4ZGQ


Conserved Protein Domain Family
D123

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pfam07065: D123 
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D123
This family contains a number of eukaryotic D123 proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate. D123 proteins are regulators of eIF2, the central regulator of translational initiation.
Statistics
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PSSM-Id: 399803
View PSSM: pfam07065
Aligned: 119 rows
Threshold Bit Score: 249.768
Threshold Setting Gi: 586745569
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ZGQ_A        37 WYSLFRKLTPKAKVIkPIPATVLKYLHEDS-IYVEQPM----------------NTVEEVDSEEDEESAPayy------- 92  fission yeast
1_pfamImport   1 WYHKLKHVAIKSVIV-PLPSDFVSLLLADG-VTLPPAPv--------------sSKVDEVEDDEDSDSGTsltdd--qqr 62 
2_pfamImport   1 WYPLFREHTIKSIVI-SIPEDFVKYLQEDGtVVLPRGAelsgar-----geneeESGEEWENEEEEENLpd--------- 65 
Q5BKN5        14 WYPRFKKLSIRSVVI-PLPENVKDYLLDDG-TLVVSGReespgcsq-rdlnstaEDEVQWSDDENTATLKap-------- 82  tropical clawed...
Q8CII2        14 WYPLFRSLTIKSVIL-PLPQNVKDYLLDDG-TLVVSGRedpptcs--qsdsgneAEETQWSDDESTATLTap-------- 81  house mouse
XP_003455746  14 WYPIFKKHTIKSLIL-PLPQNVIDYLLDDG-TLVVSGSdhntqqtqtnnsdsdaEEDIQWSDDETTTTVTap-------- 83  Nile tilapia
EFX74256      14 WYPLFKKVTFPSKII-PLTQEFVDYLLADN-LVLRSDQallty-------srddSNSSDSEDDEEGWAKAesetpaleap 84  common water flea
XP_011263882  14 WYPTFKKDSLEATIL-DIPDNVLKYLEHDA-FMMPIEAvrslaen---sewtdgSPVTSEEEETDYQpt----------- 77  Florida carpent...
XP_022527519  14 WYPLFKKHTIKSLIL-PLPQNVIDYLLDDG-TLVVSGGcennn-------qcsqNNNSDSEEEEDIQWSDdetttvatap 84  Mexican tetra
ETL46624      20 WYPQLKRVCIKGEVV-PLPTEFVSLLLADG-VTLPSAPv--------------aSGIVDEDDDEEVDAASaltdd--qla 81  Phytophthora pa...
4ZGQ_A        93 peREAIQLIEKAIKELGGAVVPKLNWSTPKDALWITTTGSLKCTTAEEVLLLLKSSDFVAHDLNHAFDDCkdfDNADGS- 171 fission yeast
1_pfamImport  63 aiATVRERVGHVLDAFGGKVFVKTNWSAPRDAAWML--GTLKCTSFDDVFLLLQASDFIVHDLTEPYAGC-----PLDS- 134
2_pfamImport  66 -fPEFLSQINQAIDNLRGKVFPKLGWSSPKDAAWIA-NNSLMCNTAGEVILLLKSSDFIVYDLTSVFKLC-----SDSI- 137
Q5BKN5        83 efPEFSIKVQEAINSLGGSVFPKLNWSSPRDAYWIALNSSLKCQTLSDIFLLFKSSDFVTHDFTQPFIYC-----ADDS- 156 tropical clawed...
Q8CII2        82 efPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITHDFTQPFIHC-----TDDS- 155 house mouse
XP_003455746  84 efPEFTSKVLEAINNLGGRVFPKLNWSAPRDANWIALNSSLQCRSLSDIFLLFKSSDFITHDLTQPFLQC----SDQDS- 158 Nile tilapia
EFX74256      85 hfEDIDKEITTAIAEFGGKAFIKLNWSSPKDAAWIALNNSLQCHMSADVHLLLKSSDFILHDLTEPFKEC----EDQNV- 159 common water flea
XP_011263882  78 -fPEFSKKIQDVLDEY-DAIFIKTNWSSPADATWVAPTKTLKCKTLEEVYLLLKSSDRIAKDLn--------tIKSLRD- 146 Florida carpent...
XP_022527519  85 efPEFTSKVQEAINALGGCVFPKLNWSAPRDANWIALNSSLQCQSLSDIFLLFKSSDFITHDLTQPFLQC-----SDDS- 158 Mexican tetra
ETL46624      82 viSSVKRKVEKVLQDFGGKLFPKTNWSAPRDAAWML--GSLKCTNFEDIFLLLQASDFVVHDLTQPYIGC-----SGENt 154 Phytophthora pa...
