Conserved Protein Domain Family
FAST_1

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pfam06743: FAST_1 
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Statistics
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PSSM-Id: 399608
View PSSM: pfam06743
Aligned: 124 rows
Threshold Bit Score: 47.1004
Threshold Setting Gi: 780028080
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDV27484     374 CQLIYSLGKMNFKLElpasK---KFFPIVIQRLEDLMKrqnRYTPKFykqVISATWSLIIMEQFPPRLISKILSDQFIED 450 Trichoplax adha...
XP_003762603 365 SNMILTFARLNFHPE----Qe-eQFFSLVHKKLESELD---KLSPGL---QVDVVWSLCILQQVQKKQLQEVLCQDFHNQ 433 Tasmanian devil
XP_015444541 366 CNMLLAFARLNFRPE----Le-dRFFSLVHEKLEPELA---RLDPGL---QVDVLWALCVLQQAREAELQAVLRPEFHRQ 434 black flying fox
XP_003418662 371 CNVVLAFAHLNFRPE----Qd--PFFSLVHEKLALELT---SLSPAL---QVDVVWALCVLQQVQEAELRAILCPEFHTQ 438 African savanna...
XP_539807    372 CNMLLAFAHLNFHPE----Qe-dQFFCLVREKLGSMLS---GLPPAL---QVDVVWALCVLQQVQEAELRAVLCPELHTQ 440 dog
XP_012665438 371 CSMVLAFARLNFHPE----Qe-dQFFNLVHEKLEPALA---GLEPAL---QVDLIWSLCILQQAREKELRAVLCPEFHAQ 439 small-eared galago
Q91YM4       368 CSVLLAFARLNFHPE----QeedQFFSMVHEKLDPVLG---SLEPAL---QVDLVWALCVLQHVHETELHTVLHPGLHAR 437 house mouse
XP_003465836 370 CSVLLAFSRLNFHPQ----Qg-nQFFKLVHERLGPELA---SLEPAL---QVDVVWALCVLQQVQETELRAILDPSFYTQ 438 domestic guinea...
ELV11813     517 CNVLLAFACLNFRPQ----Qe-dQFFSLVHERLGPKLA---GLKPAL---QVDLVWALCVLQHVQEAELRAILHPDFHAQ 585 Chinese tree shrew
XP_017380066 374 CSMLLAFARLNFHPD----Qe-dQFFSLVHEKLGSELA---GLEPAL---QVDLVWALCVLQQAQEAELQTVLHPKFHTQ 442 Cebus capucinus...
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