6H67


Conserved Protein Domain Family
RNA_pol_I_A49

?
pfam06870: RNA_pol_I_A49 
Click on image for an interactive view with Cn3D
A49-like RNA polymerase I associated factor
Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures. Deletion analysis of the fusion yeast homolog indicate that only the C-terminal two thirds are required for function. Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA.
Statistics
?
PSSM-Id: 399688
View PSSM: pfam06870
Aligned: 106 rows
Threshold Bit Score: 203.609
Threshold Setting Gi: 308454554
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6H67_M        33 PSDTTFDLYK------KKksEKDEFVLHGEN-ERLEYEGYTDSSSQASN----------------QYVVGLFNPEKKSIQ 89  Saccharomyces c...
EGT52755      43 lDKLVFERHGki---gPK--KAPIFTVNEAIsERVVEVGTEVNCIEDGF----------------DFVVAIVDNETGNAN 101 Caenorhabditis ...
Q95X83        43 LKNLTFERHGkg---gRK--KAPIFSVKGDIsEHVVEVGADVNCLDEGF----------------DFAVALVDKRTGEAT 101 Caenorhabditis ...
2_pfamImport   1 LQNLKFERHGka---gRK--KAPIMSVKGEIcEKVMEIGTDVNCLDEGF----------------DFAVAVVDTETGEAT 59 
XP_005061362  87 PDSLRFTVYRsqdtahPR--KKHRRILVSET-ERLCYVGHNFGSEVMKCns------------lcRYFVGVLDKNSGQME 151 Collared flycat...
XP_007498064  32 SENVNFSLYKskdttnPR--KKFRRILAAET-DRLSYVGNNFGTGALKCnn------------lcRYFVGVLNKNSGQME 96  gray short-tail...
EGV92192      51 PGNMRFTLYNsndlvnPR--LKNQRILAAET-DRLSYVGNNFGTGALKCnt------------lcRHFVGILNKTSGKGE 115 Chinese hamster
XP_004048088  36 PGNMRFTLYEnkdstnPR--KRNQRILAAET-DRLSYVGNNFGTGALKCnt------------lcRHFVGILNKTSGQME 100 western lowland...
ELK12997      36 PGNIRFTLYKsndstnPR--KRSQRILVSAA--------------VARCstlqalgdpltggcgrEHFVGILNKTSGQME 99  black flying fox
KAE8632284    32 PESVNFTLYSnkddnnPK--AKRQRILAAET-DRLSYVANNFTSDAVKSns------------lcRYFVGVLNKETGKME 96  tropical clawed...
6H67_M        90 LYKAPVLVSKVVS--------KSSKN--LRGPKI--------KSkSDTRpsaLRNALGEAFGTKKAKKAIADLERNRIDS 151 Saccharomyces c...
EGT52755     102 YHPARLYSFESKCtedfekllNDRKS--LADNFEadf---siGAeKWAE---KRRQLTSNFGSSKKIKMDVAAQRRTINQ 173 Caenorhabditis ...
Q95X83       102 YRPARFYSFESKFsedi-ekifSDKK--ESSSEEyknd-fsiGAeKWAE---KRRQLTSNFGSSKKIKMDEAAQRRTINQ 174 Caenorhabditis ...
2_pfamImport  60 YRPARFYSFESKYaedlekliGTNKK--DTKNAEdyaedfsiGSdKWAE---KRRQLTSNFGSSKKIKMDEAAQRRTINQ 134
XP_005061362 152 VYNAEIFNMQPLL--------SDNPL--PDDTKd-------yQTkSYRE---KMDLCIEAFGTSKQKRALSSRRMNAVGT 211 Collared flycat...
XP_007498064  97 IYDAELFNMQPVF--------SDDLK--DSETTLg------nQTkSYRD---QVDFCIEAFGTTKQKRALSSRRMNKVGS 157 gray short-tail...
EGV92192     116 VYDAELFNMQPLF--------AEDAI--EQEPPPe------nQAkTFRE---KLDSCIEAFGSTKQKRSLNSRRMNKVGS 176 Chinese hamster
XP_004048088 101 VYDAELFNMQPLF--------SDVSV--ESELALe------sQTkTYRE---KMDSCIEAFGTTKQKRALNTRRMNRVGN 161 western lowland...
