2FGT


Conserved Protein Domain Family
YycH

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pfam07435: YycH 
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YycH protein
This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG. YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions.
Statistics
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PSSM-Id: 400011
View PSSM: pfam07435
Aligned: 5 rows
Threshold Bit Score: 478.902
Threshold Setting Gi: 81592974
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2FGT_A   2 ESTVRVKHK------IEKTTQKLSETVRPRDMFI--HDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISDQYDKAgf-- 71  Bacillus subtilis
Q8EKY2  35 LSERSVEGA------LNGVEKSVDDIVMPSEIIF--KQEGNYYTHATPNLKEQFYNSLQELRITEMERLPAEEERT---- 102 Oceanobacillus iheyensis
Q9K5R3  35 LDNENNYEEl----iRLEEERSMNEVIVPESMIVhgGDEEYYIVRPDLEQHKDFLATMSETTFID-DDMRVQHPFA---- 105 Bacillus halodurans
Q8YA70  36 INVKEVEKT------TIDKTMTTSQVFKPYKLAVnaNENNYQSL--DADLLNELMAQGKAFSFSEVVLASKKSSEDyekl 107 Listeria monocytogenes
Q5HK20  36 IDNTDNSKSdkpkplTKPMTAEMEGTITPFQIVHs-RDDKSQGTVASGAVLDKMIQPLKNQEVKSVSHLKREHNLVip-- 112 Staphylococcus epider...
2FGT_A  72 kSWFYGIggseaklDLQFSDTIPIDIF-QTLFKWSNQS--FEYSSFDHILIPFNETKA-NKKIYLVSYSKQLILEVTVES 147 Bacillus subtilis
Q8EKY2 103 -PSNYEI-------EVIFPQEVPFLLF-DRILQLEDEAapFPTFSIDRFYITFEPNSKsLQLEFISIDGREKVVAEVTST 173 Oceanobacillus iheyensis
Q9K5R3 106 -SAPTGI-------QLIYPTSIPSELF-VHLFDVEDEDflLPLTSINRIYFYVEPDEGvVAQLLSLFDEQVVTIKTDMSP 176 Bacillus halodurans
Q8YA70 108 iHKNGTI-------EIIFPNNIPFSIF-AQIFQVEGEG--LESAFFNRIVFDINKTDTgLHSVYFTNDDQENIYQSSLQN 177 Listeria monocytogenes
Q5HK20 113 eLSNNFI-------VLDFTYDLPLSTYlSQVLDIDAKV--PNNFNFDRLLIDQDHNNHvV--LFAISKDRHEVVKLKTTM 181 Staphylococcus epider...
2FGT_A 148 ANYRNIMNDLKNRQSNMPAFSLFSIGS-----KKEFLLPNKPLTMDKKEFVTESIKTNTFKQALFSDPSIV---RedSNY 219 Bacillus subtilis
Q8EKY2 174 ARYEEVWDEMNRLQSEDYQRMTLIEGT-----ENDFYIPREVPAMQPISIFFTQMNKSVLQEMLFENTSGI---R--GSA 243 Oceanobacillus iheyensis
Q9K5R3 177 SDLEALMEDTDDYMAATSIVMGMH--------QQSQYVPVDHTHLPTLSYTATMLSSMQFSQALFTDPSAVsmyH--QSN 246 Bacillus halodurans
Q8YA70 178 KDIDKIEKIVKKNESKLTQNDKLISN------KRNLFLSSEKTKLNRKKYIIDSLEINLFTSALFQDSGTV--------K 243 Listeria monocytogenes
Q5HK20 182 KG-NNVDKAFKSIEPDMQPYTEIITNKdtidkATHVFAPSKPKDLKTYRMVFNTISVERMNSILFDDSTIV---R--SSQ 255 Staphylococcus epider...
2FGT_A 220 NNRNVLTDGISRLDVNLSQRQVQFq-----qRNLVQSTSYQTGELIKKSQKYLEDTGSWTDH--YQFFNIn-DSQQLSFY 291 Bacillus subtilis
Q8EKY2 244 TPGNGYLYATDVRQLTIERNVMEY-------IYLEQPEAISDLNLIENSIQNINGHSGFTED--FRLMNI--DNNTITYQ 312 Oceanobacillus iheyensis
Q9K5R3 247 GKDDSYTDGNRIISEQGGGNFMEYt-----nPVFSETTERSGRHIIQASFDFINSHGGWTDQyiLDDWQSfgTRDLVSYR 321 Bacillus halodurans
Q8YA70 244 SEGNTYTDGSSVIEMDTDNKVLEYvnpsqerTNPEDLSSVKRAGLIQDSFNFVNDHAGWTGDgaYYFTGYaaESATTNFS 323 Listeria monocytogenes
Q5HK20 256 SGTTTYNNNTGVANYNDKDEMYHYk-----nLSEDAKSSSNMQETIPGTYEFINSHGGFLNEd-YRLFKTdnRTGKLTYQ 329 Staphylococcus epider...
2FGT_A 292 IFMDQIPVINSTAKPFgatSAITVQWANDDILSYKRPNYSLG-TNPIKTSETELMGGSEVKMLLSkQTAYDTDKIDQIFL 370 Bacillus subtilis
Q8EKY2 313 MYYDGHPVFQGSSSDI---STIKQTHSNQHLLEYKRPAIYLDtTDIIRKTKKEMRSGEEILEELV-DNEIDMDSVNDLKV 388 Oceanobacillus iheyensis
Q9K5R3 322 LRVNGFPVMSFQGEDLmklDLVRRGSGNQPT-EYRRPLFDID-NQPIDGGKKELPSGEEVLDALKeREDFNPRSLEKMVI 399 Bacillus halodurans
Q8YA70 324 LFIDNLQVYNENGM-----ADISVTEGLEAVYKYMRPFFRLDtDVPGEKKEVTLPSSYSVYSALAqNPNVKAEEIEDIVP 398 Listeria monocytogenes
Q5HK20 330 RFLNGHPTFNKHNF-----NEIQVTWGDKGVYDYQRSLLKTD-VTLNSEESKSVPTVESVRSALAnHPDIDFEKVTNIAI 403 Staphylococcus epider...
2FGT_A 371 AYQLVSTS-TNDDp---LVELEPVWAMKVNGKIVPITkdLLRKEGANSGVE 417 Bacillus subtilis
Q8EKY2 389 GYKIQVETdDNGD----YVSMEPEWFMKINNNWSAVP--YYQPGAAAKGGD 433 Oceanobacillus iheyensis
Q9K5R3 400 GYEMVKPS---------YVIAEPFWFVKYDGRWEKID--LTAKEEATDGLE 439 Bacillus halodurans
Q8YA70 399 GYHMTRSEsSGMNr---LVTLEPTWLYKYHDKW------FIFQPDAEKAGE 440 Listeria monocytogenes
Q5HK20 404 GYDMDDKAnNEDIevqrNCELIPRWFVEYDGNW------YAYKDGrle--- 445 Staphylococcus epidermidis RP62A
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