Conserved Protein Domain Family
PaRep2b
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pfam07775: PaRep2b 
PaRep2b protein
This is a family of proteins, expressed in the crenarchaeon Pyrobaculum aerophilum, whose members are variable in length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer functional.
Links
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Statistics
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PSSM-Id: 285070
Aligned: 13 rows
Threshold Bit Score: 474.365
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8ZXL7  468 LEAITPMLPLLYQLRDAIAKFADAFRVVTHEAIKRKFGIEWAYDVRNERFFKKLEEVVTMAEDYVYRNIAVERGPLDTSG 547  Pyrobaculum aerophilum
Q8ZY42    2 LEAVTPVLPTLHKLRDALAEFADAFRVVTREVIRAKFGVDWAYNIRNEMFFKKLNQIIAMAEDYVYRNVAVERGPLEIGW 81   Pyrobaculum aerophilum
Q8ZWR5  447 LEAVTPALPALHELRDALTEFADAFKVVTREAVKRKFGIDWGYDVRNEMFFKKLEEVVTMAEDYVYKNIAVEKGPLDTSG 526  Pyrobaculum aerophilum
Q8ZYB9 2414 VYVRGREIRLYFDAEYATGVFATAWTELS-----RLWRFGMEHGLYADHIFNKLDNIRRYVEEYANK-LRIEYELYSPQG 2487 Pyrobaculum aerophilum
Q8ZWY1  715 VYVRKGEARIYFNTEHATKMFATAWGNLC-----ALWRFSRESGLYADHVFKKLEGIRKYVESYVDK-VRIEHILRGDK- 787  Pyrobaculum aerophilum
Q8ZSX1  188 IFVGEYETILYFDRKYVAKMFSLVWGDLT-----TLWRLGRTLVSRADHIFKKLENIRMYVEEFANR-LKIVCILKSFSN 261  Pyrobaculum aerophilum
Q8ZVI5    2 LKAVMPALSTLYELGDTLTEFADSFKVVTREAIKKKHGVDWAYDVRNERFFKKLNEIITMADDYVYKNVTVERGPLDASG 81   Pyrobaculum aerophilum
Q8ZVL1    2 LKALVPELPTLHKLRDALAEFADSFSVVTNEVVKREFGIDLAYDVRNKSF-SKIEEAVTMTEDYVYKNIAVRRGPLDTSG 80   Pyrobaculum aerophilum
Q8ZWN2  108 LKALVPALPRLYEPRDALSEFADAFRAISGEVVRAKYGVDWAYDVREESFFKKFNEIITMVENYLRRNIVVERDPLDTSR 187  Pyrobaculum aerophilum
Q8ZVU0  468 LEAVTPALPALHELRDALTEFADAFKVVTREAVKRKFGIDWGYDVRNEMFFKKLEEVVTMAEDYVYRNVTVERDQLDTSG 547  Pyrobaculum aerophilum
Q8ZWL1  108 LKAVTLALPTLHKLRDALAEFADAFKAVSGEAIKRKFGIGLAYDVRNESFSKKLEEIITMAEDYVYRNVTVERGPLDTSG 187  Pyrobaculum aerophilum
Q8ZWQ5  108 LEAVTPALPALHELRDALTEFADAFKVVTREAVKRKFGIDWGYDVRNEMFFKKLEEVVTMAEDYVYRNVTVERWPLDTSG 187  Pyrobaculum aerophilum
Q8ZZA1    2 PEALVPELPTLHGLRDALAEFADAFKVVTREVVKRKFGINWAYDVRNENFFKKLNEIIAMVENYVYRNIAVERGPLDTSG 81   Pyrobaculum aerophilum

Q8ZXL7  548 SHPKTVIRFKLD-GEEIASINVYWTGKVLHAKFAGSREKAERLASILRALGGQAEVKRV-GKRWVVQLYTDGIAAIRHGD 625  Pyrobaculum aerophilum