ELK12997     100 VYDAELFNMQPLF--------SDDSV--ESESSLe------sQVkTFRE---KMDSCIEAFGTTKQKRALNSRRMNKVGS 160 black flying fox
KAE8632284    97 VYDSEQYRMQPIL--------ESNKEkeLHTEDVmd-----qPSkSYRE---KVDALIESFGTNKQKRALSSRKLNQVGS 160 tropical clawed...
6H67_M       152 DKLTDSAIDIVDSVRTASKD---LPTRA----QLDEITS-NDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILK 223 Saccharomyces c...
EGT52755     174 ETLDEMRKTAFASKSNIKKEd-hEEFKLeditMMNKAAS---SILPPA-VQTELSRDIYPISLFLEELEIDAIESIATEL 248 Caenorhabditis ...
Q95X83       175 ETLDEMRKTAFASNSNVKTEdgaADVKLenitMMNKAES---SILPPA-VQTELSRDIYPISLFLEDIEIDAIESIATEL 250 Caenorhabditis ...
2_pfamImport 135 ETLDEMRKTAFASNSNVKTEe-qGDVKLenitMMNKATS---SILPAA-VQTELSRDIYPISLFLEDVEVEAVKSLAEEV 209
XP_005061362 212 DIVSTAVTKAAANVIDAKGVt--ALVQDvaqdDVQNIS----AFLPPCHEDADSPEHVYKFEDILSPAEYEALRVPAAAL 285 Collared flycat...
XP_007498064 158 ETLNIAVAKAAENIIDEKGVt--ALLNDaaqnDLQDES----AYLPPCHTDGVKPEEIYKFEDLISPEEYKALQDPSEVL 231 gray short-tail...
EGV92192     177 ESLNLTVTKAAENIIDTKGVn--ALVSDamqdDLQDDS----LYLPPCHADATKPEDVYRFEDILSQAEYDALESPSEAF 250 Chinese hamster
XP_004048088 162 ESLNRAVAKAAETIIDTKGVt--ALVSD----AIHNDLQdDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAF 235 western lowland...
ELK12997     161 ESLNHAVAKAAENIIDTKGVt--ALVSDaihdDLQDDS----LFLPPCHADAAKPEDVYEFEDLLSSAEYEALQSPSEAF 234 black flying fox
KAE8632284   161 EILNKAMAKAAEEIIESRGTk--ELVKDavdkKQQETS----LFLPPCDYNANKPENAYKFDDLISPVEYAALETASAAF 234 tropical clawed...
6H67_M       224 EA-DKEKKLELFPYqNNSKYVAKKLDSLTQPSQ-----MTKLQLLYYLSLLLGVYENRR-VNNktkllerlNSPPEILVD 296 Saccharomyces c...
EGT52755     249 MDkKKKEKIEA--------GIPECVVLIMHNEKtkeraAAYLLLATMIEILMKMGKHRQmFLKem----ndMKMPDILRQ 316 Caenorhabditis ...
Q95X83       251 MEkKKKEKLEA--------GIPECVTLIMYNEKtkqraAAYLLLSTMIEILTKMGKQRQlLRKdl----seLKMPDILRQ 318 Caenorhabditis ...
2_pfamImport 210 MEkKKKQRVED--------GVPECVALIMYNEKveqraVAYLLLATMVEILAKMGRTRQvLRKel----neLKMPDVLRQ 277
XP_005061362 286 ASiTTEELAKKAEErSHCSFVLEELKFLPT--Dek-srDHKARCLWFLDTLIKFSRLKViKKKhp----mgPECPHIISR 358 Collared flycat...
XP_007498064 232 KNvTSEEILKMIEEkSYCPFVIEALKSLPL--Nee-srDHKARCLWFLNILIKFRSQSViKKKns----lgPEVPHIINT 304 gray short-tail...
EGV92192     251 RKvTSEDILKMIEEnRHCSFVIEMLKSLPS--Nee-srDRQARSIWFLDALIRFRAQKViKGKsa----lgPGIPHIINT 323 Chinese hamster
XP_004048088 236 RNvTSEEILKMIEEnSHCTFVIEALKSLPSDVEs---rDRQARCIWFLDTLIKFRAHRVvKRKsa----lgPGVPHIINT 308 western lowland...
