Conserved Protein Domain Family
CrgA

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pfam06781: CrgA 
Cell division protein CrgA
CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.
Statistics
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PSSM-Id: 399633
Aligned: 72 rows
Threshold Bit Score: 61.134
Threshold Setting Gi: 410821791
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_006368633              1 MPKSKVRK-KTDYTIN-------PASRTPVKVK-AGPSSSIYVGVMLGLMLLGLAWLIVYYLAAGETTyggpgqalhWMN 71  Gord...
PRJNA329150:BB341_13880   1 MPKSRIRK-KADFTPPpnn-rqaTAIKLTNR--------SWVAPVMLGLFLIGLAWIVLFYVTEGELP----------IK 60  Stre...
ESQ05345                  1 MPKSRIRK-KADYTPPpak--qsTEIKLTSR--------SWVAPVMLALFLIGLAWIVVFYLTDGSLP----------ID 59  Stre...
BAJ29730                  1 MPKSRLRK-KADYTPPps---taTAVKISSG-------RSWVAPLMLVFFLVGLVWIVTYYVTSGNWP----------VG 59  Kita...
WP_007824467              1 MPKSRIRK-KADYTPPpaakqqaTTVKLSNG--------SWVAPLMLAMFALGLAWIVVFYVTDGSLP----------ID 61  uncl...
WP_012917743              1 MPESSSREqKKkp---------aAEKPQKTPKKpRTTSRPWVAPLMLGCWLLGLIWLVVFYVAGQDIP---------FMN 62  Krib...
WP_013160146              1 MPESQSRKkAQ-QKKAaknkqaaATKSAKNREAvNVSSRAWVPWVFVPMGLLGVIWLVVYYIGGQQIP---------LMY 70  Prop...
WP_013866120              1 MPESRTRKsAEtkk------kqqATAEAKPKKVkSPGGGRWVAPTFITVGLLGVLWLIVFYVGGQHIP---------FMA 65  Micr...
lgeUNICAMP:PACID_05650   46 AKAAAEKEeAA-----------------LERKRrVSMDRSWVPGVFVPVGVLGVLWLVVYYIAGAQIP---------FMM 99  Acid...
Q6ABC6                    1 MPESKVRPqAK---KKaqakdraTMDERRAEKKaAPVDRSWVPKVFVPLFLLGVLWLIVYYIAGNQIP---------GIS 68  Cuti...
WP_006368633             72 NLGAWNFLIGFSMMVVGLLMTMKWR 96  Gordonia
PRJNA329150:BB341_13880  61 SIGDWNIVVGFGFIAAGFGVSTQWK 85  Streptomyces clavuligerus
ESQ05345                 60 SFGNWNIVIGFGFIAAGFGVSTQWK 84  Streptomyces sp. PVA 94-07
BAJ29730                 60 SWGNWNILAGFGFIAAGFGVSTQWK 84  Kitasatospora setae KM-6054
WP_007824467             62 SLNNWNILVGFGFIAAGFGVSTRWK 86  unclassified Streptomyces
WP_012917743             63 DLGNWNLLIGMGLIAVGFVVSTQWi 87  Kribbella flavida
WP_013160146             71 ALSNWNFVIGLGLIAGSFFVATLWK 95  Propionibacterium freudenreichii
WP_013866120             66 ALGNWNILIGMGAMAASFGIATLWK 90  Microlunatus phosphovorus
lgeUNICAMP:PACID_05650  100 ALGDWNILIGMGAMAAAFAIATLWK 124 Acidipropionibacterium acidipropionici ATCC 4875
Q6ABC6                   69 DLGDWNILIGMGLMAAGFGVATLWK 93  Cutibacterium acnes
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