2L0Y,2ZXT,5LDW


Conserved Protein Domain Family
CHCH

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pfam06747: CHCH 
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CHCH domain
we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterized proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesize the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit. The CHCH domain was previously called DUF657.
Statistics
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PSSM-Id: 399611
View PSSM: pfam06747
Aligned: 50 rows
Threshold Bit Score: 30.3037
Threshold Setting Gi: 563403606
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L0Y_A        68 CGEQFKSAFSCFHYSTE---EikGSDCVDQFRAMQE-CMQK 104 human
CDK13602      73 CGNFFRELYICMKSDDT---RdpSEKCPNQFVNWAA-CMQN 109 Caenorhabditis elegans
Q8GYJ4        79 CGSQFSEAFLCFLKSTA---EekGSDCVNPFVALQS-CINA 115 thale cress
Q19342        72 CGYEFREAISCQKTSSDeemE--NGACGEQLMAFME-CAMR 109 Caenorhabditis elegans
P34415        66 CGFEFREAITCQKTNSDgeiE--QGACGKELMSFME-CVTR 103 Caenorhabditis elegans
Q8LGE7        71 CQKEMDDYVGCMYYYTN---E--FDLCRKEQEAFEKvCPLK 106 thale cress
Q8BT51        34 CAASHFAVQECMAQHQD------WRQCQPQVQAFRD-CMSA 67  house mouse
Q05809        39 CYVENLALQLCHAETGD------WRQCFNEMALFRK-CWEK 72  Saccharomyces cerevisiae S288C
XP_002043109  80 CHEEFTQYATCLDKSSG---TmaFSHCRKTQGVFDK-CIKd 116 Drosophila sechellia
5LDW_X        78 CAEPFTEYWTCIDYSGL---Ql-FRRCRKQQAQFDE-CVLD 113 cattle
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