4C5B,3LWB


Conserved Protein Domain Family
Dala_Dala_lig_C
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pfam07478: Dala_Dala_lig_C 
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D-ala D-ala ligase C-terminus
This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).
Links
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Statistics
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PSSM-Id: 429483
Aligned: 12 rows
Threshold Bit Score: 248.771
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4C5B_A 127 LWQGAGLPVAPWVALTRAEFEKGLS---DKQLAEISALGLPVIVKPSREGSSVGMSKVVAENALQDALRLAFQHDEEVLI 203 Escherichia coli K-12
O51218 136 LLKSFDIPLVPFIGFRQHDYFLDKE---EIKRNVKEVLGYPVIVKPAVLGSSIGINVAYSENQIESFIKEALKYDLTIVI 212 Borreliella burgdorfe...
O83676 143 LWQAAGLPVLPFVFFRKDAWRMHMQ---EFVAQLETRLGYPLFVKPAQAGSSVGASAVQTRAPLIPAIEAAFQWDEVVLV 219 Treponema pallidum su...
O66806 101 IVKSLGINTPDWETFISEGDVLNT-----------EWNKFPAVVKPVREGSSVGLKIVESLEELKEYALDLLKKTERVMV 169 Aquifex aeolicus VF5
O84767 569 FMSDLGIPVVPYLPLTLAGWKQEQD---KWLAHIVEAFSFPIFVKSSHLGSSIGVFEVHNVIELRDAINEAFMRDNDVFV 645 Chlamydia trachomatis...
P44405 106 LWKAFGLPVADMKVVTRETFSELD------PQAVVAKLGLPLMVKPSLEGSSVGLTKVKAVEELKSAVEYALKFDNTILI 179 Haemophilus influenza...
P0A6J8 147 LLRDAGLNIAPFITLTRANRHNIS------FAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYAIAVDLAFEFDHKVIV 220 Escherichia coli K-12
Q47758 138 LLQTVGIPQVPFVPVLRSDWKGNPK---EVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIV 214 Enterococcus faecalis...
P73632 134 VFERAGLPQVNYMGVERGEIWSNPCvfpALCEKIEAQVGYPCFVKPANLGSSVGIAKVRNRSELEAALDNAASYDRRIIV 213 Synechocystis sp. PCC...
P96612 135 LFAQVGLAQAKYAAFLKKDWTRSPK---ESCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVV 211 Bacillus subtilis sub...
3LWB_A 158 LLAADGLPVGAYAVLRPPRSTLHR--------QECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVARARRHDPKVIV 229 Mycobacterium tubercu...
Q06893 138 LTKNAGIAVPEFQMIEKGDKPEAR------------TLTYPVFVKPARSGSSFGVTKVNSTEELNAAIEAAGQYDGKILI 205 Enterococcus faecalis...

