2JOL,1R9K


Conserved Protein Domain Family
SopE_GEF

?
pfam07487: SopE_GEF 
Click on image for an interactive view with Cn3D
SopE GEF domain
This family represents the C-terminal guanine nucleotide exchange factor (GEF) domain of SopE. Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, can activate Cdc42, an essential component of the host cellular signaling cascade, in a Dbl-like fashion despite its lack of sequence similarity to Dbl-like proteins, the Rho-specific eukaryotic guanine nucleotide exchange factors.
Statistics
?
PSSM-Id: 400046
View PSSM: pfam07487
Aligned: 4 rows
Threshold Bit Score: 206.637
Threshold Setting Gi: 145579870
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2JOL_A        32 DAEF----GRQVYEATLCAIFSEAKDRFCMdpATRAGNVRPaFIEALGDAARATGLPGAD-KQGVFTPSGAGTNPLYTEI 106 Burkholderia ps...
Q7P1B7       107 DPVY----RRQALESTYATIYSEAKQAFYR--ANGGKMPEG-YLRELGEAARAAGLPGEN-KHGVFIPSGDGASPFVNYL 178 Chromobacterium...
WP_015874569 331 EAKYnqttRNQLIDAGLASVYAQKIDDFKKkyGESSETGQK-FLFEIGKVCKENGVKCTQnKNGTWVVNGAGAHPVIYPI 409 Candidatus Hami...
1R9K_A        35 DPAY----ARQTCEAILSAVYSNNKDQCCKllISKGVSITP-FLKEIGEAAQNAGLPGEI-KNGVFTPGGAGANPFVVPL 108 Salmonella ente...
2JOL_A       107 RLRADTLMGAELAARPEYRELQ----PYARQQAIDLVANALPAERSNTLVEFRQTVQTLEATYRRA 168 Burkholderia pseudomallei
Q7P1B7       179 LIPVQKEFGHRLRNESQQRLFR----DFARQLSMELVAPHAAERGWEPPAAFAARLEAVGRPWLAQ 240 Chromobacterium violaceum
WP_015874569 410 SQNIFTKFKMHLKLSNNKTKMYdksiSYITNKVYKKTDELCKQENRITTSDLRSLLDDVEKKVLDG 475 Candidatus Hamiltonella defensa
1R9K_A       109 IASASIKYPHMFINHNQQVSFK----AYAEKIVMKEVTPLFNKGTMPTPQQFQLTIENIANKYLQN 170 Salmonella enterica subsp. en...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap