Conserved Protein Domain Family
GCFC

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pfam07842: GCFC 
GC-rich sequence DNA-binding factor-like protein
Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homolog. This is thought to be a protein involved in transcriptional regulation due to partial homologies to a transcription repressor and histone-interacting protein. This family also contains tuftelin interacting protein 11 which has been identified as both a nuclear and cytoplasmic protein, and has been implicated in the secretory pathway. Sip1, a septin interacting protein is also a member of this family.
Statistics
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PSSM-Id: 400273
View PSSM: pfam07842
Aligned: 32 rows
Threshold Bit Score: 112.547
Threshold Setting Gi: 74852755
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001592803 449 WDPVIEALKTVDGLDISGA-NEELSNIAVAAVHPFLRQASEGWQPLEDPKlnGMVPNLYKIRHILGavtndkviisqdSF 527  Sclerotinia sc...
Q54JF1       631 INYIADKFKHWKSKDLKSYqKAQMPFIMPSILAPFIRLQMIDWSPLDDIY------------------------------ 680  Dictyostelium ...
Q84T85       651 LRIVKDKFEGWKTQYPLAYrDAHVALSAPSVFTPYVRLELLKWDPLHETT------------------------------ 700  Japanese rice
Q9FNN3       598 LSKVKARFERWKRDYSSTYrDAYMSLTVPSIFSPYVRLELLKWDPLHQDV------------------------------ 647  thale cress
Q9FY92       303 LSRVKSIFKRGARHPSPAFrAAYTSLTVPSMYSPYLRLELLRWDPLHQDV------------------------------ 352  thale cress
Q9Y5B6       595 IDCIKSQFEAWRSKYYTSYkDAYIGLCLPKLFNPLIRLQLLTWTPLEAKC------------------------------ 644  human
Q4SFV4       622 LDYIKCHFEVWRRDYAECYrEAYIGLCLPKLFNPLVRLQLITWNPLEGEC------------------------------ 671  spotted green ...
Q7PYN8       655 VGGILERFEQWREHDLPAYsDAYVSLCLPKILGPLIRLEHVCWNPLTMDA------------------------------ 704  Anopheles gamb...
Q5B1K2       312 LDYVTDQLESLEIQYRAEIdEYRLWETAVAAIHPLFREAMEDWEPLKAPT--FLVANLRRLQPILS------------RK 377  Aspergillus ni...
Q0CQW3       291 VDEVTDKLESMEIKYHNDIdEYRLSETAVAALHPLFRQAMEEWEPLKEPT--FLVSNLRRLQPLLS-------------R 355  Aspergillus te...
XP_001592803 528 MNALHKNRVKSTTPYESMIYKIIFPKIVsSINKNWDVYNPAPVLAFLDAWQGLLPKFVRSQILDQAIVGKLNDAVSS-WN 606  Sclerotinia sc...
Q54JF1       681 --------------FDTMSWYNQLFSYG-GG-------GGDDDDILIP------------KLVEKIIIPKVETFITYiWN 726  Dictyostelium ...
Q84T85       701 -------------DFFGMEWHKILFDYGeQNSESGTD-PNNVDKDLIP------------VLVEKVALPILHHRIMHcWD 754  Japanese rice
Q9FNN3       648 -------------DFFDMKWHGLLFDYGkPEDGDDFA-PDDTDANLVP------------ELVEKVAIPILHHQIVRcWD 701  thale cress
Q9FY92       353 -------------DFSDMNWHGLLFHSRiVCGST----PVCTNPNFVS------------ELVKYVAVPILHHRIVRcWD 403  thale cress
Q9Y5B6       645 ------------RDFENMLWFESLLFYGcEEREQE---KDDVDVALLP------------TIVEKVILPKLTVIAENmWD 697  human
Q4SFV4       672 ------------DNFEYMLWFESLLFYGfDEHAALQ--KGDGDNGLLP------------SIVEKVILSKLAALAEQvWD 725  spotted green ...
Q7PYN8       705 -----------LVELENEKWYRTAAQYGcSA-TTEAALAADPDVRLIP------------TLVEKIFLPKLTALVEQyWD 760  Anopheles gamb...
Q5B1K2       378 ASEGQLVQRSSTSPYETMIYTLWLPRVRsALLNEWDVFNPSPATTLIVSWKELLPPFVYANVLDQLVVPKLTSGLNS-WK 456  Aspergillus ni...
Q0CQW3       356 KKKDDYAPRQSTSPYETMIYSLWLPRVRsALLNDWDMFDPSPATSLIVAWKDIIPQFVYTNVLDQLVVPKLTEGIKQ-WK 434  Aspergillus te...
