqdpqfyakqlkam--------- 238 Bifidobacterium longum
Q9WYB6 179 GPE--KKEGAPGHPEVEMALVELY--------------RETGDRKYLDLARYFIYARGkglasv---------------- 226 Thermotoga maritima
5MQO_A 232 SAELARNAICPSHY---MGVVEMY--------------RATGNPRYLELSKNLIDIRGmve------------------- 275 Bacteroides thetaiota...
Q7US16 225 TPEQAGHAICPSHY---MGLLDLY--------------RTTGETRYLDLAKRLVKMRDltv------------------- 268 Pirellula sp.
Q9KBP8 174 TDDQFQRMLICEHGGMNEAMADLY--------------TLTGHKDYLQLAIRFCHWAVle-------------------- 219 Bacillus halodurans
Q8A3P3 229 TDDQIQRLLICEHGSINESYVEAY--------------ELTGEKRFLDWARRLNDHAMwg-------------------- 274 Bacteroides thetaiota...
6EX6_B 227 --------------rkDTYSQAHKPVVEqDEAVGHAVRavymysGMADVAAITGDSSYIKAIDKIWDNIVSKKIYITGGI 292 Bacteroides thetaiota...
Q8A5Y9 290 aqynapehgehsrptwGDYAQDSIPVFEqQTIEGHAVRatllatGITTAALENHSPKYIETAKRLWDNMTGRRMFITGGV 369 Bacteroides thetaiota...
Q8G7S2 267 -rdadanykpntdpnrYAYHQANKPVTEqDEAVGHAVRagyfysGLADVARLADDQDLADAAERLWRNIVDKKLYVTGGI 345 Bifidobacterium longum
Q92TH5 236 ----dgrdpesfiqktYEYGQAHQPVREqTKVVGHAVRamylysGMADIATEYRDDSLTAALETLWDDLTTKQMYITGGI 311 Sinorhizobium meliloti
Q8G750 239 ---ngdnifhdlgfykPTYFQAAEPVRDqQTADGHAVRvgylctGVAHVGRLLGDQGLIDTAKRFWKNIVTRRMYVTGAI 315 Bifidobacterium longum
Q9WYB6 227 -----------prnpgPEYFIDHKPFVElEEITGHAVRalylcsGATDLYLETGDEKIWQALNRLWENFVTKKMYITGGA 295 Thermotoga maritima
5MQO_A 276 --------------sgTDDNQDRIPFRDqYRAMGHAVRanylyaGVADVYAETGEQQLMKNLTSIWNDIVTRKMYVTGAC 341 Bacteroides thetaiota...
Q7US16 269 --------------dgGDDNQDRMPFTQqTEAVGHAVRatylyaGIADLYAEIGDDALWSSLEKIWQNVVHQKMYITGGC 334 Pirellula sp.
Q9KBP8 220 ---------------pLANGIDELEGKHaNTQIPKVI-------GAAKLFEITGDDTYRAIAEFFWRQVTNDRSYIIGGN 277 Bacillus halodurans
Q8A3P3 275 ---------------pLSEGKDILFGWHaNTQIPKFT-------GFHKYYQFTGDERFLTAATNFWNIVTQNHTWVIGGN 332 Bacteroides thetaiota...
6EX6_B 293 GAHHa-----------------gEAFGNNYELPNLSa---yCETCAAIGNVYMNYRLFLLHGDAKYFDVLERTLYNGLIS 352 Bacteroides thetaiota...
Q8A5Y9 370 GAIHe-----------------dEKFGPDFFLP-PGa---yLETCAAIGAGFFSQRMNELTGKGMYMDELERVLYNSLLT 428 Bacteroides thetaiota...