ELK12997     235 RNvTSEEILKMIEEnSHCSFVIEALKSLPS--Nee-srDHQARCIWFLDTLIRFRAQKViKRKsa----lgPGVPHIINT 307 black flying fox
KAE8632284   235 RNmTSEDLLQMVENkKSGLFVLQELQGLREIKDek-alDHQARCLWYLDALIKLSQLRTvKRKdi----mtPECPGIICG 309 tropical clawed...
6H67_M       297 GILSRFTVIKPGQFGRSKDrs--yfIDPQNEDKILCYILAIIMHLDNFI-VEITPLAHELNLKPSKVVSLFRVLGAIVKG 373 Saccharomyces c...
EGT52755     317 KVHAQFFNDTTSEKGYSGRsaerirLNVTDYDRLVAHTLALALTLAPEHkVPLTPFQQALAYQPSKLEKLFQALGADLIR 396 Caenorhabditis ...
Q95X83       319 KVQAQFFNDSTNEKGYTGRgaerirLNVTDYDRFIAHTLALALTLAPEHkVPITPFQQALSYQPSKLEKMFQALGADLIR 398 Caenorhabditis ...
2_pfamImport 278 KVLAQFFNESISEKNYAGRgaervrLNVTDYDRFVAHTLALALTLAPEHkVPITPFQQAFGYQPSKLEKMFQALGADLIR 357
XP_005061362 359 KLMKNFSSLTYNDGSIQNL------ISASMKAKITAYVIALALHINNFQ-TDLTVLQNDMKLSETRILDIAKALRLRVSK 431 Collared flycat...
XP_007498064 305 KLLKNFTSLTYNNGSLRNL------ISDSMKAKITAYVIALALHIDDFQ-TDLTMLQRDMKLSEKRIIEIAKAMRLKISK 377 gray short-tail...
EGV92192     324 KLLKNFTCLTYNNGSLRNL------ISSSMKAKITAFAIILALHINSFQ-IDLTLLQGDLKLSEKRMIEIAKAMRLKISK 396 Chinese hamster
XP_004048088 309 KLLKHFTCLTYNNGRLRNL------ISDSMKAKITAYVIILALHIHDFQ-IDLTVLQRDLKLSEKRMMEIAKAMRLKISK 381 western lowland...
ELK12997     308 KLLKHFTCLTYNNGSLRNI------ISNSMKAKITAYVIILALHINDFQ-IDLTVLQRDLKLSEKRMIEIAKAMRLKISK 380 black flying fox
KAE8632284   310 KLMKNFTVEVFKNGRIQNS------ISGTTKTKIVAYVIAIALHISDFQ-VDLTLLQRDMKLQESRILEIAKAMGLKIAK 382 tropical clawed...
6H67_M       374 ATVAQAEAFGIpkstaaSYKI---ATMKVPFKLPEMTRRGR 411 Saccharomyces cerevisiae S288C
EGT52755     397 LDIASAQNL----------RSlraAILLKP---PSSEQKGH 424 Caenorhabditis brenneri
Q95X83       399 LDVASAQTL----------RSlraAILLKP---PSLEQKGP 426 Caenorhabditis elegans
2_pfamImport 358 LDVQSAQNL----------RSlraAILLKP---PSLEQRGP 385
XP_005061362 432 AKGGPGLEDEH------NHKL---GTLSLPLPSQKAPEGQR 463 Collared flycatcher
XP_007498064 378 KKLSLESGGEE------HHKI---GTLSIPLPALPLRKrr- 408 gray short-tailed opossum
EGV92192     397 RKVTLADGREE------DHRL---GTLSVPLPPPQTSDRQS 428 Chinese hamster
XP_004048088 382 RRVSVAAGSEE------DHKL---GTLSLPLPPAQTSDRla 413 western lowland gorilla
ELK12997     381 RSVSLAAGTEE------EHKL---GTLCIPLPPAQTldrqs 412 black flying fox
KAE8632284   383 RTMYSESLIEE------GHKI---GMLTIPLTVYKPSGGEl 414 tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap