Conserved Protein Domain Family
TPX2

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pfam06886: TPX2 
Targeting protein for Xklp2 (TPX2)
This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way.
Statistics
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PSSM-Id: 399698
View PSSM: pfam06886
Aligned: 89 rows
Threshold Bit Score: 32.5487
Threshold Setting Gi: 164636822
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q84JG6        401 FVFRSDERAEKRKEFFKKVEEKNKKEKEDKFSCGFKANQntNLASEEHKNPQVGGFQVTPMtltsPRFRRNQ-TPGKEni 479  thale cress
XP_011619075  585 FELSTERRARDRQEYERTAMEKEAIRAMMEEEHKREEEQ--REKEEIARLRQEQVHKAQPV----KHYKPVSlKKSEV-- 656  torafugu
XP_015220521  618 FQLSTERRAKERMEFDHIVAEKERQRALKEEEERREQEE--KAKEEISRLRQEQVHKAQPV----RRYKPLElKKSEV-- 689  spotted gar
XP_022532559  648 FQLSTERRAKERLEFERALKEKEALRAQVEEQESRDREE--HEKEEIIRLRQEQVHKAQPI----RRYKPVElKHSEA-- 719  Mexican tetra
NP_001314674  636 FQLATERRAKERLEFEKELSEREALRARMEEERAREREQ--QEKEEIARLRQEQVCKAQPI----RHYKPVElKKSDV-- 707  zebrafish
XP_002594065  729 FDLNTVRRAEQRQEFEMQKKMKEEEMEALRQQQEAERRE--QEQVEIARLRKELVHKANPI----RHGRPLEiQPSNK-- 800  Florida lancelet
EDO36718      135 VVLNSDKRAQERAIYEMQKHEKEMEEEAILRQREEEREE--EERRNIAMLRQQMVHKANPI----ARFKGVQiLPSEK-- 206  starlet sea a...
EFX86820      493 FSLTTVKRAAERKNFDQFLKEREQEKEMHKLRREQEKLQ--KESEQAARLREETVFFANPI----RHFKTVEiKKADA-- 564  common water ...
OWR53665      642 FDLTTTKRAAERELFEKQLKEKEEENERLRLQKEREKQE--AEERAIAELRAKLVHHAKPV----PALHPFIpGKSDA-- 713  Danaus plexip...
XP_004932479  380 FELTTEKRAAEREKFEKQLREKEEEMERIKQMKEKERLE--SEERAKAELRAKLIHHAKPV----PVLVPFVpEKSAA-- 451  domestic silk...
Q84JG6        480 kkPhQTPHKASS 491  thale cress
XP_011619075  657 --P-LTVPQSPN 665  torafugu
XP_015220521  690 --S-LTVPQSPN 698  spotted gar
XP_022532559  720 --T-LTVPQSPK 728  Mexican tetra
NP_001314674  708 --S-LTVPQSPN 716  zebrafish
XP_002594065  801 --P-LTNPQTPN 809  Florida lancelet
EDO36718      207 --P-LTEAHSPA 215  starlet sea anemone
EFX86820      565 --EiLTVPKTPK 574  common water flea
OWR53665      714 --P-ITVPETPK 722  Danaus plexippus plexippus
XP_004932479  452 --S-LTVPETPK 460  domestic silkworm
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