1GRR


Conserved Protein Domain Family
CPT

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pfam07931: CPT 
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Chloramphenicol phosphotransferase-like protein
The members of this family are all similar to chloramphenicol 3-O phosphotransferase (CPT) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group to the C-3 hydroxyl group of Cm, CPT inactivates this potentially lethal metabolite.
Statistics
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PSSM-Id: 400334
View PSSM: pfam07931
Aligned: 6 rows
Threshold Bit Score: 223.098
Threshold Setting Gi: 81721447
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GRR_A   3 TRMIILNGGSSAGKSGIVRCLQSVLPEPWLAFGVDSLIEa-MPLKMQS---------------AEGGIefdadggvsiGP 66  Streptomyces venezuelae
Q82PT5  24 GMVILLNGTSSSGKTSMARALLDILDGTWFHMPVDAFHA--MRCKRDI---------------SDEEL----------QP 76  Streptomyces avermitilis
Q92P10   8 GRIVILNGAPRSGKSSIAEAIQETFDGPWMNLGVDAYMEr-VMPRRCL---------------PGIGLrpgge-lpeiEA 70  Sinorhizobium meliloti
Q82PM5   2 ADVIVLNGGSSSGKSGIVRCLQAVLPDPWLALGTDTLVDa-MPASMQA---------------SDAGIefapdgevivGP 65  Streptomyces avermitilis
Q6LNH4   2 ANIIFLHGTSSSGKSTLSQVIQKQSETPFWHFASDQFVEagMLPKRVN---------------DGGDFdw--------sK 58  Photobacterium profundum
P9WL55  23 GKLILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFWFa-LPPEQLDlarvrpeyytwdsavEADGLewft---vhpGP 98  Mycobacterium tubercu...
1GRR_A  67 EFRALEGAWAEGVVAMARAGARIIIDd----VFLGGAA-AQERWrSFVGDLDVLWVGVRCDGA-VAEGRETARGD----- 135 Streptomyces venezuelae
Q82PT5  77 EIDRTAKGFHRAVAGMAAGGNNLVVD-----YPLSRRWrLLDLL-DLLVPEDTVLVGVRCPLP-ELERRESERGD----- 144 Streptomyces avermitilis
Q92P10  71 LVPLFYAALYESVAAHSRLGLNVVADvghhdAYGEPRHiLPDCArRLL-GLPVLFVGVRCPVEtIMERRNRGQPG----- 144 Sinorhizobium meliloti
Q82PM5  66 EFRTLEAAWIEGVAAMARAGARVIVDe----VFLGGAD-SQQRWqKALRDLRVLWVGVRCDGA-VAAGREIARGD----- 134 Streptomyces avermitilis
Q6LNH4  59 NRPLFFDAFHGCIKAVADAGNNIILDh----IIESKEW--FHYLqELLSNHDVFFVGIHCPIE-VLREREINRGDgsign 131 Photobacterium profundum
P9WL55  99 ILDLAMHSRYRAIRAYLDNGMNVIADd----VIWTREW-LVDAL-RVFEGCRVWMVGVHVSDE-EGARRELERGD----- 166 Mycobacterium tubercu...
1GRR_A 136 RVAG-------------MAAKQAYVVHEGVEYDVEVDTTHKESIECAWAIAAHVV 177 Streptomyces venezuelae
Q82PT5 145 RQPG-------------LAAMQYGAVHSHELHDLDIDSSLHTPAECALRIRDFLP 186 Streptomyces avermitilis
Q92P10 145 REGGyltgseaepvprqVLAWQRE-VHRPGIYDLAVDTSMMTPDECAALIRKRLE 198 Sinorhizobium meliloti
Q82PM5 135 RVIG-------------MAASQADVVHRGVVYDLEVDTTHAESMECARAIATHVR 176 Streptomyces avermitilis
Q6LNH4 132 RYLG-------------ESEYHLKHVHTYSAYDYEIDTSSQPTEHSAEMVLSAWE 173 Photobacterium profundum
P9WL55 167 RHPG-------------WNRGSARAAHADAEYDFELDTTATPVHELARELHESYQ 208 Mycobacterium tuberculosis H37Rv
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