1GL4


Conserved Protein Domain Family
G2F

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pfam07474: G2F 
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G2F domain
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.
Statistics
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PSSM-Id: 400037
View PSSM: pfam07474
Aligned: 69 rows
Threshold Bit Score: 191.983
Threshold Setting Gi: 859812936
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GL4_A         47 GSPQRVNGKVKGRIfvgssqVPVVFENTDLHSYVVMNHGRSYTAI----STIPETVGYSLLPLAPIGGIIGWMFAVEQDG 122  house mouse
EKC40013     3257 rlpgKAFGTLVGYI------NGVDLTESTINAVMTTTDDGQNIKVaatiKDLPPNVGRHVEHLVSVLSPVYWVTASERGG 3330 Pacific oyster
XP_001920501 3454 eSPRRARGSLIGMV------NEKEFGVAYLEANITENDLEGTSTLeahvENIPPSVGPLLRVLVSVFAPVYWTTVYQTQE 3527 zebrafish
XP_023350063 3742 GEPRGSRGSMVGVI------NGQEFGVASLNTSVLQEIEDGATTIqssiNNIPPDVGPLMRILVVAIAPIYWVLAGQSGE 3815 Tasmanian devil
A2AJ76       4431 GEPRGSRGSMTGVI------NGQEFGMATLNISVLQQGSSEAPTIwssiSQVPASVGPLMRVLVVTIAPIYWALARESGE 4504 house mouse
EEN47826       24 GRPTQAHGSIIGTV------NNLEFGVATLYANITKSRSGNHRVIav-mTNIPANVGFWLRKLVSILTPVYWTTAFEVGE 96   Florida lancelet
AAI57688      124 GGPQRVKGNLFGRI------NDLDFGMAPLNATITDDPNSGSRILqakfTNIPKSLGPSMRNLVSLLNPIYWTTAKEIGE 197  tropical claw...
XP_014351769 4083 GFPLRARGSLIGVI------NDKEFGVAFLNTNITENTDAGYTTVqgniENIPETVGPLMKVLVSVFAPIYWSVAYEKRD 4156 coelacanth
XP_026199076 3449 eaPRKTRGSLIGMV------NDREFGVSFLEANITDNVEEGSSTLqahlDNIPPSIGPLLRVLVSVFTPIYWTTVLQNGA 3522 climbing perch
XP_015222023 2895 aVPQRARGSLIGMV------NDREFGVAYLDANVTARPEDSGSRLqarvGNLPGAVGPLLRVLVSVFAPIYWTTVLQAGE 2968 spotted gar
1GL4_A        123 FKNGFSITGGEFTRQAEVTFLgHPGKLVLKQQFSGIDEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHYSSS-VITS 201  house mouse
EKC40013     3331 AKNGLSLTDGKFSRDVQVEYA-TGEIVRMSQYANGVDEDGVLQIDVIIRGVVPDLSQGAELTLTPYYENYIQTGQgNIFA 3409 Pacific oyster
XP_001920501 3528 TQNGFSITEGQFRQESQLEFE-TGEILKLTHVARGLDGEGVLLVDIVINGFVPPMLLSSNLNLQEFDESYVQTGSgQLYS 3606 zebrafish
XP_023350063 3816 ALNGYSLTRGNFRQESQVEFA-TGELLHLTQVARGLDRDGLLLLDVVVNGFIPEVLPTAHLQVQDFRERYVQIGPgELYV 3894 Tasmanian devil
A2AJ76       4505 ALNGYSLTGGSFQQESQMEFS-TGELLTMTQVARGLDPDGLLLVDMKINGMIPESLADGDLRVQDFQEHYVQTGPgQLFA 4583 house mouse
EEN47826       97 AVNGYTLTKGIFQRETQVEFP-TGETLHMTHNARGLDDSGVLQLDIVLKGDVPHLSSTANIILKDYVEDYVQTGPgQIYA 175  Florida lancelet
AAI57688      198 AVNGFSLTGGIFKRESQVEFA-TGEILKITHTARGVESDGSLLLDTVVKGNVLQLQTSVDIHLKDYTEDYIQTGPgQVHA 276  tropical claw...
XP_014351769 4157 TINGFSLTRGVFRQESQVEFA-TGEILRITQVARGLDADGVLLFDIVISGFMPKLLANSDVKVKDFSENYVQTGPgQLYA 4235 coelacanth
XP_026199076 3523 ARNGYSFTQGQFRQESQVEFE-TGEILRLTHVARGLDSEGVLLIDIVINGFVPPSLTSSHLNLQEFDESYVQTGQgQLYS 3601 climbing perch
XP_015222023 2969 SRNGFALTRGVFRQESQVEFE-TGEVLRLTHVARGLDAEGVLLVDIVINGFVPRALAGAQLTLQGFRESYVQTGPgQLYA 3047 spotted gar
1GL4_A        202 SSTREYTVMEPDQDgaapshthiYQWRQTITFQECAHDD 240  house mouse
EKC40013     3410 RSSRTIRMDGHLLP---------YSWNHSISYETTEimp 3439 Pacific oyster
XP_001920501 3607 WSTQNHIRDGAPLT---------LRCNHTMVFEGPESRq 3636 zebrafish
XP_023350063 3895 GSTQTFLKDGAPTD---------FHCNHTIKYDSALGpq 3924 Tasmanian devil
A2AJ76       4584 GSTQRFLHDSLPAS---------LRCNHSIQYDETRGLQ 4613 house mouse
EEN47826      176 FSTRMFTVDGHMQP---------YTWNHTIHYDSSLGQM 205  Florida lancelet
AAI57688      277 YSTRMFSVDGVYVP---------YTWNHTINYDAGQGTM 306  tropical clawed frog
XP_014351769 4236 WSTQRLRQEDSWMP---------FHCNHTVEYEASLGRQ 4265 coelacanth
XP_026199076 3602 WSSQTHQRGGNPMV---------LRCNHTIIYEGQEERQ 3631 climbing perch
XP_015222023 3048 WSSQRPLVNGAPVS---------LRCNHSVIYEAggarq 3077 spotted gar
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