Conserved Protein Domain Family
DctM

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pfam06808: DctM 
Tripartite ATP-independent periplasmic transporter, DctM component
This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.
Statistics
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PSSM-Id: 284275
Aligned: 17 rows
Threshold Bit Score: 236.768
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O29619              128 LAVIFVLEATRRVVNPALVVVAIiFILYAKFGASlpgvl-shpsyDWKqILEHLYYTkegifgtP----IAVSSSFVVL- 201 Archaeog...
Q8ZKS0               12 IAVFVVLLAMGAPIGICIVIASFsTMMLVLPFDI-----------SMF-ATAQKMFS-------S----LDSFALLAVPf 68  Salmonel...
Q9Y8U1              115 LVMFAALLKYRAI----FILNVL--LFIYTLNGSwapypfdhpgiRLErIITAMSVEfe----tGvfekLPQLALTLIGa 184 Aeropyru...
Q2YRV7              148 LLILILLEATRRSVGWPLPIISVlFMLYALYGPSmpgil-vhpgaTVSqLVDHLYLTtqgiygiA----LGVVATYVFH- 221 Brucella...
Q8FRN3              157 FYWVAVLEILRRCAGPIVAGLALaVSIYPMFADIipvgflqgisyDPVtLAQVHVMGtesihglP----LQTAATILVG- 231 Coryneba...
Q89NA6              151 VMWVMLMEALRRTGGWSLLLSVFpFTVYPLFAESgwlgpfrgtqsTLEqATAYHVLSgesllgiP----IQAFADTVIG- 225 Bradyrhi...
Q92WB7                5 VGSFLVLMLVGVPVAISMAAASV--LYLVSYNVA-----------PDI-IAAQRMIA-------G----VESFPLLAVPf 59  Sinorhiz...
Q9CKH6                7 LGTMFLLTVFGLPLFYSIIFASI-VTLFYFLPNI-----------PVT-IVAQQVMQ-------G----LDTNALQALAf 62  Pasteure...
Q8ZL80                7 LCCLLGGIAIGLPIAWSLLLCGA--ALMAYLDMF-----------DVQ-IMAQTLVN-------G----ADSFSLLAIPf 61  Salmonel...
rhodo:RCAP_rcc03022   7 FGLLIALMLTGMPISISLGLTVL--TFLFTMTQV-----------PID-TVALKLFT-------G----IEKFEIMAIPf 61 
O29619              202 FVIFGAFLERSGAGRFFIDLAYSLTGWMVGGPAKAAVVSSALMGTISGSSVANTVTTGAFTIPLMKRVGYKPEFAGAVEP 281 Archaeog...
Q8ZKS0               69 FVLSGVIMNSGGIAARLVNFAKLFTGKLPGSLSYTNIVGNMMFGAISGSAIAASTSIGGVMVPMSAREGYDRGFAAAVNI 148 Salmonel...
Q9Y8U1              185 FMLFISIAQAFGAVDSVIRLVIGALGSRPRLLPQAAVVGSMVIAMVSGSGAANAASTGSITIPLMKKAGMPPVKAAAIET 264 Aeropyru...
Q2YRV7              222 FVLFGVFATRIGLGQLFLDCAAWVAGRFAGGPAKVSIFGSALFGMISGSSVANAVTVGSLTIPAMIRLGYKRHFAAAVES 301 Brucella...
Q8FRN3              232 FMLFGVTLQHTGGAEFFNDLSRAIFGRYRGGSAKVSVASSASMGMMSGSAVSNVLTTGPMTIPAMIRSGFTPKTAGAIEA 311 Coryneba...
Q89NA6              226 FLVFGTALMMTGAGKFFINLAFALCGTFRGGAAKVCIFASGLLGMMSGSIISNVLTAGTMTIPVMKKSGFRASYAGAIEA 305 Bradyrhi...
