1KN7


Conserved Protein Domain Family
K_channel_TID

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pfam07941: K_channel_TID 
Potassium channel Kv1.4 tandem inactivation domain
This family features the tandem inactivation domain found at the N-terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N-terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to being about fast inactivation of the Kv1.4 channel, which is important for the channel's role in short-term plasticity.
Statistics
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PSSM-Id: 400339
View PSSM: pfam07941
Aligned: 6 rows
Threshold Bit Score: 57.3113
Threshold Setting Gi: 30749374
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1KN7_A         4 MEVAMVSAESSGCNSHMPYGYaAQARARERER-----LAHSRAAAAAAVAAAT-AAVE----GTGGSGGGP--------- 64 
2_pfamImport   1 MEVAMVSADSSGCNTHLPYGYaAQARARERER-----LAQSRAAAAAAVGGGG-GGGG----GGGGGGGGD--------- 61 
Q61423         1 MEVAMVSAESSGCNSHMPYGYaAQARARERER-----LAHSRAAAAAAVAAAT-AAVE----GTGGSGGGP--------- 61  house mouse
XP_013978302   1 MEVAMVSAESSGCNSHMPYGYaAQARARERER-----LAQSRAAAAAAVAAATaAAAE----GVGGPGGGA--------- 62  dog
XP_022522782   1 MEFAMVGADSGGCNPHMPYGY-AQARARERERe---rERHSRAAAAAAAAAAAaAAADsgatGEGGGTGGT--------- 67  Mexican tetra
XP_005455796   1 MEFAMVGAD-GGCNSHLPYGY-AQARARERERererqVAHTRAAAAAAAAEGG-TCTE----GGGGGGGGScggvggsts 73  Nile tilapia
1KN7_A        65 ----------HHHH--QTRGAY 74 
2_pfamImport  62 ----------HHYHqeQSRGAS 73 
Q61423        62 ----------HHHH--QTRGAY 71  house mouse
XP_013978302  63 ----------HQQH--QQHQQH 72  dog
XP_022522782  68 ----------CIHG--QQHQVR 77  Mexican tetra
XP_005455796  74 ntsssahllnNRQH--QSRAAs 93  Nile tilapia
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