Q8ZY42   82 RWPKAIIRFKLG-GEEVAYIIMYWTGNRPLAQFRGSREKAERLASVIRALGGEAEVKHVkGAGWVVQLYTDGITAIRHNG 160  Pyrobaculum aerophilum
Q8ZWR5  527 QWPKAIIRFKLN-GEEVAHITVYWTGTELYAKFGGSRENAERLASIIRALGGEAEVKRV-SKVWKVKLYTDGIASIRHNG 604  Pyrobaculum aerophilum
Q8ZYB9 2488 VDPWVEVRFKDDrGNEIAHINIRWNGEKLRAEFTGAKEKAERLASILNALGASVEAKEL-GGEWRVQLTTDSITAIRRKE 2566 Pyrobaculum aerophilum
Q8ZWY1  788 ----VTVVFKDErGDEIAHINIRWDGESLHANFEGMRKRAEQLVSILSAMGAKVKVKEY-SGKWRIELTTDSITAIRRKE 862  Pyrobaculum aerophilum
Q8ZSX1  262 TIPYVTLLFWEDsWREFARIYIKWCRNKLCAYFRGAKEKAKRAASVLSALGATVIVKKY-DGEWRVALKADSITAVRRTE 340  Pyrobaculum aerophilum
Q8ZVI5   82 SYPKTVIRFKLG-GEVVAHINMKWTGRYLLAEFRGSRENAERLASIIRALGGEAEVKRV-GEGWVVWLTTDGITAIRHDG 159  Pyrobaculum aerophilum
Q8ZVL1   81 DYPKTVIRLKLG-GEEVAYINMYWTGMALQAKFVGSRENVEHLASIIRALGGKAEIKRM-GNGWGVELTTDGIIAIRHNG 158  Pyrobaculum aerophilum
Q8ZWN2  188 SYPKTVIRFKID-GQEVAHINVYWTGSELQAQFIGSRENADRLASIIKALGGVAEVKPL-EGKWVVQLTTDGIIAIRHDG 265  Pyrobaculum aerophilum
Q8ZVU0  548 QLPKTVIRFKLG-GEEVAYITVYWTGSKLLAQFDGSREKAEQLASIITALGGKAEVKPK-NAKWTVHLHTDGIIAIRHDS 625  Pyrobaculum aerophilum
Q8ZWL1  188 RLPKIVISFKLG-DEEVAHITVYWRGDELYAQYGGSRESAERLASVIRALGGDAEVKYVkGAGWVVKLTTDGIITIRHDG 266  Pyrobaculum aerophilum
Q8ZWQ5  188 KQPKAVIHFKLG-GEEVAYITVYWTGRELQAQFGGSHENAERLASIIRALGGKAEVKRI-GKVWRTWLTTDDIIAIRHDG 265  Pyrobaculum aerophilum
Q8ZZA1   82 QWPKTVIRFKLG-GEEAAHITVYWTGSKLQAVFSGSRENAERLASIIRALGGEVEVKPH-GYGWIVWLTTEGIIAIRNNG 159  Pyrobaculum aerophilum

Q8ZXL7  626 WLKAVRGFVDELKD------KGLISENRYDQLMRDLEAGPNTVKFAGVEFTVNYRg---qSDKIHVRYHPGSEASKNAIV 696  Pyrobaculum aerophilum
Q8ZY42  161 WLNAVRSFVDELKD------KGLISDERYKQLVKEIETGPNVAKFAGVEFSAHYT-----NRGIQVNYQPRSEASKDAAL 229  Pyrobaculum aerophilum
Q8ZWR5  605 WLNAVRSFVDELKD------KGLISENRYKQVVKEIETGPNTVKFADVEFSVNYKtrdkySDIIQVRYTPTSEASKNAAL 678  Pyrobaculum aerophilum
Q8ZYB9 2567 WLEAVKALVEELHR------RGMVNERQRDRLLTEINAGPNVVEIANVELSVRAPtt-nkFKRLEIVYQPRSAKAFDAAV 2639 Pyrobaculum aerophilum
Q8ZWY1  863 WLDAVRTLIEELHN------KDIINKRQRERLLNEISAGPNVVEIAGVELSVMEIrt-ekRRGLIIIYHPRSANTFDTAM 935  Pyrobaculum aerophilum
Q8ZSX1  341 WLDAVRALVEELHR------RGIISGRQRRRLLREIDAGPNVVEMAGVEFTVRTK-----GRQIIIKRESLLAEVINSTV 409  Pyrobaculum aerophilum
Q8ZVI5  160 WLNAVRGFVDELYG------RGLIGEERYKQLVKDVAAGPNVVKLAGAEFSVYYGt---gMKSIMIVYNPRSEASKNAAL 230  Pyrobaculum aerophilum