4C5B_A 204 EKWL-SGPEFTVAILG-----EEILPSIRIQPSG------TFYDYEAKYLS----DETQYFCPAGLEASQEANLQALVLK 267 Escherichia coli K-12
O51218 213 EKFI-EAREIECSIIGne--kMKIFSPGEVVVQDf-----IFYDYDAKYSVip-gNSIIFNIPAHLETNQLLSIKEYAFL 283 Borreliella burgdorfe...
O83676 220 ERYV-RAREIECALSGng--pYTVHGAGEVIAQG------AFYDYEEKYad---aSVARVLVTAPLETAQYEQITTLALR 287 Treponema pallidum su...
O66806 170 EEFV-EGRDMTVGILK-----GEALPVVEIIPKK------GVYDYECKY------TKGMSEYRILKDEKLSKKLQEISLK 231 Aquifex aeolicus VF5
O84767 646 EENRlGCKEIEVSVLGdgsgaFVVAGLHERRGSG------GFIDYQEKYGLsg-kSSAQIVFDTDLSKEIQEQILEAADK 718 Chlamydia trachomatis...
P44405 180 EEWL-AGDELTVPVLD-----NQVLPAIRIVPEG------EFYDYEAKYIS----DNTQYFCPAGLTPEREQALSTLVKR 243 Haemophilus influenza...
P0A6J8 221 EQGI-KGREIECAVLGnd--nPQASTCGEIVLTS------DFYAYDTKYid---eDGAKVVVPAAIAPEINDKIRAIAVQ 288 Escherichia coli K-12
Q47758 215 EQGI-EAREIEVAILGne--dVRTTLPGEVVKDV------AFYDYDAKYi----nNTIEMQIPAHVPEEVAHQAQEYAKK 281 Enterococcus faecalis...
P73632 214 EAGLtDIREVECAVLGne--nPQASVVGEITYDS------DFYDYETKYt----dGRSQMHIPANLPKAVVNQIQTMAIQ 281 Synechocystis sp. PCC...
P96612 212 EEGI-NGREIEIGVLGnd--dPKCSVVGEIAPKT------DFYDYKAKYe----dGDTDLMIPAIVTDEEYATISDMAIK 278 Bacillus subtilis sub...
3LWB_A 230 EAAI-SGRELECGVLEmpdgtLEASTLGEIRVAGvrgredSFYDFATKYl----dDAAELDVPAKVDDQVAEAIRQLAIR 304 Mycobacterium tubercu...
Q06893 206 EQAI-SGCEVGCAVMGne-ddLIVGEVDQIRLSH------GIFRIHQENEPekgsENAMIIVPADIPVEERNRVQETAKK 277 Enterococcus faecalis...

4C5B_A 268 AWTTLGCKGWGRIDVML-DSDGQFYLLEANTSPGMTSHSLVPMAARQAGMSFSQLVVRILE 327 Escherichia coli K-12
O51218 284 TYKNLELRGMARVDFFVeKKSGTIYLNEINTIPGFTDISMFAKMCSNDGLQFKDLVDNLID 344 Borreliella burgdorferi B31
O83676 288 AYEALGLTGLARVDFFL-LETGEVYVNEVNTMPGFTSISLFPQICQAAGVAPQDLMAQLLS 347 Treponema pallidum subsp. pallidum str. ...
O66806 232 ISKFLSLKDFARIDFRV-TKEGKIFFLEVNTIPGMTELSLLPMAAKEKGMDFKKLISIIIT 291 Aquifex aeolicus VF5
O84767 719 IYRLLLGKGSCRIDFFV-DEEGNFWLSEMNPIPGMTETSPFLTSFIRKGWSYEQIVHQLVI 778 Chlamydia trachomatis D/UW-3/CX
P44405 244 AYDAVGCRGWSRIDVMC-DAKGNFRLVEVNTNPGMTSHSLFPKSAATVGISFEQLVVKILE 303 Haemophilus influenzae Rd KW20
P0A6J8 289 AYQTLGCAGMARVDVFL-TPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIE 348 Escherichia coli K-12
Q47758 282 AYIMLDGSGLSRCDFFL-TSKNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQ 341 Enterococcus faecalis V583
P73632 282 AFKAVDAAGLGRLDFFYqPTTGQIVINEINTLPGFTAFSMYPELWRASGVEFPSLVDRLLQ 342 Synechocystis sp. PCC 6803 substr. Kazusa
P96612 279 AFKAIDGSGLVRADFFL-TADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIEQLVE 338 Bacillus subtilis subsp. subtilis str. 168
3LWB_A 305 AFAAIDCRGLARVDFFL-T-DDGPVINEINTMPGFTTISMYPRMWAASGVDYPTLLATMIE 363 Mycobacterium tuberculosis
Q06893 278 VYRVLGCRGLARVDLFL-QEDGGIVLNEVNTLPGFTSYSRYPRMAAAAGITLPALIDSLIT 337 Enterococcus faecalis V583
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