2WVR


Conserved Protein Domain Family
Geminin

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pfam07412: Geminin 
Geminin
This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Statistics
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PSSM-Id: 399999
View PSSM: pfam07412
Aligned: 22 rows
Threshold Bit Score: 235.013
Threshold Setting Gi: 1033401260
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WVR_A         1 MNPSMKQK--QEEIKENIKN--------SSVPRRTLKMIQPSA-SGSLVgRENELSAGLSKRKHRN-DHL-TSTTSSPGV 67 
XP_014352040   1 MTTNMKQKfdTDKPAVNIKSffs--sstNVAPRRTLQVLQPSAtSGCLVgRVPE-SRLIPKRKLWGaEQLkTCKKANTEA 77  coelacanth
XP_003444213   1 MNVSGKVKqsHQKSNENMKSlftpsqktMGPARQTLQVRQ----VNSDLgRSTQAGKVGPKRKNWTaEQIrGSKRVKMEV 76  Nile tilapia
XP_014331564   3 SVGNVKQR----SSNENVKSfsvpsqkvVREKRQSLQVLQHSA-VNTSL-KSAQTGKVIPKRKQWIlDQSrGSKRVKVEV 76  southern platyfish
5_pfamImport   1 ---------sHQRSNENVKRlfts-qnaMGCPRPTLQVLQQSA-GNKALgRSAQAGKVVPKRKQCNaEYTrGPKRVKVEV 69 
XP_011607766   1 MSSSGKPKsgLQASNENIMSffgpsqkaMGPSRQALQLLKDSA-ANKDPgRSTQ---AIPKRKQWSaTPTrGPKRVKVEV 76  torafugu
XP_007249364   1 MNSVRKMKq-GENPQENIKKfftaqtsgASSGRRTLQVLQPST-VNKGLgRTTEIGKAVPKRKLWSvDQVkGSKRAKAEV 78  Mexican tetra
Q1LU98         1 -mSSIRRPknAENPSENIKKflvaptsgAGMGRRTLQVLQPSA-VNKNLgRIIENGKAVAKRKMWSaEQVkGSKRVKAEV 78  zebrafish
NP_001098337   1 MTSSGKLQknHQRSNENIKTflapsqkqMEFNRKSLQILQPSA-ANTDL-RAAQAGKGIPKRKQWLaEQTrGPKRVKVEV 78  Japanese medaka
CAG11151       1 MSSSGKSTasHQSSKENIISffassqkaMGPTRQALQVLKDST-ANKDFgRSTQ---AIPKRKQWNaTQTrGPKRVKVEV 76  spotted green p...
2WVR_A        68 IV-PESsENKNL-GGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVA 145
XP_014352040  78 AVdPEH--NENViEGNQKEAYELMVKANPPSIYWKELAEERRKALYEALQENERLHKEVEHKDEEILKLKKENEELVELA 155 coelacanth
XP_003444213  77 KStQTE-AADGLiDGMSNEAYELMVKETPPSTYWKEVAEERRKALYNVLQENEKLHKSIEARDEQITKLQSENEELQELA 155 Nile tilapia
XP_014331564  77 KAtQTE-EVNCVpDGLSKEAYELMVKETPPSSYWKEVAEERRKALYRVLQENEKLHKDIEARDEEISKLQSENEELQELA 155 southern platyfish
5_pfamImport  70 KAtQTD-ETPCLsNDMSNDAYQLMVVETPPAAYWKVIADERQKALYNVLQENEKLHKDIEAKDDQITRLKCENGELQELA 148
XP_011607766  77 KStQTE-ESQCLvGGMSVEAYDLMVREAPSDNYWKELAEERRKALYDVLQENEKLHKDIEAKNEQITALKSENEELHELA 155 torafugu
XP_007249364  79 AVkITDpENENLpDGISQEAFELMVKETPSSAYWKEMAEERRKALFNVLQENEKLHKEIETKDEQIAQLKSENDELQELA 158 Mexican tetra
Q1LU98        79 AVkSTNaENENQpEGVTQEAYELMIKETPGSSYWKEVAEERRKALFSVLQENEKLHKDIEAKDEQIAQLKTENEELQELA 158 zebrafish
NP_001098337  79 KStQTE-DDCLPpDGVSSEAYDLMIKETPPASYWKEIAEERRKALFNVLQENEKLHKDLEVRDEQIRKLQSENEDLQELA 157 Japanese medaka
CAG11151      77 KStQTD-ESRCLvDGISTEAYDLMVKDTPTGDYWKELAEERRKALFDVLQENEKLHKDIEDKNERIAALKSENEELRELA 155 spotted green p...
2WVR_A       146 EHVQYMAELIERLNGEPLDNFESLDNQEFD-------SEEETVEDS 184
XP_014352040 156 EHVQYMANVIERLTGQNSDTLEALKNLDLD-------EDHQDAEED 194 coelacanth
XP_003444213 156 QHVQYMADMIERLTGKSPDNLDEVRGIALD--------EDDAEDED 193 Nile tilapia
XP_014331564 156 QHVQYMADMIERLTGKCPESLEEMKDIAFD-------AEEADPAEQ 194 southern platyfish
5_pfamImport 149 QHVQYMADMIERLTGASPENLEELREIALD-------VEEDGEEEH 187
XP_011607766 156 KHVQYMANMIERLTGMGPDNLEELRDMALE-------TEDTEQTGE 194 torafugu
XP_007249364 159 QHVQHMADMIERLTGKSPDNLEELREMAFD-------TVVEDDDNE 197 Mexican tetra
Q1LU98       159 QHVQHMADMIERLTGKSPDNLEELREIAFD-------AEDEELENE 197 zebrafish
NP_001098337 158 QHVQYMADMIERLTGKCPDNLDELKGITLDvvdsyehAEGEAEDHS 203 Japanese medaka
CAG11151     156 QHVQYMADMIE----------------------------------- 166 spotted green pufferfish
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