Conserved Protein Domain Family
Elongin_A

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pfam06881: Elongin_A 
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Statistics
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PSSM-Id: 399694
View PSSM: pfam06881
Aligned: 106 rows
Threshold Bit Score: 76.0952
Threshold Setting Gi: 328871862
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG12725             20 LKDVGNCVYELIRPVLFACPPDQLAEIEDLSPHLMLE---SDEIWLLHL------RRDFPNESK-PQATRtiepepnsep 89  Melampso...
KDE06957             62 ITDIGDCSYDLIKNILALFPAEQLHLIETRSPHISEH---TGPLWKKLC------VKDFVNIriqvedg----------- 121 Microbot...
XP_013025656         19 IEDIGDYPYALLEPILERAPPDRLHLLEERSPHIKQE---SQSLWKLHV------LRDFALELQqFKAPLps-------- 81  Schizosa...
WGS:AATM:SJAG_00540  21 IEDLGDHPFSLVEPILACARPDHLIRLEQNSPHLRDD---TQGLWKVHV------YREFGLDITdQDTSNi--------- 82  Schizosa...
O59671               19 IDDIGDCPFELVKPILEKARPEHLIDLEEKSPHLKVD---TQPLWKDHV------LRDFGLELQ-KRTILnn-------- 80  Schizosa...
Q55CM9               30 CKDLGKIPDELLIPILDKCTAQQLATVESRI----GRyvdTEELWKRHChiispeKRHTLKDDE---------------- 89  Dictyost...
Q5KCI4              116 iWDIGDLEYSLVKPFIDEVPMEQLAEIEANSPHIKKD---TDWLYELFM------LQDYRLFHE-RCRERqg-------- 177 Cryptoco...
SAM84005             92 VQDLGEMPYRNAKPILEECRVEQLVTLEEASPHLLEH---TEEVWKRNC------LRDFNELRK-KYTpstp-------- 153 Ustilago...
CBQ68825             70 VQDLGVLPYRHAKPILEECRVEQLIALEDASPHLLAH---TDEIWRRNC------LRDFLELRR-KYssad--------- 130 Sporisor...
GAC75749             78 VQDLGDMPYRNAAPILEECRIDQLILLEEASPHLLGH---TDEIWKRNC------LRDFFELRK-KYSepia-------- 139 Moesziom...
EGG12725             90 yptqtinpyTnepidlpIHRIQYFTIKQSKAKALANASARLRERTQANRSEFSKRKA 146 Melampsora larici-populina 98AG31
KDE06957            122 ----------tmkhepaSWRDLHVEETKRRDAKMEAVQARMRTQYKGYSEGRATtnv 168 Microbotryum lychnidis-dioicae ...
XP_013025656         82 --------iT-------DWRSLYQRLKKRRNTQYNEASEKLRNAYTKLEQTKQTKRi 123 Schizosaccharomyces cryophilus ...
WGS:AATM:SJAG_00540  83 ---------Q-------DWRRAYEDFKKRRNAQYNLASKKLRSAYTKLEQNKQHKRI 123 Schizosaccharomyces japonicus y...
O59671               81 --------iD-------DWRGLYGKLKKKRNAHYNVASAKLRSAYTKLEQSKQNKRi 122 Schizosaccharomyces pombe 972h-
Q55CM9               90 -----------------SWRDLFTILEREYQNKTKKTGEALRKIYNNAANNKKSKQI 129 Dictyostelium discoideum AX4
Q5KCI4              178 --------ePrt----tGWRKMYKKAKEDAAERQLQAADRVAARYKQLEEEKKSKSI 222 Cryptococcus neoformans
SAM84005            154 -----cialPke---pkSWRRLYFRTKGETEQAKLEAAKRIKDKYVQHRAEKEAKKL 202 Ustilago bromivora
CBQ68825            131 ------avvPke---prSWRKLYLRTRGEIEQAKTDAAKRIKHKYEQHRAEKDAKKL 178 Sporisorium reilianum SRZ2
GAC75749            140 -----gaaaPre---pkSWRKLYFRTKGEIEQAKVEAAQRIKDKYAQHRAEKDAKKL 188 Moesziomyces antarcticus T-34
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