Conserved Protein Domain Family
IcmF-related

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pfam06761: IcmF-related 
Intracellular multiplication and human macrophage-killing
This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.
Statistics
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PSSM-Id: 399621
Aligned: 117 rows
Threshold Bit Score: 133.233
Threshold Setting Gi: 123590157
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8XRR8               490 ALDILQDRIEQlERFRgeh-plALSLGLyqgdaLQHKLLDEYYNGLRQVMLKPVGGALETFLAEVnTHPeqlapmvrppe 568  Ralsto...
Q88FL8               529 PLDQIRDAVAV-FGDYraawpgVADLGLyqgrtIGPTVDEAYLSLLSRRFLPALASGVIEAMDA--APP----------- 594  Pseudo...
CBV42794             535 PLDRLLSATQE-FGDYrsrpwlLADMGLyqgheLGVEIDNGYLRLLEEQFLPALMIGIMDDMNR--APE----------- 600  Halomo...
Q0ACM3               528 ALDELREVAGV-FDGPrgawagLADMGLyqghrVGDAMDQAYLDALRYRFLPALMLGIADEMNT--LAP----------- 593  Alkali...
WP_011705725         504 RLNLIREATLS-FGNYrermplVADLGLyqgdeIGPYVEGSYLQLLSLRFLPAQMQGLLADLNQ--APA----------- 569  Aeromo...
WP_013185714         521 QLNPIRDATLA-YGNYhenasfLTDMALyqggsVGPYVATTYRKLLEQRFLPALMLGLLDDLNQ--APA----------- 586  Xenorh...
CBJ79427             521 LLNPIRDATLA-YGNYhekksfLTDMALyqgdgVGPYVEGTYLKLLEQRFLPSLMQGLLDDLNR--APA----------- 586  Xenorh...
Q7N9J5               515 LLNPLREATLA-YGDYhqk-glLADMGLyqgaaVGPYVENTYLQLLSQRFLPALMNGLLDDLNR--APK----------- 579  Photor...
JLExeter:vfu_B00780  471 sLSELRDINNL---YDkqhrpwYVSDWLpd-ssIRRFVHQTYYEELSSVLLTLMRDYILKDLFVYnSLD----------- 535  Vibrio...
WP_002415809         510 LLNPIRDATLA-YGNYherspfLADMGLyqgnnIGPYVESTYLQLLQQRFVPALMSGLLEQLNA--APK----------- 575  Yersin...
Q8XRR8               569 tgaviatsvtsatatiaasgaaagapasasptatataaapagkrftdaspsNVEDGYNALKTYLML-SDKRHVEVAHLTD 647  Ralsto...
Q88FL8               595 ---------------------------------------------------GSEQQMAALRVYRML-EDRRNRRAEWVED 622  Pseudo...
CBV42794             601 ---------------------------------------------------GSNEKLALLRILRMM-SDASGRQPQRVHD 628  Halomo...
Q0ACM3               594 ---------------------------------------------------GSEEQLVRLRVLRML-ADARGREPDRVRD 621  Alkali...
WP_011705725         570 ---------------------------------------------------GSEEKLAILRVMRML-DDASGRNKELVAQ 597  Aeromo...
WP_013185714         587 ---------------------------------------------------SSEEKLEILRVMRMM-EDKSQRNSALVAQ 614  Xenorh...
CBJ79427             587 ---------------------------------------------------GSEEKLEILRVMRMM-EDGSKRNNGLVGQ 614  Xenorh...
Q7N9J5               580 ---------------------------------------------------GSEEKLAVLRIMRML-EDGSGRHKSLVEH 607  Photor...
JLExeter:vfu_B00780  536 ---------------------------------------------------DKVKMLELLNYHQILyS-KHRDDVDSLVN 563  Vibrio...
WP_002415809         576 ---------------------------------------------------GSEEKLEILRVMRML-EDGSGRNAALVEQ 603  Yersin...
Q8XRR8               648 QITRFWRGWLEDNRGNMpreqmirsaERNLSFFLARVNDdnwp------------llegNLSLIDQTRENLrrvvRGMPA 715  Ralsto...
Q88FL8               623 WMARQWQQAFPGQGQLQ---------RDLMRHLKYALTYadtdl-------------pqyrQRVSHVQQTL----RKVPL 676  Pseudo...
CBV42794             629 FMEDRWQEAFPGRGEVQ---------RRLLAHLDYALAYtdlaghaeagqsgarqamaplDGSIEAAQQEL----ARQPM 695  Halomo...
Q0ACM3               622 YMADRWQALLPNRGRLQ---------GRLLEHLDHALVHtdlagrqahd-praaaalapvAGSIRKAQQAF----SRSPV 687  Alkali...
WP_011705725         598 YMASRWQKAFPGQGAVQ---------EQLMGHLDYALDHtnwygaraerdqaaitafvpfKEPVYGAQREL----GKLPM 664  Aeromo...
WP_013185714         615 YMRERWSKAFHGQRNIQ---------DALLTHLDYALDRtdwkelrdkgdkeaitnfapfVKPIRQAQDEL----KALSV 681  Xenorh...
CBJ79427             615 YMRARWSKAFHGQRDLQ---------AQLLTHLDYALAHtdwkgqrdkdnqdalarfapfIKPMKQAQQEL----SALTI 681  Xenorh...
Q7N9J5               608 YMQARWSQAFNGQRPLQ---------AQLLTHLDYALDHtdwraareagdqaaisrfapyQLPLINAEKEL----SQLSI 674  Photor...
JLExeter:vfu_B00780  564 YYLTSLKEEGEGDVALL---------ERFTALAEDLLRSgatp-------------pdaEPELLALVRKSL----SANDI 617  Vibrio...
WP_002415809         604 YMSHRWSQQFNGQRELQ---------EQLSSHLNYALKHtdwhgaresgdqyaiksfvpyLRPIQSAQQEL----SKLSI 670  Yersin...
Q8XRR8               716 RERAYAEIKARA---STRyAPMTVARIVGETGGNVIAGSY---------AVPGTFTKEAWQGYVQPAIREAASKELQTKd 783  Ralsto...
Q88FL8               677 PQRVYAGLKQQAq-eQLH-TGLDLRHQVGPAFDVVYQLSSgssqgdngvLLAPMLTAKGFKEYFEPRSQRFTEMAMIDQ- 753  Pseudo...
CBV42794             696 AERVYASLKSGId-eHRA-APLDLRSSVGSSFSLVFMARDdnp---elvRIPGLLTRNGFEDYFLDQLDQATELALVDT- 769  Halomo...
Q0ACM3               688 DERVYTLLKRRGq-dRAG-GGVRLDRSVGSGWGTVFRADDddp---dgvTVSPLLTRDGFEQVFLGELDGATVLALNDL- 761  Alkali...
WP_011705725         665 YQRVYQNLVVKAg-dVLP-PDLNVRDEVGPTFDTVFALRsdn-----agQVPRLLTWPGFNDFFLKQDKALIDLTAMDA- 736  Aeromo...
WP_013185714         682 KQRVYQNLRIRAq-dVLS-APLNLRDQIGPSFDDVFVASnek-----rlVIPQLLTRHGLMDYFVRQKDELTKLTEMDS- 753  Xenorh...
CBJ79427             682 NQRVYQNLRLKAq-dTLS-APVNLRDQIGPSFDSVFIAGnes-----rlVIPQFLTRHGLTDYFVRQDKELVELTEMDS- 753  Xenorh...
Q7N9J5               675 YQRVYQNLRIKAq-dSLP-PPLNLRDQIGPGFDRLFMANndk-----qlIIPQFLTINGLNNYFVKQDDQLIDLTVMDS- 746  Photor...
JLExeter:vfu_B00780  618 SELLYQHILQHPdfsRR----VDMRTKLNPSYQHVFVFKPgft----gyLIPYLFTREGFEDLYNETGFQLASEAIKSYe 689  Vibrio...
WP_002415809         671 YQRVYQNLRIKAq-dALP-PALDLRDQIGASFDDIFVSGndr-----llVIPQFLTRSGLQSYFIKQNDQLVDLTVMDS- 742  Yersin...
Q8XRR8               784 WVLNvaardd------------ltlegSPEQIQKTLVTMYKTEYAREWQRFMQGVAVQDFTSFEQAVAGMNLLGDPTnSP 851  Ralsto...
Q88FL8               754 WALGeraql-------------dysdaDQAALNERLRNLYSADYIDSWRRALNAFSVADFRDLDHGVTILEQLAGPA-AP 819  Pseudo...
CBV42794             770 WVLGqrddi-------------dfseaDHRQLQEALRERYISDYHVTWREALADIRMVPLPDIHQAVVVADGLLSAS-RP 835  Halomo...
Q0ACM3               762 WVLGerddp-------------qfserDEQRLREALREQYVADFHAGWRRALGNIHLTDLESIPHAVIVIDALLGGG-RP 827  Alkali...
WP_011705725         737 WVLGqrkls-------------qlseaDRKEITRQVNDRYVTDYVNQWQKLLTNLDVQTLESPEQALDVLAAITGND-QP 802  Aeromo...
WP_013185714         754 WVLNiaknnqdkaseaglqnndqystkDQERILNDINDLYLSEYTATWRAAMNNLEVRDFDDLPHAISAIEQVISGE-QP 832  Xenorh...
CBJ79427             754 WVLNlplktn------------kysdtDQGNIQREITELYVGDYTATWRAAMNNLEVRDFEDLPQAISAIEQVISGE-QP 820  Xenorh...
Q7N9J5               747 WVLNlshnv-------------qysdtDRQEIQRQITEQYLGDYTATWRAAMNNLDIRDFTDIPQALSALEQVISGE-QP 812  Photor...
JLExeter:vfu_B00780  690 GVMGnis-----------------gdaEMNRINRQLRERYIGDYVRYWQALMANVSWVDVSGWGEVSKQIEMTVDPVySP 752  Vibrio...
WP_002415809         743 WVLNltknv-------------eyseaDRKEIHRQVTEQYLGDYTATWRAAMNNLSVSDFEGLPQAISAIEQVISGE-QP 808  Yersin...
Q8XRR8               852 IRKVLDTAYDQTS 864  Ralstonia solanacearum
Q88FL8               820 LHRLLETVRDNSS 832  Pseudomonas putida KT2440
CBV42794             836 LDRLLGEVADQTR 848  Halomonas elongata DSM 2581
Q0ACM3               828 LERLLAEIERHTR 840  Alkalilimnicola ehrlichii MLHE-1
WP_011705725         803 FQRVLASLDDNTR 815  Aeromonas hydrophila
WP_013185714         833 IKRALQILSDNTN 845  Xenorhabdus nematophila
CBJ79427             821 IKRALQILSDNTR 833  Xenorhabdus bovienii SS-2004
Q7N9J5               813 ISRALQILSDNTR 825  Photorhabdus laumondii subsp. laumondii
JLExeter:vfu_B00780  753 LSQFYHLVAVHTN 765  Vibrio furnissii NCTC 11218
WP_002415809         809 FRRALQTLSDNTR 821  Yersinia pestis
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