Q8ZVL1  159 WLNAVRSFVEDLREygkrhgKELINKERYEKIIKDIEAGPNTVKFAGAEFSVYYK-----GSKIMVEYQPTSETSKNAAV 233  Pyrobaculum aerophilum
Q8ZWN2  266 WLNALKGFVEGL--------KGLISEDRYKQLVKDIEAGPNTVKFAGAEFSVYYEt---gVKRIKVKYQPSSEASKNAAI 334  Pyrobaculum aerophilum
Q8ZVU0  626 WLNAVKGFVDELYS------KGLISEDRYEQLVRDIATGPNTVNYAGVEFSVYHKte-gkYDFLEIRYHPGNEASKNAVV 698  Pyrobaculum aerophilum
Q8ZWL1  267 WLKALREFIDELHDdkr-hgKKLISDERYEKLIKNIEAGPNIVKFSGVKFSVYYEt---rMKNIMVEYQPRNDNAKNAAV 342  Pyrobaculum aerophilum
Q8ZWQ5  266 WLNAVRGFVDELYG------KGLIDKDKYEQLVRDLETGPNTVKFAGVEFTVNYE------NKIMVKYHPRNENAKNAAV 333  Pyrobaculum aerophilum
Q8ZZA1  160 WLNAVKSFVDELYS------KGLIDKDRYERLVKDIEAGPNTVKYAGIEFSVVYK-----SKGIEVRHQPRSEASKNTAV 228  Pyrobaculum aerophilum

Q8ZXL7  697 DTLKARGLKEGVHFTVNIVGAerYEIRVTKEAYAKAVEALAQSGLREGEHYSVYGKRREIRVRAEHKDAVINALKGAGLE 776  Pyrobaculum aerophilum
Q8ZY42  230 NALKARGLKEGIHFTVKEYGG--YEIRVADEFYAKALEALAHSGLREGEHYAVYGKRREIRVKAEQKDAAVNALKAAGLE 307  Pyrobaculum aerophilum
Q8ZWR5  679 NALKARGLKEGIHFTVKEHGG--YEIRVTKEAYAKAVETLAQSGLKKGEHYAVYDKRREIRVKKDHKDAIVNALKAAGLA 756  Pyrobaculum aerophilum
Q8ZYB9 2640 NALRDAGFVEGVHFTAKKPEG---------------------------------GKLGHVYIKLPA-------------- 2672 Pyrobaculum aerophilum
Q8ZWY1  936 KTLRRAGFVEGVHFTAKRPQG---------------------------------GKYGHVYIKIPA-------------- 968  Pyrobaculum aerophilum
Q8ZSX1  410 ETLKSAGLEEGAHFIAKRPDG---------------------------------SSLGYVYISVPT-------------- 442  Pyrobaculum aerophilum
Q8ZVI5  231 NALKAKGLKEGEHFTVTERGG--YEIRVADEFYAKALEAL--SGLKEKEHYAVYGKRREIRVKKDHKDTVVNALKAAGLE 306  Pyrobaculum aerophilum
Q8ZVL1  234 STLRAKGLREGEHFTVTKQGV--YEIRVTGESYAKAVEALAQSGLKEGEQYAVDGRRHVIRVKAEHKDAVVNALKAAGLG 311  Pyrobaculum aerophilum
Q8ZWN2  335 NALKARGLEEGRHFTVTEQGG--YEIRIADESYTKAVEALARSGLREGEHFTIDDGKRVISVKKDHKDAVINALKTARLK 412  Pyrobaculum aerophilum
Q8ZVU0  699 NALKARGLKEGVHFTVKEYGD--YEIHVAVESYTKALEALARSWLRKGEYYAIDDRKRVISVKAEHKDAVVNTLKTAGLE 776  Pyrobaculum aerophilum
Q8ZWL1  343 DALKARGLKEGVHFTVNTVGAgrYEIRVTKEAYAKAVETLAQVGLKEGEHYAVYDRWRIISVKAEHKDAIVNALKAAGLE 422  Pyrobaculum aerophilum
Q8ZWQ5  334 NALMARGLREGVHFTVTTEGTerYEIRVTKEAFVKAIDALVHSGLEEGKHYSVYGKWRIISVKAEQKDVIVNALKAAGLK 413  Pyrobaculum aerophilum
Q8ZZA1  229 DALKARGLKEGVHYTVNTVGAgrYEIRVTKEAYAKAVETLAQVGLKEGEHYAVYDRWRIISVKAEHKDAVINALKGAGLE 308  Pyrobaculum aerophilum