XP_001592803 607 P--KKRrnhelPH-L-----WLFPWLQYLPaYHADPkss---------------tgLVSDVKRKFRHLIDSWDFHRGVIP 663  Sclerotinia sc...
Q54JF1       727 PlsKSQttnlkNT-Id----EILIYINDENhQNNNNnnnnnnnnnnnnnnnnnnnnVNQEVKFLFSQILST--------- 792  Dictyostelium ...
Q84T85       755 IlsTQRtknavDA-In----MVISYLPTSSkALHQ---------------------LLAAVNSRLTEAIAD--------- 799  Japanese rice
Q9FNN3       702 IlsTREtrnavAA-Ts----LVTNYVSASSeALAE---------------------LFAAIRARLVEAIAA--------- 746  thale cress
Q9FY92       404 IlsTREtrnvvAA-Ts----LVARYVFPSSeALAE---------------------LSLAIHARLVEAIIA--------- 448  thale cress
Q9Y5B6       698 PfsTTQtsrmvGI-Tl----KLINGYPSVVnAENKNtq-----------------vYLKALLLRMRRTLDD--------- 746  human
Q4SFV4       726 PlsRSQtarlvEF-Lh----RLRKGYPTVLhGDNKY-------------------------------------------- 756  spotted green ...
Q7PYN8       761 PlsTTQtfrlvRL-Lk----RFVRDYPSLR-SGCRPlr-----------------vLFQAILDKLKQSIDN--------- 808  Anopheles gamb...
Q5B1K2       457 PkrSSSsshsqQN-Srv-pwWLFTWLQYLDeRHTNPkqa---------------tgLLSDAKRKFRRVLDTWDLSAGPVP 519  Aspergillus ni...
Q0CQW3       435 PrsSSRrhassQQnSsrfpwWLFTWLQYLDeRHTNPkqp---------------tgLMSDAKRKFRVVLDNWDLDRGLIS 499  Aspergillus te...
XP_001592803 664 GLKQWREVLHPspnnDTWTPLIMNHVLPSMAKFLKnekNFLVDPND--QApyMSSLQGIFAWKDVLKPRVVGQV--LIGT 739  Sclerotinia sc...
Q54JF1       793 --------LNY----SISNGNLL---IPYSNRDLT----FSIKMYM--YS--LTMLDSIKIWSSNYQYIQLDSLmnLSDD 849  Dictyostelium ...
Q84T85       800 -------ISVP-----AWGSMVT-RTVPGASQYAA---------HRfgVA--IRLLKNVCLWKDIFAKPVLEKL--ALEE 853  Japanese rice
Q9FNN3       747 -------ISVP-----TWDPLVL-KAVPNTPQVAA---------YRfgTS--VRLMRNICMWKDILALPVLENL--ALSD 800  thale cress
Q9FY92       449 -------ISVP-----TWDPQVS-KDVPNAPQVAA---------YRfgTS--VRLMRNICMWKDVMELPVLEKL--ALSD 502  thale cress
Q9Y5B6       747 ------DVFMP-----LYPKNVLENKNSGPYLFFQ---------RQfwSS--VKLLGNFLQWYGIFSNKTLQEL--SIDG 802  human
Q4SFV4       757 ----------------------------------------------------TQLLGNILMWEGILSISCLKDL--ALDS 782  spotted green ...
Q7PYN8       809 ------DVFIP-----IFPKQAQ----EARSSFFQ---------RQfcSG--LKLLRNITSWQGILADAALKDL--AIGS 860  Anopheles gamb...
Q5B1K2       520 GFDLWHDALSS-----EFDTCLRNHLLPRLAAHLRa--DFDVNPQD--QD--LTAFENILKWKDWFQPNVLGLL--FVAE 586  Aspergillus ni...
Q0CQW3       500 GIELWRDALGS-----EFDVCLRNHLLPRLGRHLRe--DFEVNPQD--QD--LSALEDVLKWKDFFKPNVMGLL--LVAE 566  Aspergillus te...
XP_001592803 740 VFPMWHNVL 748  Sclerotinia sclerotiorum 1980 UF-70
Q54JF1       850 IID---FQI 855  Dictyostelium discoideum AX4
Q84T85       854 LLK---GKI 859  Japanese rice
Q9FNN3       801 LLF---GKV 806  thale cress
Q9FY92       503 LLF---GKV 508  thale cress
Q9Y5B6       803 LLN---RYI 808  human
Q4SFV4       783 TLN---RYI 788  spotted green pufferfish
Q7PYN8       861 LLN---RYL 866  Anopheles gambiae str. PEST
Q5B1K2       587 FFPKFHQIL 595  Aspergillus nidulans
Q0CQW3       567 FFPKWHNIL 575  Aspergillus terreus NIH2624
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