Conserved Protein Domain Family
GutM

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pfam06923: GutM 
Glucitol operon activator protein (GutM)
This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes.
Statistics
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PSSM-Id: 399718
View PSSM: pfam06923
Aligned: 42 rows
Threshold Bit Score: 90.671
Threshold Setting Gi: 122973596
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003212289    6 IVLCIILIVQYGLSFIQIKYYRKSMDSLIDDy-rG--KQGYhlfsGMERRKV--GPGAIALIIVD-ESYIIQKCHVLGGV 79  Bacillus pumilus
jgi:Toce_1437   7 GIIGLMWILQGIFTYFQIKNLQEKIKQLKKV---G--RVGI----GSAKGKM--TPGNIVLIAAD-KTGKILEAYRMSGM 74  Thermosedimini...
WP_013406765    7 VIIIVAWLLQAVFTFMQMANFRKRMQELRTK---G--TIGV----GKVTKKF--GIGAIVLLVSS-DHKTITAAEEMFGV 74  Halanaerobium ...
Q182A0          5 VILFVAYILNTIFIMKQNKLYFKTLNRAKKK---Gd-IVST----GKKKSYF--SKGSIAIISSD-SDGFIKFGEILKGR 73  Clostridioides...
WP_009289148   10 LLFLAMAIVSKLMALPQIHKLNKQLMEIKRSgpvS--SVGM----AR---HW--RGNRAYVLVTD-LQGNIVCGYQTSGN 77  Anaerostipes
Q8Y9I3          5 LIASLIFIAQTCLGFFQVKYYQHHMNKVANKy-aG--KIGYhlysEMERLKF--RTSAVAILVVN-ENHIVHECQILTGK 78  Listeria monoc...
Q5WCY9          5 LIACCLLLIQSALTAIQVRYYQKSMKALVGKy-kG--EKGYhlfsGQSRRRI--GPGSIVLLVVD-ESYIIQECQCMRGV 78  Bacillus claus...
jgi:Oant_4108   9 LALALLWGFQSLGVWFQMRHYSDVMKGITSKysdG--FVGA----GHVRGRF--GRGVIVLLVVD-RNLVVRRFLQMSGR 79  Ochrobactrum a...
WP_009291053    7 GFLMVTMAAQAALGWFQIKRMYQSMEDLKRSyrhTpyILAI----GSAKSGLtfRPGVIVIVVVN-DSDEIVDYYEMKGR 81  Anaerostipes
WP_013380769    8 LVVFALMALQMVLSLFQIKRYQRELGKLRGT---G--TIGI----GHTKGGL--KAGQILIVSYSrRKDQVVAYRQMKGL 76  Clostridiales
WP_003212289   80 SILSKFKEVPSYEGKHVGAVLDEhhmMKQTLKKRKK 115 Bacillus pumilus
jgi:Toce_1437  75 TVFARFKEIKEMKGLYLQEVPYV---LNDKDEGFKK 107 Thermosediminibacter oceani DSM 16646
WP_013406765   75 TVFARFKEDEKLKGLSFEEVESLe--FKKESKQeav 108 Halanaerobium hydrogeniformans
Q182A0         74 TVMAKFKEIEEIEGLDIYSAEQK---FKDEESIVQA 106 Clostridioides difficile 630
WP_009289148   78 SVFSGFREDRELKETNYLEIIEN---LSQKKKLtrl 110 Anaerostipes
Q8Y9I3         79 TVFAQFKTFTNYHHKELSEILTE---LSSKNKNTIQ 111 Listeria monocytogenes
Q5WCY9         79 SILSTFKEMEEYEGMHLGELLDR---LHTSEKKRks 111 Bacillus clausii KSM-K16
jgi:Oant_4108  80 TVFAKFSRREGFEGMRLSEL--------QDNPTIGE 107 Ochrobactrum anthropi ATCC 49188
WP_009291053   82 TVFSKFVQKNDYIGCSVNTAGTF---MKRKNEKAAf 114 Anaerostipes
WP_013380769   77 TIFAGFKTNEAILGKSLSDLKDIg--LKEDarefrr 110 Clostridiales
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