5EPV


Conserved Protein Domain Family
HWE_HK

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pfam07536: HWE_HK 
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HWE histidine kinase
Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria. The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as pfam00512. The family was defined by the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to pfam02518. These proteins are found in a variety of alpha- and gamma-proteobacteria, with significant enrichment in the rhizobia.
Statistics
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PSSM-Id: 400083
View PSSM: pfam07536
Aligned: 33 rows
Threshold Bit Score: 87.322
Threshold Setting Gi: 81740003
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5EPV_C    23 EIAHRFKNSMAMVQSIANQTLRNTYDPEQANRLFSERLRALSQAHDM----LLKENWAGATIQQICATALAPFNST-F-- 95  Brucella abortus 2308
Q92KT1   376 EVAHRAKNQLTVIQSMLAQSANSAEEPSDFVEAFRKRLAGLARSTDL----MVANAASGVDFRELVRNQLQPFMPA-E-- 448 Sinorhizobium meliloti
Q88HJ2   520 ELNHRVKNILSLIGALVAHPTPESQTLQDYVATLKGRIQALSLAHDQ----VVRGD-GGGRLAKLLEAELSPYRT--A-- 590 Pseudomonas putida ...
Q89BV9   213 EMSHRIKNLFSVADSMVRMTARNAATKEELAETLSGRLHALAQANGLirrsFGSDVAAVASLSDLVERILRPHE------ 286 Bradyrhizobium japo...
Q89UF6   347 ELNHRVKNILAVIQSIVTRTLRHGADIDGARELLIGRIHAMSNVVSL----LSESQWQGVKLKGLFEARAIPH------- 415 Bradyrhizobium japo...
Q92XW3   153 ELNHRVKNILASISSIFQMTRRRAVSLDEFAEDFAGRLAALANVHSA----VFQADGEAVEFSSVVELTFSPYRVR-G-- 225 Sinorhizobium meliloti
AAK90465 155 ELNHRVKNILATVTSIFQMTRRGAASVEELAGDFGARLQALSGVHSA----VFEAGGEEVGLSLIMATTVAPYNGD-G-- 227 Agrobacterium fabru...
Q89CT7   164 EAEHRSKNILANVQAIINLS--QSDTSERLKEVISGRIQAMANVHSL----FVETRWIGAEVSAIAKQELAPYLQEgQ-- 235 Bradyrhizobium japo...
Q9A3Z2   145 EVDHRAKNVLTVVQSLAQLT--PFESKDQYVQALSGRIGSLARAHSL----LSTTRWSGVDLHDLLELELDPYGGE-A-- 215 Caulobacter vibrioides
Q92ZE7   271 EMGHRLKNLFTILDSMVRISARSTDNKDDLVALLSGRLHALAAAHSLvkpsFSDVQGAASSLAELLSIVLEPHEQP-Ais 349 Sinorhizobium meliloti
5EPV_C    96 -ANRIHMSGPH 105 Brucella abortus 2308
Q92KT1   449 -SDRVVLSGPA 458 Sinorhizobium meliloti
Q88HJ2   591 -ADVIELQGPN 600 Pseudomonas putida KT2440
Q89BV9   287 -RQPSVLEGPD 296 Bradyrhizobium japonicum
Q89UF6   416 -ADRIAVTGPD 425 Bradyrhizobium japonicum
Q92XW3   226 -TDRLVFTGPT 235 Sinorhizobium meliloti
AAK90465 228 -SSRIAVSGPD 237 Agrobacterium fabrum str. C58
Q89CT7   236 -DKRIVMEGLQ 245 Bradyrhizobium japonicum
Q9A3Z2   216 -GEQIAILGPP 225 Caulobacter vibrioides
Q92ZE7   350 gKRRLSLTGPT 360 Sinorhizobium meliloti
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