Conserved Protein Domain Family
RabGGT_insert

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pfam07711: RabGGT_insert 
Rab geranylgeranyl transferase alpha-subunit, insert domain
Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP.
Statistics
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PSSM-Id: 400176
View PSSM: pfam07711
Aligned: 11 rows
Threshold Bit Score: 150.216
Threshold Setting Gi: 229292795
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007233482 265 LISCVYVSREGERVAVAFSKPVNAL---TEGLMLVLDGqQQQRVEWRSAHPRFRHSPVWLCELPPGSVSDINNEH-NLTV 340 Mexican tetra
1_pfamImport   1 MISCVYVSREEGRVAVAFSRPVNVRkkmCVNLLLVLDG-QPQRVEWRSVHPRLKHSPVWICDLPPGAISDAVNEH-NLTV 78 
NP_001070131 259 MISCVYASREGERVSVAFSKPVHAG---SVGLMLVLDG-QPQQVQWRNAHPRLRHSPVCLRDLPAGSISDTSNEH-NLTI 333 zebrafish
EEN63458     242 SIRCLHVCRPLNRLVATFSKHLKAS---AATLNVVKDG-EVITGRWHTPRGTDTFEQVLIFEFPEHSLTPDRDQHiHVTL 317 Florida lancelet
3_pfamImport   1 SITCLYASWDMGQLVVGFSRPVNVLl-eSSELVLFVDG-RPTPVKWQNPRKTQSYSCVWVSVLRTVGLQSGAPIM-TFFC 77 
XP_016852482 126 TIRCVYVNREDTSLAVAFSHPVAIAp-aSHDLIIFGDE-SPLVVRWRTPDGRNRPGFMWLCDLPASALNDHWPQH-TFRI 202 green anole
XP_008533653 244 ALRCLHVSRDEACLTVSFSRPLLVG---SGTLLLMVDE-SPLAVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQH-TFRV 318 Przewalski's horse
XP_003755932 244 AIRCLHVSRNEACLTVCFSRPIIVGp-gIETVMLLVDE-SPLPVEWRTPDGKKRPNHVWLCDLPADSFNDQDSQH-SFFL 320 Tasmanian devil
XP_028934266 244 AVLCLHVSRDDACLTVGFSRPLAVGp-gAERLLLLVDE-SPLAVEWRTPDGRNGPGNVWLCDLPAAslNDQWPQH-TFRL 320 platypus
KAE8633382   242 SIRCVMVSLDEPCVSVTFSHPVEV----QEDLILFLNN-RPIFVSWRTAGRKEKRSLFWVCDLPKECINDPCCQY-NFQV 315 tropical clawed...
XP_026161086 262 MISCVYVSRDEERVAVAFSRPVNAQ---LVGLMLVLDG-QPQRVEWRSVHPRFKHSPVWICDLPPGTISDITNEH-NLTV 336 zig-zag eel
XP_007233482 341 HWMEKHTHRDCALYTGRPESWCRDSA 366 Mexican tetra
1_pfamImport  79 HWTEKRTRRDCALYTGRSQSWCRDSA 104
NP_001070131 334 HWTDKHTHRDCALYTGCAESWCRDSA 359 zebrafish
EEN63458     318 DTEAGLVGRECVLGAGHPEVFSRDit 343 Florida lancelet
3_pfamImport  78 VWGGGQYNKECILYPGRTETWCRDSA 103
XP_016852482 203 LWSEGQSQKECVLFKGHRDCWSQDSv 228 green anole
XP_008533653 319 IWTAGDAQKECVLFKGRQETWCRDSA 344 Przewalski's horse
XP_003755932 321 MW--GDVQKECVLYKGRKESWCRDSA 344 Tasmanian devil
XP_028934266 321 LWRGGDAQKECVLFKGRREGWCRDSA 346 platypus
KAE8633382   316 LWKDGEAKKECILYPGRRESWFRDSA 341 tropical clawed frog
XP_026161086 337 HWTEKHTHRDCALYTGRTESWCRDSA 362 zig-zag eel
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