4OHY


Conserved Protein Domain Family
Clp1

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pfam06807: Clp1 
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Pre-mRNA cleavage complex II protein Clp1
This family consists of several pre-mRNA cleavage complex II Clp1 (or HeaB) proteins. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. Clp1 is a subunit of cleavage complex IIA, which is required for cleavage, but not for polyadenylation of pre-mRNA.
Statistics
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PSSM-Id: 399650
View PSSM: pfam06807
Aligned: 126 rows
Threshold Bit Score: 79.0739
Threshold Setting Gi: 1084306156
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OHY_A       316 LYPFTFDVSFDDVTLCKIG---AEQLPDSCLPFG-M----------EVENHE--TKLVIME-PS-----ADIKHHLFAFS 373 Caenorhabditis ...
XP_002617501 338 LSPFKTDVDVKSVVIYKAVrlsEYTSQMAFLPSGdSy---------TQEDTKpdLALDKYYvRIea-tsANLENCVLAIT 407 Clavispora lusi...
XP_004200870 363 LSPFKTDIDIKDYKFFSCFeasELNSNLAFLPSGdSftpeeseaseKEKKDR--FDLDKYYrLLeepnaSNLENCILAIT 440 Pichia farinosa...
EGW31230     350 LSPFKTDIDLHDLVIYKPVvtrDLMSSLSFLPK--------------------------YYaILeepssSNLDNSIIAIT 403 Spathaspora pas...
XP_002546739 356 LSPFKTDIEFQGLKIYKNIltqDLISQMAFLPAGdDferd--enskEEDEDD--KELAKYYkIFdepnsSNLDNSIIAIT 431 Candida tropica...
Q59ST8       356 LSPFKTDIELSGLKIYKNVltkDLLSQMAFLPGGdDfekd--etnpEEDPEK--KQLEKYYqAIedpnsSNLENSIVAIT 431 Candida albican...
A3LNJ3       349 LSPFKTDIDVNDHTIYKCVlssDVNSALSFLPAep--------------------------------ssSNLDNSILAIT 396 Scheffersomyces...
Q6BU98       363 LSPFKTELDAKDFVIYKCVdssEANSNLSFLPSGdSftpeasemsdGDKKEE--FSLDTYYsQLqepssSNLDNSIVAIT 440 Debaryomyces ha...
A5DJW8       360 LSPFKTEVDVKDFRYFKGVlssDFNPSLSFLPSGdSyttd--dmdeDRKKDE--NSMDKFYtALedpdaSKLENLIIAIT 435 Meyerozyma guil...
EGV66140     190 LSPFKTEITISDFVFYQPVdssEFNSSLLFAPSGdSfapd---ateETEKKE--DTLDKYYkKIddfsaNNLENLVLAVT 264 Yamadazyma tenu...
4OHY_A       374 RST-KAD---ENVLKSPVFGFCLVTEVDLEKRTMSILCPQRT-IPSKVLVFSDITHLD 426 Caenorhabditis elegans
XP_002617501 408 QLD-ASEe-pSKLLETSVLGYVHVSTVDDTKQRMSMLLPFPGqIPRKVLIATDIRYTE 463 Clavispora lusitaniae ATCC 42720
XP_004200870 441 QLPsRNNs-pKDLLNACVLGYAHASKVEDTKQKIKVLVPFPGaFPRNHLIVTAIRYTE 497 Pichia farinosa CBS 7064
EGW31230     404 QLPqTNKs-pRDLLNSSVLGYVHVSKFDDDKKKLKVLLPFPGvFPRNVLIATNIGYNE 460 Spathaspora passalidarum NRRL Y-27907
XP_002546739 432 HLSnNDKkigRDLLNTSVMGYVHVSKFDDDKKRLKILLPFPGaFPKNVLISTNIGYSE 489 Candida tropicalis MYA-3404
Q59ST8       432 HLPnNDKklgKDLLNTSVLGYIHVSKFDDQKKRLKVLFPFPGvFPKNVLISTNIGYNE 489 Candida albicans SC5314
A3LNJ3       397 QLPsTHKs-gRELLNTSILGYVHVSKFDDAKGKIKVLLPFPGgFPRNMLISTNIGFNE 453 Scheffersomyces stipitis CBS 6054
Q6BU98       441 QLPqNNKs-aRDLMNTCVLGYAHVSKFDDTKSKMKVLLPFPGaLPRNILISTSVGYTE 497 Debaryomyces hansenii CBS767
A5DJW8       436 QLPqNNKq-pKDLLNTCVLGYIHVSRVDEARGKMKVLSPMVAaIPRNILLVTTIGYTE 492 Meyerozyma guilliermondii ATCC 6260
EGV66140     265 QLPaTNKs-pNDLLDACILGYVHVSKYEESKGRLKVLLPVPGaFPRNILIATKIGYTE 321 Yamadazyma tenuis ATCC 10573
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