Conserved Protein Domain Family
POP1
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pfam06978: POP1 
Ribonucleases P/MRP protein subunit POP1
This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.
Links
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Statistics
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PSSM-Id: 399753
View PSSM: pfam06978
Aligned: 73 rows
Threshold Bit Score: 113.136
Threshold Setting Gi: 523778059
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCE66155       57 FVNTRAFEIKQLYSSMHQS-RRSNATRVFQSLPRKLRRRTASHNIARIPKRMRNRAKRE--------------------- 114  Tetrapisispor...
EPE04517       56 FLSSLEQEVGDLHSAIKHS-RDARVEKAFQRIPRSMRRRTASHNARRLPRRLRKQAHRD--------------------- 113  Ophiostoma pi...
ERS98367       33 FISALEQEIGDLHSTIKHR-RDDRVEKAYQRVPRDMRRRTASHNARRVPRRLRQQARRA--------------------- 90   Sporothrix sc...
EMR11464       52 LVNSRKFEIRSLFEAMRCS-RQLSAQRAFQSLPRFLRRRSASHDFKRVPKYLRIRAKNE--------------------- 109  Pneumocystis ...
KJE94664       64 FAAARAREIQTMLHALNEPvNGGGGRRVFQTLPRHMRRRAMSHNVKRVPKRSRSAAQREteaiarggggqqannagdgls 143  Capsaspora ow...
Q5CUH4         30 LSSGRKDEICRYVNFIKKS---NSTKRCFQRLPPAIRRRSMSYNVYRAPRKIRPTLFYE--------------------- 85   Cryptosporidi...
EEA07190       34 LVQGREKEICKFLSFVQET---HSIKRSFQRLPPNLRRRAMSYNPYRAPQRIRARLIYE--------------------- 89   Cryptosporidi...
Q9UTA4         43 FIESRSFEITALQDAMKRS-KESSAQRAFQALPRCLRRRAASHNIKRIPKGLRDRALYE--------------------- 100  Schizosacchar...
XP_002175674   43 FLSARSFEIRAFQDAMKRS-KDSSSQRAFQSLPRCLRRRAASHNVRRIPKALRQRALYE--------------------- 100  Schizosacchar...
Q6C480         52 FVNARQREIEKLATAMQSS-RTAASQRSFQSLPRSLRRRAASHDVKRIPKRLRARARQE--------------------- 109  Yarrowia lipo...

CCE66155      115 -------MNKNNnnnekvnnisgGLTIAAKKRSKks---lNA------KQFYRAKMSIKLLRL---------FTKTKNL- 168  Tetrapisispor...
EPE04517      114 -------QAADN-----------TPSIATGLAKRkktrpaSAwvyentKKRIKLQEEKKLAAQgmg-------------- 161  Ophiostoma pi...
ERS98367       91 -------HAADN-----------TPTVASGLAKRkkawpaSAwvhentKKRIKLQQEKKLARGagggg------------ 140  Sporothrix sc...
EMR11464      110 -------MKNKN-----------T-------LKKkg---iKG------KKRMRLLTVHKLKKF---------GVRNVSV- 145  Pneumocystis ...
KJE94664      144 akglpvaMAAES-----------ATTVRVDKIQRetgrsvSKr----aRKRIYARIRRTIQAV---------KRPTRMR- 198  Capsaspora ow...
Q5CUH4         86 -------MAK-------------APPRISRKRRKerkklpWI------RRNLLLRAINRENFC----------------- 122  Cryptosporidi...
EEA07190       90 -------MKK-------------APPKPSRRAKKdrrrifTF------SEKYKMRNRNHNLRL----------------- 126  Cryptosporidi...
Q9UTA4        101 -------MQLSS-----------SSTLPIAPSRQrl---kRF------IKRLRRKLAK--------------SGETKAI- 138  Schizosacchar...
XP_002175674  101 -------MSLQS-----------STTKAIEPSRLrf---kRY------VRRLQKRISA--------------AGKSKQI- 138  Schizosacchar...
Q6C480        110 -------MANDD-----------PSCHTRAATGK--------------NKIGKLRGHKRLLAIldqrkhvvgDRQKNATp 157  Yarrowia lipo...