Q92WB7               60 FILAGNLMNSAGVTGRIYSFAVALVGWMKGGLAQVNIVGSVIFSGMSGTALADAAGIGTIEIKAMKDHGYPVDAAVGVTA 139 Sinorhiz...
Q9CKH6               63 FFLAGELMSVGGITNRIIRFVTSIIGRWKGSLAYINIFSSLFFGSISGSAVASTAAIGSSLIPEMKKRGYPAPFSAALTQ 142 Pasteure...
Q8ZL80               62 FVLAGEIMNAGGLSKRIVDLPMKLVGHKPGGLGYVGVIAAMIMASLSGSAVADTAAVAALLVPMMRSANYPINRSVGLIA 141 Salmonel...
rhodo:RCAP_rcc03022  62 FILAGNFLTHGGVAKRMINFATAMVGHWHGGLGLAGVIACALFAAVSGSSPATVVAIGSVILPAMVNQGFPKQFGAGVIT 141
O29619              282 AASTGGQIMPPIMGAAAFIMAe------------FVGMPYINIVYAAIIPAFLYFFGVFSAVDFEARKENLRG-LSREEL 348 Archaeog...
Q8ZKS0              149 ASAPTGMLIPPTTAFILYALA-------------SGGTSIAALFAGGLVAGVLWGVGCMLVTLVVAKRRNYRV-FFTVQK 214 Salmonel...
Q9Y8U1              265 ASSIGGQLMPPIMGISAFVMAd------------YLGVSYFDVVARGWAPALIYYIGLAAAVYLASK--AFLS-GTAALN 329 Aeropyru...
Q2YRV7              302 ASSTGGQITPPIMGAAAFLMIe------------FLNLPYTTIILAAIVPAFMHFFGVLMQVHFEAKRTGLRG-MTKEEM 368 Brucella...
Q8FRN3              312 TASSGGSITPPIMGTAAFLMVs------------FLGIPYTEIIIAATIPAALYFIGIFLQVDGYAALRNLHG-EDRKLL 378 Coryneba...
Q89NA6              306 CASTGAVLAPPVMGATAFVIAq------------FLNVSYADVAVAAIIPAALYYVGLFMQVDAYAARHGLKG-IPRAEL 372 Bradyrhi...
Q92WB7              140 ASATLGPIFPPSLPFVIYGM--------------MANVSIGALFMAGVVPGVVMTVLMMLTVAIFAYKRGWGS-DTPFEM 204 Sinorhiz...
Q9CKH6              143 SASIIGPIIPPSVPMIVFAALa------------GAGVSVGKMFMSGIIPGLMIALTLILITFIISKIKGYGNhSVEFSL 210 Pasteure...
Q8ZL80              142 SGGIIAPIIPPSIPFIIFGV--------------SSGLSISKLFMAGIAPGIMMGAALMLTWWWQAGRLNLPS-QPKATP 206 Salmonel...
rhodo:RCAP_rcc03022 142 TSGALGILIPPSIVMVMYAVAtsgmvvtgpdgqpVSSASVGELFMAGVVPGLMLAGFLAFTTWNRARKFGYPR-LEKASL 220
O29619              349 PSPLQVLKGGW-------------------------------------------YYLVPLFIIIYMLVSGYTPILAGVYS 385 Archaeog...
Q8ZKS0              215 GMALKVAVEAIp------------------------------------------SLLLIVIIVGGIVQGIFTAIEASAIA 252 Salmonel...
Q9Y8U1              330 IGYGRLEVYKAt------------------------------------------SLMASILLLI-ILMGARREY--PAYA 364 Aeropyru...
Q2YRV7              369 PDLKEALKRDW-------------------------------------------PTIIPLVVLIAVLLSGYTPYLAAFWG 405 Brucella...
Q8FRN3              379 PRVSQALRDGW-------------------------------------------PYVIALGILTGMLLTMPSEAQVPFYI 415 Coryneba...
Q89NA6              373 PRIMDTIKDGW-------------------------------------------YYVFVIALLIVMLLYFKRESHAPFYA 409 Bradyrhi...
Q92WB7              205 KRLLAASLEVVvvlavplfiyllmaaglsmnlavgialvvllaldwyfdfsavmALMTPIILIGGMTMGWFTPTEAAVAA 284 Sinorhiz...
Q9CKH6              211 KEVKESAKDAVw------------------------------------------ALLCPIIILYGIISGIFTATEAGAVS 248 Pasteure...
Q8ZL80              207 REIWQSLVSGIw------------------------------------------ALFLPVIIIGGFRSGLFTPTEAGAVA 244 Salmonel...
rhodo:RCAP_rcc03022 221 RQRWTAFREAAw------------------------------------------GLMLIVVVIGGIYAGIFTPTEAAAMS 258
O29619              386 IYAV--IAIMILKplimnyrkpaEQREPLGKVLKGsilnilsaLEHGGRSA----TTVAMACASAGIIVGVVTLTGLGFK 459 Archaeog...
Q8ZKS0              253 VVYT--LLLTMVF----------YRTLKIKDLPSI--------LLQTVVMT----GVIMFLLATSSAMSFSMSITNIPAA 308 Salmonel...
Q9Y8U1              365 ALQSsiLLLALLaaa------eaSRGKSLHEVAGRil----arLAETLKIFsgfvADITILLAALGVMTGLMTITGIPTR 434 Aeropyru...
Q2YRV7              406 ITLC--IAVGLLNp---------RKRMTIGEVFEG--------LRDGAKYA----LAVGAAAATVGIIVGVVTLTGVGFK 462 Brucella...
Q8FRN3              416 VALL--LGIALVRp---------SVKFGFKELFEM--------MLDAGKSL----GQIIAIIAGVGLILGGLSSTGVALS 472 Coryneba...
Q89NA6              410 TALL--LVLNQLFs--------kDTRWTLATIGKF--------LEVNGRTF----VELVGILAGCGLLIGAFSMTGVVSS 467 Bradyrhi...
Q92WB7              285 VIWS--LFLGLVR----------YRTMTMSTLARA--------TFDTIETT----ASVLFIVTAASIFAWLLTVSQAAQM 340 Sinorhiz...
Q9CKH6              249 VVYA--YLIGTFV----------YKELNLERLKKA--------FISSLKGT----ITVMLIVGASSIFAWMIARLQISHQ 304 Pasteure...
Q8ZL80              245 AFYA--LFVAVVI----------YRELTFSSLYHV--------LVNAAKTT----SVVMFLVAAAQVSAWLITIAELPMM 300 Salmonel...
rhodo:RCAP_rcc03022 259 AVYA--FFISVFV----------YKDLTLRDVPRV--------LLSSANMS----AMLLYIITNAVLFSFLMAHEGIPQA 314
O29619              460 IAAAAIALS---------------------HGylPIILALTMLVSL--ILGMGVPTTANYIITSTIAAPAIITFMAQGyg 516 Archaeog...
Q8ZKS0              309 LSDMILGISa--------------------NK--LVILLVITVFLL--IIGAFMDIGPAILIFTPILLPIMAKLGVDP-- 362 Salmonel...
Q9Y8U1              435 VGFLLLEVGa--------------------GN--K-ILLVMLAFVFgyLVGLGLPPVVTYILTVVVIGPYMLQAGFNP-- 489 Aeropyru...
Q2YRV7              463 ISYIVTSTAaqlatyfgtilpvswfapqtlTL--LFTLVMTGMVCI--LMGCGIPTTANYIIMATIAAPALGLLGVEP-- 536 Brucella...
Q8FRN3              473 LSRDLLMLVg--------------------GNliL-LLIAAALACF--ILGMGLTISAAYVFLAIVMVPAIIAMDVNP-- 527 Coryneba...
