2BDS,1WXN,1WQK


Conserved Protein Domain Family
Defensin_4
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pfam07936: Defensin_4 
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Potassium-channel blocking toxin
This family features the antihypertensive and antiviral proteins BDS-I and BDS-II expressed by Anemonia sulcata. BDS-I is organized into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus. Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism.
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Statistics
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PSSM-Id: 254527
Aligned: 10 rows
Threshold Bit Score: 30.8588
Created: 22-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BDS_A  2 APCFCSGKPgrGDLWILr-GTCPGGYgYTSNCYKWPN 37  snake-locks sea anemone
P86463  2 VPCSCRGKS--GTYWSA--GKCPGEH-YTTYCNNLIG 33  Bunodosoma cangicum
P69930 35 LSCRCEGKTeyGDKWLFh-GGCPNNYgYNYKCFMKPG 70  Antheopsis maculata
P59084  2 APCFCPGKPdrGDLWILr-GTCPGGYgYTSNCYKWPN 37  snake-locks sea anemone
P84919  2 LPCDCHGHT--GTYWLNyySKCPKGYgYTGRCRYLVG 36  Bunodosoma caissarum
P86464  2 VSCKCGSKK--GVYWFGqiTGCPGGHgYKGSCSYVLG 36  Bunodosoma cangicum
P86462  2 VPCKCGSKK--GVYWFGqiTGCPGGHgYKGSCNYLLG 36  Bunodosoma cangicum
1WXN_A  2 TACSCGNSK--GIYWFYr-PSCPTDRgYTGSCRYFLG 35  clonal anemone
P86461  2 TTCYCGSTL--GIYWFAv-SSCPSGRgYTGHCGYFLG 35  Bunodosoma cangicum
1WQK_A  2 TTCYCGKTI--GIYWFGt-KTCPSNRgYTGSCGYFLG 35  clonal anemone
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