2P22


Conserved Protein Domain Family
Mod_r

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pfam07200: Mod_r 
Modifier of rudimentary (Mod(r)) protein
This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (pfam05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.
Statistics
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PSSM-Id: 399880
View PSSM: pfam07200
Aligned: 154 rows
Threshold Bit Score: 49.8866
Threshold Setting Gi: 387514982
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2P22_C        36 NLLSSKEIIDLIQTHrHQLELYVTKFNP--LTDFAGKIHAFRDQFKQL-EENF----E---------DLHEQKDKVQALL 99 
XP_013934365  44 NELSTAKLQELARSP-DLLQSYLYKTSNf-dQIGTEIVESLEKQIEYTtKLLKnv-kE---------DIVPQTDQINKQL 111 Ogataea parapol...
CAY68792      36 ssvpLSKLKELLDNQ-KLLKSYLL-----------DSLQEFNQEIIHTlDENIrslqNll------qQYEDNSKDIDQLN 97  Komagataella ph...
CCE40239      32 esLPTKTFEEFVNNE-ELIQGYI--------HQLEAYKSKL-KELQERaS-QAssllQseindtlipQYQDVSNKINQRI 100 Candida parapsi...
XP_002548307  35 etLPTSYLQDFSDNK-QLLQGYI--------RQLEAYSTKQ-QEVVRTlQ-QAddilEnvvysqlikDYEKVIDKINQQI 103 Candida tropica...
EMG46218      35 eaLPTANFQQFTENK-ELLQSYI--------KQLDTYQSKQ-QEIVNQlN-QLddflEnvvckklmnEYEELIEKINQQI 103 Candida maltosa...
Q6BSN3        22 dsLPVSIIEQFIQLH-SLVRGYI--------KQLPAYQKWN-ETIIETlNWQItnlnEiss---ilkTYNGTGTLIKEKM 88  Debaryomyces ha...
EGV65816      41 svlpagiIDKLTQQH-SIFLGFI--------KSQPQLQEYN-SDTMAFlDSQIhtinQvie---lveEYTQTSERINELI 107 Yamadazyma tenu...
EEQ40127      21 kNLPAQFLADFSRSY-ELVQGFV--------EELPKYRETQ-AQIVDVaNQQIelvnEivq---ileEYEAKSAHISRQL 87  Clavispora lusi...
XP_011273040  42 qSLPKDQLIKLIQSV-DVLKGYLITLNEknLQDNTVVLDGIVKDIESFiQKLQql-qK-------------SKDDLNKQL 106 Wickerhamomyces...
2P22_C       100 EN---ARILESKYVASWQDYHsEFS-KKYGDIALKKKLEQNTKKLDEESSQLETTTrsI-D----------SA-DDLDQF 163
XP_013934365 112 EQ---FHEKLKKFDQLQVRMY-DLL-NKYSRESIIRAVERSVNDKDRDTKSLVDQ---IrSspa-----eiDE-AQLASF 177 Ogataea parapol...
CAY68792      98 KSldeLNVLFRRWKQTEIEMY-TIL-QRYQPNSLSKKLFELLEQSHLESQQLVSKL--EgS----------VQeSDLQSF 163 Komagataella ph...
CCE40239     101 KT---LTQLHNEFLNLETIQY-QTMsSTFNEELLKHKFRKLIERNDEESRD----L--VkNins----sevTD-EQLVDT 165 Candida parapsi...
XP_002548307 104 KS---INIIYQEFINLETYQY-QLLsSNFNQDNLKAKFKKLIEENNQESLD----I--VkNfndrshgseiSD-ESFGTM 172 Candida tropica...
EMG46218     104 KS---INIIYQEFINLETYQY-QLLsSNYNQDNLKLKFKKLIEENNQESLN----I--VkKfhek--agenSD-ENFSTM 170 Candida maltosa...
Q6BSN3        89 AK---LNSLYSEFINLETYQY-QLLsSNFNQEFLKNKFHKVIVENDQESKK----L--VkEfkgs--ssddFE-NLFNNL 155 Debaryomyces ha...
EGV65816     108 KT---IKNVYTEFTDLEMIQY-KLLaENFNQDSLKAKFRKVIAAEDQESKA----F--IkEytnq--dtqvNS-SRLDEM 174 Yamadazyma tenu...
EEQ40127      88 KT---MEELYREFLNLETYQY-QSLsSNFNQNFLRTKFGRLAEASDKESVS----L--VrNkks------laE-SDLASF 150 Clavispora lusi...
XP_011273040 107 LS---LQALTSEWNSREVDMY-SSL-QKFGSKNLYSLLRTSVLESKKLTESISQSF--IqDsle-----khDE-ASIQNF 173 Wickerhamomyces...
2P22_C       164 IKNYLDIRTQYHLRREKL 181
XP_013934365 178 MSTYTTERQEYYLKLEKL 195 Ogataea parapolymorpha DL-1
CAY68792     164 IREYRAKRKLYHLRKEKy 181 Komagataella phaffii GS115
CCE40239     166 LESFKQSRKTYHFKKEKL 183 Candida parapsilosis
XP_002548307 173 IENFKNSRKLYHFRKEKL 190 Candida tropicalis MYA-3404
EMG46218     171 IENFKNSRKLYHYRKEKL 188 Candida maltosa Xu316
Q6BSN3       156 IKDFRSSRKTYHLRKEKL 173 Debaryomyces hansenii
EGV65816     175 LESFKKSRKKYHLRSEKM 192 Yamadazyma tenuis ATCC 10573
EEQ40127     151 LSEFKQKRKEYHLRKEKL 168 Clavispora lusitaniae ATCC 42720
XP_011273040 174 IKNYKAERKLYYLRTEKL 191 Wickerhamomyces ciferrii
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