CCE66155      169 KMLSGPkeltlrnittrqkikhfkdilknklpsS-----STAIACNNQMGSYDNTAVDSL-ATK-TYSRIKYLKRQ---- 237  Tetrapisispor...
EPE04517      162 -------------------------------------edDEEMDVDDVGTDDDAEGGASLtAVPrTPLPIKNLR------ 198  Ophiostoma pi...
ERS98367      141 -----------------------------gddvNdvveeEEEGGAEEDGAEHDKDEAAVM-ACPhPPIAIKNLR------ 184  Sporothrix sc...
EMR11464      146 SEESKD---------------------------------------------ELDESKDDF-LKV-KKVKGKFYKRQ---- 174  Pneumocystis ...
KJE94664      199 RRIAA------------------------------------------------------------NARHRHLLKRA---- 214  Capsaspora ow...
Q5CUH4        123 --------------------------------------------------GKEILPFNIR-NSSdLSTAFRKKGQRstkl 151  Cryptosporidi...
EEA07190      127 --------------------------------------------------DIDRIPEVVNlANYnTTDNAKYSKHWdint 156  Cryptosporidi...
Q9UTA4        139 DSTGSL----------------------------------------VTDNSTDDSRIPSL-AAV-KLIRGKFAGRQ---- 172  Schizosacchar...
XP_002175674  139 VSAGTL----------------------------------------QTKHTTEDSRIPSL-PLV-RLVKGQFAQRQ---- 172  Schizosacchar...
Q6C480        158 MALLQP---------------------------------------------KDVTGKDQT-ATP-PVGKLRFEHRQ---- 186  Yarrowia lipo...

CCE66155      238 --KHFKWLSTHIWHAKRSHLIKR---WGYQIPYSPTQKCYKLTHRigssVASSDGNLL--QDTSFIGNMIIQNE 304  Tetrapisispora phaf...
EPE04517      199 -------LPTHRWHAKRAQMDNPgylWNSTIVRTSANKTYRMTLR----ASGLRPAMCvsWDTSYKATIYLRGT 261  Ophiostoma piceae U...
ERS98367      185 -------LPTHRWQAKRAQMDNPgflWNTTLVRTPANKTYRMSLR----AAGLKPGMCtcWDTSYKPTIELRGP 247  Sporothrix schencki...
EMR11464      175 --KDKTWLPTHLWHVKRAKMLTK---WSYSIAKTPTEKSYRPTHK----FANTSGAVA--FDTSYFCTICLWGE 237  Pneumocystis murina...
KJE94664      215 --RAKGWLETHVWHAKRMKMADQ---WGFRLALRSAQRGMRATHR-----ATLHSVTA--HDASYHGIIELAGP 276  Capsaspora owczarza...
Q5CUH4        152 pfNQFKWMESHLYHSKRFKMCDA---FGYKLPICSTSKRNRKIYR-----AFKHEFVV--HDSSYLQLFELNGV 215  Cryptosporidium parvum
EEA07190      157 qiNQYKWLESHMYFSKRFFMFEA---FGYKLALCSTAKRRRKLYR-----QLSHNCIV--HDMSYFHLYELRGE 220  Cryptosporidium mur...
Q9UTA4        173 --LRKVWLPTHLWVCKRAHMINA---WGYAIPEKPTEKSYRPTHR----AAFRKDAIA--FDMSYEPLFCISGP 235  Schizosaccharomyces...
XP_002175674  173 --LRKIWLPTHLWTSKRAHMVNK---WGYAIPQRPTAKSYRPTHR----AAFTEEAIA--FDMSYEPIFAITAP 235  Schizosaccharomyces...
Q6C480        187 --KDKTWLPTHVWHAKRAHFENR---WGFSIPEKPSQKCYRKTHR----GIKHEGATV--WDSSYTATFRIEAT 249  Yarrowia lipolytica
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