Q8ZXL7  777 EGKDFTVRSGGVYTIYITYDGLREIQRMALNGDLEAEKFIRELEDVLKRRHGDDAVKKLIEILTPAREEGTID-LPLTVY 855  Pyrobaculum aerophilum
Q8ZY42  308 EGKHFAAKWNGQYIIRITYDGLREIQRMALSGDVEAERFIRGLEDVLRRRYGDNAVKKLIEVLSPAREEGTLD-LPLAVY 386  Pyrobaculum aerophilum
Q8ZWR5  757 EGKHFAVKWSGQYIIYITYDGLREIQRMALGGNVEAERFIRELEDVLKRRHGDDAAKKLIEVLTPAREEGAAE-LPLAVY 835  Pyrobaculum aerophilum
Q8ZYB9 2673 --------------------GLWRLVELRRQGVDWADKALRRLEEIAKAR-GFYDLLE--EYLRPAMEAETVDpRGLVAE 2729 Pyrobaculum aerophilum
Q8ZWY1  969 --------------------GLWKLEELKRQGVEWAKRALKRLEEIAKAR-GFYDLLE--GYLKPAREAETVDpRGLVVE 1025 Pyrobaculum aerophilum
Q8ZSX1  443 --------------------GLWQLEELRRQGIDWADRALKRLEEIAKAR-GFYDVLQ--KHLRLAREAETVNpRGLVVE 499  Pyrobaculum aerophilum
Q8ZVI5  307 EGKHFAAKWNGQYIIRITYDGLREIQRMALNGDVEAERFIRDLEDVLRRRHGDDAVKKLIEVLTPAREEGAID-LPLEVR 385  Pyrobaculum aerophilum
Q8ZVL1  312 EGKHFATRSSGHHVIHITYDGLREIQRMALKGDVEAEHFIRGLKDVLKRRYGDDAVKKMIEVITPAREEGTIE-LPLAAR 390  Pyrobaculum aerophilum
Q8ZWN2  413 EGRDFTVKWSGHYVIHITYDGLREIQCMALGGDKEAARFIRKLKDVLERRYGQDAVNKLNDVLKPAREEGTVD-SSLPVY 491  Pyrobaculum aerophilum
Q8ZVU0  777 EDRHFTVKWDGYYVIRITYEGLREIQRMALNGDVEAERFIRELEDVLRRRHGQNAVKRLIEVLTPAREEGTID-LPLEVR 855  Pyrobaculum aerophilum
Q8ZWL1  423 EGKDFAVKWGGYYDIRITYDGLREIQRMALNGDLEAERFIRELEDVLRRRYGDDAAKKLIEVLTPAREEGTAE-LPLTVY 501  Pyrobaculum aerophilum
Q8ZWQ5  414 EGRDFTVKSSRYYVVYITYDGLREIQRMASNGDMEAEKFIRELEDVLRRRHGDGAAKKLTEVLRPAREEGTVD-LPLAVY 492  Pyrobaculum aerophilum
Q8ZZA1  309 EGKDFTVRSGGVYTIYITYDGLREIQRMALNGDLEAERFIRELEDVLRRRYGQNAVNKLIEVLTPAREEGAID-LPLAVY 387  Pyrobaculum aerophilum

Q8ZXL7  856 DDRGNLIARVVDLKYEFVKgkrkgrrsTGQPVNQCAGEDCRLRVIVEYEV-GGERRQLKMEWYWSKVQKKKGETTVTYFF 934  Pyrobaculum aerophilum
Q8ZY42  387 DERGNVVARVVDLRYEFVKgkrkdkqpAGQPVSHCAGEDCRLRVVVEYELpSGERRQFKMEWYWKKQQKKKGKTTATYYL 466  Pyrobaculum aerophilum
Q8ZWR5  836 DEGGNLIARVVDLRYEFVE--------NGQPVSHCAGRDCRLRIIAEYEV-GGERKQFKIEWYWKKQQKKKGNTTTTYYF 906  Pyrobaculum aerophilum
Q8ZYB9 2730 DVERGMRAVVKDVKATW--------------------EGGKPRVVVEYEV-GGDAKSFFFTW------------------ 2770 Pyrobaculum aerophilum
Q8ZWY1 1026 DAEKGIRAVIRDVKVVR--------------------EGNRSMVVVEYET-SGEVKSFKFAW-----------NVVTTSG 1073 Pyrobaculum aerophilum
Q8ZSX1  500 DPGAGVRAEIRDVRVEW--------------------TGRRPRVVIEYEA-GGQIKSFSFIW-----------GLKT-RR 546  Pyrobaculum aerophilum