Q8G7S2 346 GGTVd-----------------gEAFSYNYDLPNDSa---ySETCAAISLAFFARRMLELAPKAEYADVMESALYNTTLA 405 Bifidobacterium longum
Q92TH5 312 GPAAs-----------------nEGFTCYYDLPNDTa---yAETCASVGLVFWASRMLGRGPDRRYADIMEQALYNGALP 371 Sinorhizobium meliloti
Q8G750 316 GSTHv-----------------gESFTYDYDLPNDTm---yGETCASVAMSMFAQQMLDLEPKGEYADVLEKELFNGSIA 375 Bifidobacterium longum
Q9WYB6 296 GSRHd-----------------wESFGEEYELPNRRs---yAESCASIANFMWNFRMLLATGDGKFADVMEQVLYNGLLS 355 Thermotoga maritima
5MQO_A 342 GALYdgtspdgtcyepdsiqkvhQSYGRPYQLPNSTa---hNETCANIGNMLFNWRMLEVTGDAKYAELVETCLYNSVLS 418 Bacteroides thetaiota...
Q7US16 335 GALHdgaspdgsk-nqreitrvhQAFGRNYQLPNTTa---hNETCANIGNVLWNWRMFLANGESKHIDVLELALYNSILS 410 Pirellula sp.
Q9KBP8 278 SNS--------------------EHFGPANKETLGVe---tAETCNTYNMLKLTEHLFRWNRSSQLMDYYEKALYNHILA 334 Bacillus halodurans
Q8A3P3 333 STG--------------------EHFFPKEEFADRVllvggPETCNSVNMLRLTESLFCQYPDAAKASYYERVLFNHILS 392 Bacteroides thetaiota...
6EX6_B 353 GVSLDGGSFFYPNPL---SSNGKYSRK------------PWfGCACCPSNVSRFIPSLPGYVYAVK------ND--QVYV 409 Bacteroides thetaiota...
Q8A5Y9 429 AVSLKGDNYTYQNPL----NAEKHNRW------------EWhGCPCCPPMFLKITSALPGFIYASD------KK--GVYI 484 Bacteroides thetaiota...
Q8G7S2 406 GMALDGKSFFYVNPL---EVNPYACHKdsrlrhvkpvrqKWfGCACCPPNIARIVESVQEYAYTVA------EDggTLFT 476 Bifidobacterium longum
Q92TH5 372 GLSIDGRTFFYDNPL---ESTGRHHRW------------KWhHCPCCPPNIARLVTSIGSYMYAVA------ED--EIAV 428 Sinorhizobium meliloti
Q8G750 376 GISLDGKQYYYVNAL---ETTPDGLDNpdrhhv-lshrvDWfGCACCPANIARLIASVDRYIYTER------DGgkTVLS 445 Bifidobacterium longum
Q9WYB6 356 GISLDGKHYFYFNPL---EDYGRTRRQ------------KWfDCACCPPNLARFIVSFPGYMYTTS------DD--GVQV 412 Thermotoga maritima
5MQO_A 419 GISLDGKKYFYTNPLrisADLPYTLRWpke-------rtEYiSCFCCPPNTLRTLCQAQNYAYTLS------PE--GIYC 483 Bacteroides thetaiota...
Q7US16 411 GVDLDGTNFFYTNPLrqsDTAPVALRWagg-------rkPFvTSFCCPPNLARTIAGVGLYAYGKS------DD--TVWV 475 Pirellula sp.
Q9KBP8 335 SQDPDSGMKTYFVSL---QPGHFKvy-----------ssLEeSFWCCFGTGLENPARYTRTIYDRD------DR--HIYV 392 Bacillus halodurans
Q8A3P3 393 AYDPEKGMCCYFTSM---RPGHYRiy-----------asRDsSFWCCGHTGLESPAKLSKFIYSHSkriidgDP--DIRV 456 Bacteroides thetaiota...
6EX6_B 410 NLYLSNKAELKVDKk-kILLEQETGYPWNGDIRLKI----------TQGNQDFTMKLRIPGWvrgnvlpgdlysyadnqK 478 Bacteroides thetaiota...
Q8A5Y9 485 NLFIGSETEIKLSSknsVQLKQETSYPWKGKVNISVn---------PQKTDKFPIKVRIPGWaqgienpy--elyqsnlK 553 Bacteroides thetaiota...
