Conserved Protein Domain Family
IcmF_C
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pfam06744: IcmF_C 
Type VI secretion protein IcmF C2-like domain
IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.
Links
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Statistics
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PSSM-Id: 429094
Aligned: 109 rows
Threshold Bit Score: 53.4899
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
MPITM:COCOR_04151 1144 MQVRPLplpsapTPDSFVTLSYLKCGGaASFGFNQRPAwGEFPLSWWSPqpssiGVELRSPqrDGKRYR-SMEMSESSWN 1222
WP_025330511       949 FEIMPL------P-TPEVKQITFNFNK-QKIQFYNEKS-FWHKVNWSVSdstdkKASIQWSd-VTDKT--AQLEVVGDLS 1016 Snodgras...
wugsc:KPN_02251    988 FALRPG------T-ADGVMQTELVIDS-QKLVYMNQMP-VWRRFSWPADte-apGASLSWVs-TRAGTR-QYGDFPGAWG 1055
Q7MZR3             968 FELRAK------P-VGDVAETDLTIDS-QQLRYFNQME-RWQRLRWPGDgd-npGVALTWTg-VNSGAR-LYGDYPGAWG 1035 Photorha...
Q7N256             970 FELRAR------A-VRDVVETDLTIDG-QKLRYFNQME-SWQSFRWPGEty-kpGVMLTWTs-VNAGAR-LFGDYQGNWG 1037 Photorha...
WP_012733090       999 YELRPE------P-TPGITDMKFVLSG-RELRYFNQKQ-EWTPFEWPGQsl-enLSHIEWQt-EQGGLR-TALDSQGRFG 1066 Burkhold...
WP_012237617      1105 FHINMK------TVSPIVSEVVFEVDG-QKRLYRNEKE-FWHTFNWPGeg--akGARIQVR--GAGGLD-EELVREGPWG 1171 Sorangiu...
CAV18458          1007 FQVKAV------DMTPNITEFSIISDK-PIFTYRHGPT-LWSQQSWQGds--efIEKLGVQlnAQDSII-GQSTVKGTWS 1075
Q02CI0             986 YSLKP-------ETTEGVQMLTVRLDG-QTLTYNAGTAaAFKKFNWQGsg--thEALLSVR---FGTQDlGLASGEGLWA 1052 Candidat...
EIT41190            40 FELLAR------P-VPNVVETNLAIDG-QKLHYFNQME-SWQSFRWPGEty-kpGTMLTWTg-VSSGAR-LYGDYQGTWG 107  Yersinia...

MPITM:COCOR_04151 1223 CFRLLESaTLTDQSNVvwvlpGRGLAA------NEKVLEISFGLRG 1262
WP_025330511      1017 ILRLLEKa-QARKNDD-----DTYHLKwi---iKNRVVEMNLKNLQ 1053 Snodgrassella alvi
wugsc:KPN_02251   1056 WIRLLDKa-VVSAYPGt---sSSWSLSwk--apDGLLLNYTLRTEA 1095
Q7MZR3            1036 FIRWLEAa-QVQMVDE-----SRYRLNfa--tpEGLALTWILRTEV 1073 Photorhabdus laumondii subsp. laumondii
Q7N256            1038 LIRWLAQa-KAEKLDE-----SRYRLIft--apDGLPLTWILRTEL 1075 Photorhabdus laumondii subsp. laumondii
WP_012733090      1067 LIRLLERa-KVSQQDS-----ARYLLSwtpdtsLGLPLRVQLRSEV 1106 Burkholderia glumae
WP_012237617      1172 IFRLFEAgTTTAQKDNd----ELFTVTwq---mTAPPVTVTMEIRP 1210 Sorangium cellulosum
CAV18458          1076 WFRLFGPnVSFSSA-------QDTQVEfv---yGDSKVKLTIKTQG 1111
Q02CI0            1053 AFHLFQLaDTQSAGAG-----GTQVLDwv---aKSGKAGQPMLLGS 1090 Candidatus Solibacter usitatus Ellin6076
EIT41190           108 LIRWLEQa-KQKKLDE-----GRYQLTft--taDKQPLQWILRTEL 145  Yersinia pestis PY-99
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