Conserved Protein Domain Family
DUF1646

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pfam07854: DUF1646 
Protein of unknown function (DUF1646)
Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei (Swiss:Q8PXG5, Swiss:Q8PXG7 and Swiss:Q8PXG8).
Statistics
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PSSM-Id: 285138
Aligned: 5 rows
Threshold Bit Score: 360.215
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O29471  14 AAGLFIILFLVLILPFRVRKIEENLEPFFLIM---GIVAVTVSGLws-----leLIIEALETPVRITE--VMGIPVGIFQ 83  Archaeoglobus fulgidus
Q9YFW4  15 TAVLSAILILVLVLPFKVRIVEENLEAFFFIMgllGVATIYYYGIlptpdsligLFIKAFKTPLAIAH--VGPIPIGIVQ 92  Aeropyrum pernix
Q8ZUI4   6 LYLQIVFLVLLIALPILSKKVEHNLELFFLAM---AVAGATLEGLws-----whLLKEALLHPVAVYQpgIGYIPIGITQ 77  Pyrobaculum aerophilum
Q8RCZ3  45 IAALLVILLMILILPLVNRYIEHNIEYFLFSM---GVAAAFVSGVfs-----ydLIIHIFKNHLLYL----------VTV 106 Caldanaerobacter subt...
Q8R782   2 VTALVVILVLILLLPFVVKQVEHNLEYFLFTM---GIISVIVSKQfs-----veLFFHIFKNPLIYY----------ITL 63  Caldanaerobacter subt...
O29471  84 VVLIVGLIIHYYNKQVYSFLVAVLKKLGIKVFAFLVVTVFGLASSIISVIVSAVILAEIALVMPLERKSKVEFVVIACFA 163 Archaeoglobus fulgidus
Q9YFW4  93 AVVFFGLVFYFFHKHIYSILASTMEKVGIPVFAFILTFLLGLISSVISVIVTAVILAEIAAALNISRERKVKYVVYASFA 172 Aeropyrum pernix
Q8ZUI4  78 VVLAAGLVFYALRHK----MAEKADALARPAVIAGLIFGLGLSSSVISAVVAAAIMAELLGFANAPHAYKARAAVYGAFA 153 Pyrobaculum aerophilum
Q8RCZ3 107 AVFLSGLLFEIFKDKFKTLIEITIARIPLKVFVFLVIVILGLTASIITAIIASIILVEIIHLLPLKHKDKVVITVIASLS 186 Caldanaerobacter subt...
Q8R782  64 AVLIAGLIFALLKEKLKIGVEKVADKISLRLFAFIIIVILGLMSSIITAIIASLVLVEVVNYLPLTRKNKINLIVIACFS 143 Caldanaerobacter subt...
O29471 164 VGFGAALTPVGEPLSTIVVKKLNEDFFYLIELVGEYIIPSVIILGIYAAMRVGGVSVKE--IEI--PeYTETLRT----- 234 Archaeoglobus fulgidus
Q9YFW4 173 VGIGAALTPLGEPLSTIAISKLNAHFTYLIDILGVYIVPGIAVSAVAAAYSLRGEVYREglVKF--V-YEESINE----- 244 Aeropyrum pernix
Q8ZUI4 154 IGAGAALLPIGEPLSTIAVAKLKQGFFFLVDVLFDAVFIIVAFFALYAYFSLKRL--RQpgVEV--VpYEPELKE----- 224 Pyrobaculum aerophilum
Q8RCZ3 187 IGMGAALTPIGEPLATIATSKLNESFLYLFTTLGIYIIPAVLALGFLGLLYINKLEKNSliIEEnyVeEAEEIKKierfq 266 Caldanaerobacter subt...
Q8R782 144 IGLGAALTPVGEPLATIVVSKLHADFFYLARLIGIEIIIAILALGLIGTFFAKRESGIGepTED--VeADENIRE----- 216 Caldanaerobacter subt...
O29471 235 -VVIRAVRVYVFIAALVLLGEGFTPIIYWYISKIPPEIIYWVNMVSAILDNATLAAAEIGPQLTELQIKGALMGLIISGG 313 Archaeoglobus fulgidus
Q9YFW4 245 -ILLRGFRVFLFVAALELLGASFTPMVKWYFAQLPSWALYWINTISAVVDNATLTAAEMGPFLTEEQIRSALMSLLISGG 323 Aeropyrum pernix
Q8ZUI4 225 -VITRAVKIFIFIFALTILGEFFKPLAVA-VAELGREYLYVFGLLSAVADNATLVAALVTPEMAVETLRSFIISLVIAGG 302 Pyrobaculum aerophilum
Q8RCZ3 267 fIFIQAFKIFVFILALELLGAGFKPVIDNYIIHLDSRLLYWINVTSAVLDNATLAAAEISPHMTTEQIRAILMGLLISGG 346 Caldanaerobacter subt...
Q8R782 217 -VFIRAFKVFVFIFALELLGTGFKPIIDLYIVKMKSEILYWVNTISAIVDNATLAAAEISPSMTPEQIRAILMGMLISGG 295 Caldanaerobacter subt...
O29471 314 MLIPGNIPNIVVAGRLRITMGEWARIGVPLGLIMMTIFFVIIYVL 358 Archaeoglobus fulgidus
Q9YFW4 324 MLIPGNIPNIVAAGRLRITMNEWARVGVPFGIALLLAYFIVIEVL 368 Aeropyrum pernix
Q8ZUI4 303 LTIPGNVPNIVMAGVLKIGFKEWIKLALPVGIAVFIAIGIYVLWL 347 Pyrobaculum aerophilum
Q8RCZ3 347 MLIPGNIPNIISAGKLNIKSREWALVGIPLSLIGLIIYFIVLFVI 391 Caldanaerobacter subterraneus subsp. tengcongensis
Q8R782 296 MLIPGNIPNIISAGKLKIKSTEWARIAVPLGAILLIVYYIVLFVI 340 Caldanaerobacter subterraneus subsp. tengcongensis
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