5IY6,5XON


Conserved Protein Domain Family
TFIIS_M

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pfam07500: TFIIS_M 
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Transcription factor S-II (TFIIS), central domain
Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.
Statistics
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PSSM-Id: 400056
View PSSM: pfam07500
Aligned: 288 rows
Threshold Bit Score: 47.1505
Threshold Setting Gi: 122100556
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IY6_U       138 DSVRLKCREMLAAALRTGDdYIA--------------------------------IGADEEELGSQ-----------IEE 174 human
XP_001608856  34 NTYGKKLEECLIRGLEEIQ-NDSpdv---------------------------dmSECDVKILTNN-----------ICD 74  Babesia bovis T2Bo
KRH59876     339 DTHRDKCLEKLLQSVQFMF-NSDdsikkeekgndnsgaanngsnnkslesaneceDKVQKSSKPFVwpddavpavvaLEK 417 soybean
XP_009128670 309 DAHRDKCLAKLLEAVQNIC-YTAadetkvasdleq---------gekdaktengaHDNPLKDESFLwpdaavppvcaLEL 378 field mustard
XP_013608011 299 NSHRNECLAKLLEAVQSIC-FNAg-------------------------------DEA--NDESFLwpdaavspvcaLEL 344 Brassica olerac...
RID74084     304 NAHRNKCLAKLLEAVRNIC-SNAg-------------------------------DEA--NDESFIwpdaavhpvcaLEM 349 field mustard
XP_018509224 296 DAHRNKCLAKLLKAVQNIC-SNAgderklgsag------------shleqaesgsHDNPLKNESFLwpndavprvcaLEL 362 field mustard
XP_009134242 310 DAHRDKWLAKLLEAVQNIC-YTAenkeagdeakvgs-------dashleqadngaHKNMSKDESFLwpdaavppvcaLEL 381 field mustard
Q8RXT5       342 DAHRDKCLGKLLEAVQHIC-YIPenkqagdeakvgs-------dashleqdekdtKPENGKDEKFLwpdaavpqvcaLEN 413 thale cress
ERM95070     366 idnqeKGREALDESQKKN----------------------------------------QKGDASMRwpdtavnavtaLEK 405 Amborella trich...
5IY6_U       175 A---I--YQeirntdmkYKNRVRSRISNLkdAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRK-NLTKEAIREH 248 human
XP_001608856  75 VchdYygYDrr-----rFKQRMFEIYVNLkrENNQDLRRKILTKAMSVLDLVEADTIQLAPEELKHKRQiEVERHYIRNV 149 Babesia bovis T2Bo
KRH59876     418 A---S--HDtlssdyqkYNQKLRQLVFNL--KNNAILARRLLNGELEPSIILNMTPNELKEGLTAEETT-KKEPDESQHM 489 soybean
XP_009128670 379 A---L--HVslasdyhkYNQRMRALVFNL--KNTALLARRLLNGELEPAKILSMSPTELKEGLTAEETE-KNEPDDAEKM 450 field mustard
XP_013608011 345 A---I--NVsyasdyskYNQRIRTLAFNL--KNTALLAKRLLSGELEPEKISNMSPTELKVGLTNEETE-KNEPDDAERM 416 Brassica olerac...
RID74084     350 A---L--NVslasdhskYNQRIRSLVFNL--KNTALLARRLLNGQLEPEKILNMSPTELKEGLTNEETE-KNEPDDAERM 421 field mustard
XP_018509224 363 A---L--HVslasdyskYNQRIRALAFNL--KNTALLAKRLLNGELEPAKILKMSPTELKEGLTDEETE-KNEPDDAVRM 434 field mustard
XP_009134242 382 A---L--HAslasdyvkYNQKMRTLVFNL--KNTALLARRLLNGELEPAKILNMSPTELKEGLTAEETE-KKEPDDAERM 453 field mustard
Q8RXT5       414 A---S--HAslasdfqkYNQKMRTLVFNL--KNTALLARRLLNGELEPATILNMSPTELKEGLTADETT-KKEPDDADRM 485 thale cress
ERM95070     406 A---S--YEalgmdpmkYNQKVRQLSFNL--KNNPILAKRLLNKDLEASVILNMTPVELKDGLTAEEKN-PQEPQDVKHM 477 Amborella trich...
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