5OFB,5OFB,5OF9,4O62,2L7P


Conserved Protein Domain Family
zf-CW

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pfam07496: zf-CW 
CW-type Zinc Finger
This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found.
Statistics
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PSSM-Id: 400052
View PSSM: pfam07496
Aligned: 157 rows
Threshold Bit Score: 34.9589
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OFB_B       498 TTIQCD--LCLKWRTLPFQLsSVEKDyPDTWVCSMNP---DP--EQDR---CEASEQ 544 human
ESO09302     186 YWLRCN--ECFKWRMLPKETdINSDFiL-NFTCRS-----SK--RLGNv-tCDTDEN 231 Helobdella robusta
EEC20158      67 FWAQCT--RCHKWRRLPKGDdLTPEVvE-TFTCSDIPtyddseskiED---CDIPED 117 black-legged tick
ERE77441     138 YWVQCTkpECGKWRQLTKEIqLTPHMaR-TYRCGIKlntiTK--TDIPd-hCSLPED 190 Chinese hamster
XP_022527712 168 YWVQCTkpDCGKWRQLTKDIqLTASL-AASYRCGMKLn--NV--KTEGpdqCSQPED 219 Mexican tetra
XP_005452898 160 YWVQCTkpDCRKWRQLTKEIqLTASLaA-TYRCGMKfn-nIK--SEEPd-qCSQPED 211 Nile tilapia
XP_006011444 147 YWVQCIkpECRKWRQLTKEIqLTSVLaK-TYRCGMKlnnnVK--NEGPd-qCSFPED 199 coelacanth
OCA31260     138 YWVQCTklECGKWRQLTKEIqLTTQMaK-TYKCGMKmnnsVK--TEGSd-qCSMPED 190 tropical clawed frog
RAW37426     493 TTVYCD--SCKKARILSSEEaANAELnKDPWTCAn-----LA--KAGRsggCDAIDD 540 Phytophthora cactorum
XP_023352089 140 YWVQCTkpDCGKWRQLTKEIqLTSQMaQ-TYRCGTKpntsVK--VEGSd-qCSQPED 192 Tasmanian devil
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