1RH7,1RGX


Conserved Protein Domain Family
Resistin

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pfam06954: Resistin 
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Resistin
This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.
Statistics
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PSSM-Id: 399733
View PSSM: pfam06954
Aligned: 32 rows
Threshold Bit Score: 89.644
Threshold Setting Gi: 156386180
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RH7_D         1 CSFESLVDQRIKEALSRQE------PKT--------ISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNG-NTCHC 65  house mouse
EDO41771      26 GEDETALEGTAVEDEEPVSdpeaivSRKwhlwrkgrLHCLSVSSKGNTAACPAGYLVTGCACGYACGSWNPEANgTRCFC 105 starlet sea ane...
XP_016846768  25 CSIDRAIDAKIKAAVDSKvsa-tlaKSQ--------LTCTTIKTSGALAACLHGYTVTGCSCGKACGSWDVRDN-STCHC 94  green anole
XP_008102434  23 CPVEDAIDAKISAAIDSKvs---ilVPE--------LSCTSVSARGADVSCPSDYKATGCACGMACGSWDIRGE-TQCHC 90  green anole
EHB04250      21 CSMDEAIDQKIKEQTSSLile-aleKAD--------LDCRSVTSKGDLATCPAGFAVTSCACGMGCGSWDVRAQ-TTCHC 90  naked mole-rat
2_pfamImport   3 CPVDAAIDQEIQRGTISLile-afnGLR--------LDCQSVTSRGDLATCPAVSPVTGCACGYGCGSWDVRAE-TTCHC 72 
XP_854313     21 CPVDEAIHEKIQDDTSSLile-tirNFG--------LSCQSVTSRGDLATCPAGFAVTACACGSACGSWDVRVE-TTCHC 90  dog
NP_001186158  24 CPVDDAINEKIKDGTSSLfls-gtrSLN--------LECRTVTSRGALATCPGGYSVTSCTCGSACGSWDVRAE-TTCHC 93  rabbit
XP_003803468  22 CPMDEAVNKKLQEHTSSLisg-slsKMS--------LDCQTVTSRGNLATCPAGFTISSCTCGSACGSWDVRAE-TTCHC 91  small-eared galago
XP_007656086  24 WILDTDVIEKIQERVNSLvss-alkDLS--------LVCTSVFTQGALVACPSGYKATACSCGSACGSWDIRSD-TVCHC 93  platypus
1RH7_D        66 Q--C----SVMDWASARCCRM 80  house mouse
EDO41771     106 HkgCmpngQSLDWTLAMCCKV 126 starlet sea anemone
XP_016846768  95 Q--C----ANVDWTAARCCKI 109 green anole
XP_008102434  91 Q--C----ANIDWTSARCCKV 105 green anole
EHB04250      91 Q--C----ARMDWTAVRCCRL 105 naked mole-rat
2_pfamImport  73 Q--C----QGMDWTTA----- 82 
XP_854313     91 Q--C----AGMDWTAARCCRL 105 dog
NP_001186158  94 Q--C----AGMDWTGARCCRI 108 rabbit
XP_003803468  92 Q--C----AGMDWTGARCCRL 106 small-eared galago
XP_007656086  94 Q--C----RGIDWTSARCCQI 108 platypus
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