1XC0


Conserved Protein Domain Family
Pardaxin

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pfam07425: Pardaxin 
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Pardaxin
This family consists of several Pardaxin proteins. Pardaxin, a 33-amino-acid pore-forming polypeptide toxin isolated from the Red Sea Moses sole Pardachirus marmoratus, has a helix-hinge-helix structure. This is a common structural motif found both in antibacterial peptides that can act selectively on bacterial membranes (e.g., cecropin), and in cytotoxic peptides that can lyse both mammalian and bacterial cells (e.g., melittin). Pardaxin possesses a high antibacterial activity with a significantly reduced haemolytic activity towards human red blood cells compared with melittin. Pardaxin has also been found to have a shark repellent action.
Statistics
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PSSM-Id: 116046
View PSSM: pfam07425
Aligned: 4 rows
Threshold Bit Score: 43.9234
Threshold Setting Gi: 129607
Created: 11-May-2020
Updated: 6-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XC0_A  1 GFFALIPKIISSPLFKTLLSAVGSALSSSGGQE 33 
P81862  1 GFFALIPKIISSPLFKTLLSAVGSALSSSGDQE 33  finless sole
P23067  1 GFFALIPKIISSPIFKTLLSAVGSALSSSGGQE 33  Pacific sole
P81866  1 GFFAFIPKIISSPLFKTLLSAVGSALSSSGEQE 33  Pacific sole
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