Q8G7S2 477 HLYMGGVAKAELNGt-aVELDVTANLPWQGDGKAVVrlggdaagtsAQAPARFTLAFRLPGWvgd------------esA 543 Bifidobacterium longum
Q92TH5 429 HLYGESTARLKLASgaeVELRQETNYPWEGAIAFATk---------LDRPAKFALSLRIPEW-----------------A 482 Sinorhizobium meliloti
Q8G750 446 HQFIANKADFASG----LTVEQRSDFPWDSHVEYTVsl------paSAADSSVRFGLRIPGWs----------------L 499 Bifidobacterium longum
Q9WYB6 413 HLYEKSTARLDFKGs-vVEIEQETDYPWSGEVAFTIk---------TDIEEPFSIYLRLPSW-----------------A 465 Thermotoga maritima
5MQO_A 484 NLYGANTLTTNWKDkgeLALVQETDYPWEGNVRVTLnk-------vPRKAGAFSLFFRIPEW-----------------C 539 Bacteroides thetaiota...
Q7US16 476 NLYGSNTLDTHLTNsghVRIEQATDYPWDGHIQITIa---------ECQNQPVCLKLRIPGW-----------------A 529 Pirellula sp.
Q9KBP8 393 NLFMASEIHLKDLQ---VQIRQETNFPETDRTKLTFv---------KADGVSIKLHIRVPEWv----------------A 444 Bacillus halodurans
Q8A3P3 457 NLFIPSILFWKEKG---IELIQQNRLPESEQVSFMLn---------LKKKQELILRIRKPDW-----------------A 507 Bacteroides thetaiota...
6EX6_B 479 PAYQVSVNGQT--------VESDVNDGYLSIARKWKKGDVVEVHFDMIPRIVKAnpkvEADHGRVAVERGPIVYC 545 Bacteroides thetaiotaomicr...
Q8A5Y9 554 GAPQLFVNGKS--------VPIKIVDGYAEINRKWQKGDLIELELPIQPRIITAhtntKDLSNTVCIASGPIIYC 620 Bacteroides thetaiotaomicron
Q8G7S2 544 AAAAITATGESesgadssrVTREIRDGYLYLTGEWRDGDTVTFDFPMPVRMLAAnplvREDAGKVAFVRGPITFC 618 Bifidobacterium longum
Q92TH5 483 AGATLSVNGTMl------dLSAHLTGGYARIEREWSDGDRVALYLPLAIRPQYAnpkvRQDVGRVALMRGPLVYC 551 Sinorhizobium meliloti
Q8G750 500 GSYTLTVNGKP--------AVGSLEDGFVYLVVNAGDTLEIALELDMSVKFVRAnsrvRSDAGQVAVMRGPLVYC 566 Bifidobacterium longum
Q9WYB6 466 DDFVLRVDGKA--------VIAKPQNGYVKLSQSWKGKHTVELSLPMKAVFIEAhpfvRDDLGKAAVKRGPVVYC 532 Thermotoga maritima
5MQO_A 540 GKAALTVNGQPv-------SMNAKANTYAEVNRTWKKGDVVELVMDMPVCLLEAhplaEEIRNQVVVKRGPLVYC 607 Bacteroides thetaiotaomicron
Q7US16 530 TKTTLKIDGVPt-------KTTIKSESYVSLKRVWSPGTVIELDFAMPARLIEShplvEETRNHVAVKRGPIVYC 597 Pirellula sp.
Q9KBP8 445 GPVTARINGKE--------TFSESGADYLTIEREWQKGDEIEVHLPMELRIYEA----KDDSHKVGIMYGPIVLA 507 Bacillus halodurans
Q8A3P3 508 DKVTFIINGKVe-------YPILDKDGYWVVNRTWARKNKIILQLPMHVYVESL----MGSDRYAALLYGPYVLA 571 Bacteroides thetaiotaomicron
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