Q8ZVI5  386 DDKGNIIARVVDLRYEFVE--------NGKVVNQCAGEGCRLRIIAEYEA-GGERRQLKVEWRWAEKREKRGKTTVTYYY 456  Pyrobaculum aerophilum
Q8ZVL1  391 DEKGSVVARIVGLKYEFVE--------NGKPVSQCSGKDCRLRIIAEYET-GAEREQFKMEWYWKKKLEKRGGTTITYYY 461  Pyrobaculum aerophilum
Q8ZWN2  492 DDRGNLIARVVGLKYEFVK--------GNQPVGQCAGEDCRLRIIAEYEA-GGERRQLKMEWYWARKREERGKTTVTYYY 562  Pyrobaculum aerophilum
Q8ZVU0  856 DERGNVVARVVDLRYEFVM--------GDQPVGQCAGEDCRLRIIVEYET-EGERRQLKIVCYWVKKQKEKGNATVTYYY 926  Pyrobaculum aerophilum
Q8ZWL1  502 DERGNLIARVVDLKYEFVE--------NGQPVSHCAGRDCRLRVVVEYELpSGERREFKMEWYWAEKRKKKDNTTVTYYY 573  Pyrobaculum aerophilum
Q8ZWQ5  493 DDRGNLIARVVDLKCEFVKgkqrskrlASQPVSQCAGEDCRLRIIVEYELpSGERRQFKMEWYWAEKREKKGDAIITYYY 572  Pyrobaculum aerophilum
Q8ZZA1  388 DDKGNLIARVVDLRYEFVE--------NGQPVSQCAGEGCRLRIIAEYEA-GGERRQLKVEWYWSKVQKKKGETTVTYYY 458  Pyrobaculum aerophilum

Q8ZXL7  935 EIARPTVKDDVEVAVLKTLTG----KAKRGEVYLLADQLDALRRFKPLRDA-VDKWREGRP 990  Pyrobaculum aerophilum
Q8ZY42  467 ESARPTIKDDVEVAVVKALTKr---KVEKGQVWLHADQLEALRRFKALKDA-IDQWRAGKP 523  Pyrobaculum aerophilum
Q8ZWR5  907 EMATLTVKDDVEAAVLKALTG----KAKRGRVFLLADQLDALCRFKALKDA-VDQWRRGKL 962  Pyrobaculum aerophilum
Q8ZYB9 2771 -------------------------RVKTG---------------GGGGYS------RSEA 2785 Pyrobaculum aerophilum
Q8ZWY1 1074 AVIASIRLNEEKAIVLVALTGdetiKKKRGSVQLSAKHLFALARLRGIGWE-LLRWYTEVM 1133 Pyrobaculum aerophilum
Q8ZSX1  547 AIVATVKLNAERALLLAALTGdgrlKGKRGALQLHAKHLLALTKYKGVGLSpVFSLPVSRL 607  Pyrobaculum aerophilum
Q8ZVI5  457 ETARPRVKDDMEAAVLKALTG----KAKRGEVWLLAEQLDALRRFKALRDA-VDKWRAEKP 512  Pyrobaculum aerophilum
Q8ZVL1  462 EIAVIYLKDVVEVAVSKALTG---------------------------KDV-KKAMCNSMP 494  Pyrobaculum aerophilum
Q8ZWN2  563 EIARPTVRDDVEVAVLKALTG----KARKGRVALLADQLDALRRFKPLKDA-IDQWREGRP 618  Pyrobaculum aerophilum
Q8ZVU0  927 EAAWSRVKNDVEAAVLKALTG----KAKRGRVQLFSSDLDTLYRFKALKDA-VDKWRGGKP 982  Pyrobaculum aerophilum
Q8ZWL1  574 ETALTTVKDEVKAAVLKALTG----KAKRGQVRLLADQLDALRRFKALKDA-IDKWRGGKP 629  Pyrobaculum aerophilum
Q8ZWQ5  573 EIARPTVKDEVEAAVLETLTGk---EAKRGRVYLYADQLDALRRFKALKDA-IDKWREGKP 629  Pyrobaculum aerophilum
Q8ZZA1  459 EAAWPTVKNDVEAAVLKALTG----KAKRVKVCLLADQLDALRRFKALKDA-IDQWRRGIP 514  Pyrobaculum aerophilum
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