4A15,5FMF


Conserved Protein Domain Family
DEAD_2

?
pfam06733: DEAD_2 
Click on image for an interactive view with Cn3D
DEAD_2
This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast.
Statistics
?
PSSM-Id: 399602
Aligned: 21 rows
Threshold Bit Score: 156.27
Threshold Setting Gi: 74842874
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4A15_A   56 YLVRTNSQEEQVIKELRSLSst----------mkIRAIPMQGRVNMCILYRMVDDLH--EINAEslaKFCNMKKREVMAG 123  Thermoplasma acidop...
Q8IE72  226 ICSRTQSQLNQYFHELKKIEkkmg------edfsINMIIIGSRKHLCINEAFLKKYKn-INELN---DCCKNSKCKYKEI 295  Plasmodium falcipar...
P22516  235 YASRTYSQLGQFTSQLRL-PsfpssfrdkvpdekVKYLPLASKKQLCINPKVMKWKT--LEAIN---DACADLRHSKE-- 306  Saccharomyces cerev...
Q9CA92  187 FCSRTHSQLSQFVKELRKTVfa----------kkLKVVCLGSRKNLCINEDVLKLGN--VTRIN---ERCLDLQKKKISQ 251  thale cress
Q9XZS9  192 FCSRTHSQLAQIVAELRKTPhg----------qsVRSISLGSRQQLCGNPAVRKLKH--VGLMN---ERCLDMATKKARP 256  fruit fly
Q96FC9  231 YCSRTHSQLAQFVHEVKKSPfg----------kdVRLVSLGSRQNLCVNEDVKSLGS--VQLIN---DRCVDMQRSRHEK 295  human
Q9NZ71  111 YASRTHSQLTQVINELRNTsy------------rpKVCVLGSREQLCIHPEVKKQES--NHLQI---HLCRKKVASR--- 170  human
Q9W484  111 YASRTHSQLTQAMRELKRTay-----------anMRSVVLGSRDQLCIHPEVMREQGn-SNKTN----MCKLRVHSK--- 171  fruit fly
Q93575  107 YASRTHSQLEQVVHELNRTey-----------kwVKTTILGSREHFCINQKVKKIKEsnRQA-----HVCRGLVSKRA-- 168  Caenorhabditis elegans
Q8IM12  126 YASRTHSQLKQVIKELKNVYfiknn-----ekykLLTTILGSRDQLCVH-NINYNYK--GTLLN---NMCKRTRKNG--- 191  Plasmodium falcipar...
4A15_A  124 ne--------------------aACPYFNFK----IRSDET---KRFLFDELPTAEEFYD------YGERNNVCPYESMK 170  Thermoplasma acidop...
Q8IE72  296 ynekmsekwkkkngkkkrifydsSCSSNSSEnediETIDNYiliTKLINNRNVDIEDIKDi----cKNEHIEICPYYLSK 371  Plasmodium falcipar...
P22516  307 -----------------------GCIFYQNTne-wRHCPDTlalRDMIFSEIQDIEDLVP------LGKSLGICPYYASR 356  Saccharomyces cerev...
Q9CA92  252 vskkknlgan---vrivrtkascRCPMLRKHkl-qREFKA-----ESFQQEAMDIEDLVQ------LGREMRTCPYYGSR 316  thale cress
Q9XZS9  257 npskksr---------ltaeansRCPFk------aASLVESl--RDLALTEPLDIEELAN------EGTACGGCSYYASR 313  fruit fly
Q96FC9  296 kkgaeeekp-----krrrqekqaACPFY-NH----EQMGLL---RDEALAEVKDMEQLLA------LGKEARACPYYGSR 356  human
Q9NZ71  171 -----------------------SCHFYNNV-----EEKSL---EQELASPILDIEDLVK------SGSKHRVCPYYLSR 213  human
Q9W484  172 -----------------------TCSFQMRV-----ESRKDh--PDLRGPTIMDIEDLVK------VGQRLKICPYFASR 215  fruit fly
Q93575  169 ------------------------CHYYNKFd--aCTTDKMt--EFLDKGEAMDIEDFVK------LGTQNSLCPYFMSR 214  Caenorhabditis elegans
Q8IM12  192 -----------------------ECIYHNGL----KYLYKL----KHLFTTPMDVETLSEigkgnsVGQNIHFCPFYATR 240  Plasmodium falcipar...
4A15_A  171 AALPDADIVIAPYAYFLNRSVAEKFLshwgVSRNQIVIILDEAHNLPDIGRSIGSFRISVESL 233  Thermoplasma acidophilum
Q8IE72  372 ENIKNADIILLPYICILNENIRNNLK----INIKNNIVIFDESQNIIENINSCNSVSISNHHI 430  Plasmodium falciparum 3D7
P22516  357 EALPIAEVVTLPYQYLLSESTRSSLQ----INLENSIVIIDEAHNLIETINSIYSSQISLEDL 415  Saccharomyces cerevisiae S288C
Q9CA92  317 RMAPAADLVILPYQSLLSKSSRESLg----LSLKNSVVIIDEAHNLADTLLSMHDAKLTVSQL 375  thale cress
Q9XZS9  314 SAVEHAQLILLPYQLLLQKSARNQLg----ISLKGSIVIVDEAHNLLDSVAQLHGSEISRQQL 372  fruit fly
Q96FC9  357 LAIPAAQLVVLPYQMLLHAATRQAAg----IRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQL 415  human
Q9NZ71  214 NLKQQADIIFMPYNYLLDAKSRRAHN----IDLKGTVVIFDEAHNVEKMCEESASFDLTPHDL 272  human
Q9W484  216 ELVPQADITFMPYNYLLDPKARKANK----IELGNTIVILDEAHNIEKICEESASVQIKSSDV 274  fruit fly
Q93575  215 QRSETAELILLPYNYIIDPKMRRRYK----LDLKNSIVIFDEAHNLESICESNASAELTSTSI 273  Caenorhabditis elegans
Q8IM12  241 EIQNECHIILLPYNYLFEESTRKILK----LNLENSIIIIDEGHNIENVAEEAVSFKLKDTDL 299  Plasmodium falciparum 3D7
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap