2MSX


Conserved Protein Domain Family
MANEC

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pfam07502: MANEC 
MANEC domain
This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N-terminus with seven cysteines) it has now been renamed by MANEC (motif at N-terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.
Statistics
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PSSM-Id: 400058
View PSSM: pfam07502
Aligned: 54 rows
Threshold Bit Score: 80.8067
Threshold Setting Gi: 972957726
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MSX_A         2 ADCLNSFTa-GVPGFVLDTQASVSNGATFLE-SPTV--RRGWDCVRACCTTQNCNLALVELQPdrG-------------E 64 
XP_006627737  28 DGCPEAFVklTGQGL---DQQSFDNGASYSGhLPDV--SDEASCRQACCGHKECTLALLESTA----------------- 85  spotted gar
XP_002402128  54 rsvIESFQ--INENRIIRTEDSRRMGARYLN-ETQM--GSNRDCLFWCWQTSSCNVAVFEEKE--FakpplhvsehtfpA 126 black-legged tick
EDS42567      54 EMCLVRFD--VHLNTIIRTEESRAMGATFLD-DADV--NSREQCLRLCCETENCDVFVFEEKN----------------- 111 southern house ...
EDW03570      43 ESCIGHFD--VHKNTIIRTGESQAIGGKYLQ-GLEL--DTLEECERLCCETDACDVYIFERKA----------------- 100 Drosophila grim...
XP_001952847  26 fGCANRFE--VHDDKIIRTEDSKKLGAKFID-SVEQ--HDRAGCLELCCRTSRCDVFVFEEKS----------------- 83  pea aphid
OXU25300      38 QTCIDGFV--VHRDKIIRTQDSRDMGAKYLT-EFDV--ESRIECMKWCCETEHCDVFIFEEKK----------------- 95  Trichomalopsis ...
EEB18768      38 ETCIENFD--IHIDKIIRTQDSRAMGAKYLN-EADV--NGREDCMKLCCETSLCDVFVMEQKV----------------- 95  human body louse
EFX90112      84 GGCLEQSE--ISENTIIRTKDSRALGAKFLN-ETSLgaDARDRCLNLCCSFHGCNVAVYEEKD----------------- 143 common water flea
XP_002610026  44 PECEDLFR--TDLNQIIQTTKSLENKAVFLDsPMEM--VDQETCLETCCATDGCDTAVFESGG--Gag----------sA 107 Florida lancelet
2MSX_A        65 DAIAACFLINCLYEQNFVCKFAPREGFIN 93 
XP_006627737  86 GAPAECHLVSCLSAGRDVCVLTAKDGFTA 114 spotted gar
XP_002402128 127 QGKGSCYLFDCGPPSRFVCLFTAHRFYTv 155 black-legged tick
EDS42567     112 --QGTCFLFNCGPPSNFYCKFTHHSNYTS 138 southern house mosquito
EDW03570     101 --GGYCYLFECGPPENFHCKFTRHANYTS 127 Drosophila grimshawi
XP_001952847  84 --PGTCYLFECGPSDDFKCKFTNHKNYSS 110 pea aphid
OXU25300      96 --PGSCYLFHCGPPHDFKCKFTSHANYSS 122 Trichomalopsis sarcophagae
EEB18768      96 --PGSCYLFHCGSPEDFKCKFTQHKNYTS 122 human body louse
EFX90112     144 --GGNCYLFDCGPAEDFRCKFTSHSHYTS 170 common water flea
XP_002610026 108 DSSRNCYLFSC----QGRCSFASHSGYLS 132 Florida lancelet
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