Q89NA6              468 LANDLLHIAg--------------------DNpfL-LLGMCALTSL--ILGLGLTTTACYIFLAILVAPALEKLGLNR-- 522 Bradyrhi...
Q92WB7              341 LSGAILTITd--------------------NK--WVFLILVNLLML--FVGCFLDTIAAITILVPILLPLTAQFGIDP-- 394 Sinorhiz...
Q9CKH6              305 VASWVSSVCs--------------------SP--LEALILINVIVL--FIGMIMDPTAALTILVPVFMPIVNQFGISP-- 358 Pasteure...
Q8ZL80              301 VSDLLQPLVd--------------------SP--RLLFIVIMISIM--VVGMVMDLTPTVLILTPVLLPLVKEANIDP-- 354 Salmonel...
rhodo:RCAP_rcc03022 315 LGEWMVNAGl--------------------SW--WMFLIIVNILLL--AAGNFMEPSSIVLIMAPILFPVAVRLGIDP-- 368
O29619              517 mpvrefletypelvLPAHMFVFYFGVAADLTPPVALAAYAGSAIAggdpwktgiNAVKIGIGKYLVPYLFIFSPALLLIG 596 Archaeog...
Q8ZKS0              363 --------------VHFGIIMIYNLAIGTITPPVGSGLYVGASVG---------KVKVEEVIKPLLPFYGAIIGVLLLIT 419 Salmonel...
Q9Y8U1              490 --------------WAVHFYAFLLGVMSELSPPTSVTAAVTSRIA---------GAGFVETMIESIKFAMPLFTVMAGVL 546 Aeropyru...
Q2YRV7              537 --------------IVAHFFVFYYGVLADITPPVALAAYAAAGMAgadpfktgnTAFRLGLGKVLVPFVFVFSPSLLLVT 602 Brucella...
Q8FRN3              528 --------------IAAHLFIIYWASISYITPPVGLAAFAAAGISkaspmatsfEAMRFGAVKYVVPFGFVLNPALVAQD 593 Coryneba...
Q89NA6              523 --------------MAVHMFIFYWGMLSSITPPVAIASFAAAGIAgspamktgwESMWVGSIIYFIPFFFVLNPALVLQG 588 Bradyrhi...
Q92WB7              395 --------------VHFGLIMTLNLMIGLLHPPLGMVLFVLSRVA---------KLSVERTTMAILPWLVPLFIALILIT 451 Sinorhiz...
Q9CKH6              359 --------------IHFGLVVILNLMIGLITPPVGYLIFLSANIA---------ECEPIKVLKESLPFLLSLLGLLILLI 415 Pasteure...
Q8ZL80              355 --------------IYFGVMFIINCSIGLITPPVGNVLNVISGVA---------KLKFDDAVRGVFPYVVVLMSLLVLFI 411 Salmonel...
rhodo:RCAP_rcc03022 369 --------------VHFGIMIVVNMEVGMCHPPVGLNLYVASGIT---------KMGITELTVAVWPWLLTMLAFLVLVT 425
O29619              597 VKTPA 601 Archaeoglobus fulgidus
Q8ZKS0              420 YIPEI 424 Salmonella enterica subsp. enterica serovar Typhimurium
Q9Y8U1              547 LEPGL 551 Aeropyrum pernix
Q2YRV7              603 SNFNW 607 Brucella abortus 2308
Q8FRN3              594 SLPNI 598 Corynebacterium efficiens
Q89NA6              589 SSPYL 593 Bradyrhizobium japonicum
Q92WB7              452 FVPAV 456 Sinorhizobium meliloti
Q9CKH6              416 LVPEF 420 Pasteurella multocida
Q8ZL80              412 FIPEL 416 Salmonella enterica subsp. enterica serovar Typhimurium
rhodo:RCAP_rcc03022 426 YVPAI 430
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