4ZGQ_A       172 VPKD-----FSFELVLKEWFPMHASTEFRCFVKSKRLIAFCQRDD-NYYEFLKENIDCYEKLISDLLKk---LDT----- 237 fission yeast
1_pfamImport 135 HIEQeslnrSKCYLVLKKWCNLLDSMLFRCFVVGHRLVAVSQRNCnEFFAFLVEQQDALCGLLHEFYKtn-fRTHkgrse 213
2_pfamImport 138 AGEP-----IPHQLVLRKWANLVPGMEFRCFVWNKSLLGISQRDYkQHYEYIINDKDNLSEEIQNFVYdv-iIDK----- 206
Q5BKN5       157 PDPN-----IKYELVLRKWCELIPGAEFRCFVKENNLIGISQRDYtQYYDHISKQKEEIRKSIQYFFQeh-iQYN----- 225 tropical clawed...
Q8CII2       156 PDPC-----IEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYtQYYDHISKQKEEICRCIQDFFKeh-lQYK----- 224 house mouse
XP_003455746 159 PDPV-----INYELVLRKWSELIPGGEFRCFVKENKLIAISQRDYtQYYQHILKQEEQISQAIQDFFSqh-iQYN----- 227 Nile tilapia
EFX74256     160 NQTP-----VKYNLVLRKWVEINPVNEFRCFVQNKNLIGISQRDDtQFSPFIEKEKEDIVRDIVSFFKeq-iRPK----- 228 common water flea
XP_011263882 147 CENP-----LSFCLVLKQWRDINPCTEFRCFVMDNELIAISQRDIsQYHSSNESEKYSIQTDIKSLFSer-iKGR----- 215 Florida carpent...
XP_022527519 159 PDPA-----INYELVLRKWSELIPGGEFRCFVKENKLIGISQRDYtQHYHHISKQEANISSSILQFFRdh-iQHQ----- 227 Mexican tetra
ETL46624     155 ENSP-----TESYLVLKKWCNFLDSMLFRCFVVGRRLVAVSQRNCdEFYEFLPDQQDELCELLYEFYKknfrKAEge--- 226 Phytophthora pa...
4ZGQ_A       238 --FPDPDFVFDVYIHKD-RAWLIDINPFYP-RTDGLLFSWSE--LE------------SMNSENMKPEIRLIpKGSMPst 299 fission yeast
1_pfamImport 214 fvFPDPDYSFDVYIDKRrRVYLLDINVFGS-VTDTLLFSWTD--LMefqrde-parpqDIDDEQHTIDFRVVeSEQGIr- 288
2_pfamImport 207 --FPNDSFTVDLYKKRDgRFWIIDFNPFGE-MTESLLFTWAE--LSsgdlsdfnssvsILDSDVTIGQFRYTpYDVTMq- 280
Q5BKN5       226 --FPDEDFVFDVYKDSQgKIWLIDFNPFGE-VTDSLLFTWDE--LRrswn-----lsdVENEEQDCPTFRYTnSEVTVq- 294 tropical clawed...
Q8CII2       225 --FLDEDFVFDIYRDSRgKVWLIDFNPFGE-VTDSLLFTWEE--LTsennlr-gevteGDAQEQDSPAFRCTnSEVTVq- 297 house mouse
XP_003455746 228 --FLDEDFVFDVYRDSQgRVWLIDLNPFGE-VTDSLLFTWGE--LTs----------gEVAEQQEGPAFRYTtSEVTVq- 291 Nile tilapia
EFX74256     229 --FHLDNYVMDVFRQRKdKIVLIDFNPYGV-ITDSLLFDWNEdlLQisdts---ettsPSDCASATPDFRFIpEESGIr- 301 common water flea
XP_011263882 216 --FPLCSYSFDVVRRKKdKVKIIDFGPMNAsSTKGTLFTYEE--LQ--------------NHINDTPEFRFIgEEIGIq- 276 Florida carpent...
XP_022527519 228 --FPDeDFvldvyrdcmgrvw-lidfnpfgevtdSLLFSWEE--LTsgns----lttsDTEALQDGPAFRYTtSEVTVq- 297 Mexican tetra
ETL46624     227 flFPDPNYSFDVYVDKRhRVYLLDINVFGA-VTDTLLFSWEE--LLefqtes-patpqDTEDEHHVVDFRVVeSKKGIr- 301 Phytophthora pa...
4ZGQ_A       300 gsAKYYTNRVPFDMIAAS 317 fission yeast
1_pfamImport 289 -aNPLSGYRAPTDLVH-- 303
2_pfamImport 281 -pSENLRYRVPQDFVDLS 297
Q5BKN5       295 -pSPFLSYRLPKDFVDLS 311 tropical clawed frog
Q8CII2       298 -pSPYLSFGLPKDFVDLS 314 house mouse
XP_003455746 292 -pSPCLSYRIPRDFVDLS 308 Nile tilapia
EFX74256     302 -sNPLRRYCVPEDIAHLT 318 common water flea
XP_011263882 277 -pKPPTHFCIPQEISEFF 293 Florida carpenter ant
XP_022527519 298 -pSPCLSYRIPRDFLDLT 314 Mexican tetra
ETL46624     302 -aNPLSGYRAPTDLVDHl 318 Phytophthora parasitica
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