Conserved Protein Domain Family
PIG-U

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pfam06728: PIG-U 
GPI transamidase subunit PIG-U
Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
Statistics
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PSSM-Id: 399599
View PSSM: pfam06728
Aligned: 52 rows
Threshold Bit Score: 170.482
Threshold Setting Gi: 74842832
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002291238      71 LTQLLGRGILPSiRAAVLDpIHTWSHLEEacfwkdnapslwmdvavahSTVGNSADA-SDdVVRKAKGGySAIYTPGTrI 149 Thalassiosi...
A0DGJ7             1 MYRIILILKCLLwYFGKWD-VDLTWLPYF-------------------SNPYTQYSNiRE-AKYLIANN-YNPYNTDG-I 57  Paramecium ...
Q8IE19           127 LELYFQKNKRYN-NLRSFLlKNDYMHYLF-------------------NTDIYNLKYlYDsYVLRILKK--DMYSSLV-I 183 Plasmodium ...
CAQ41297          95 LQEYFQRNKRNG-KIKQFLlKNDSMHYSF-------------------NSDLYNLKYiYEsDILGRLSA--DVYSSLT-V 151 Plasmodium ...
ESS28069          75 aVGVALRLFLYS---VGLT-LSESTEPLV-------------------SPASASFSSfRE-ALTLHALS-FSPYTGGV-Y 128 Toxoplasma ...
Q5CYY5            10 IISILIKLSF---FILVEHdLEDYTNGFF-------------------GILGQNFGEvLE-FCALKEYG-ISTYYESKrV 65  Cryptospori...
Q22672            31 SAAIAVRAVCASyS------DLFEERVEL-------------------TSVVYSFEKlKD-SIAMVDDG-LNPFEAKN-M 82  Caenorhabdi...
XP_002639921      27 SAAIAVRAASFAyS------DYFEERVEF-------------------TSTVYSFERvKD-GIAMLDDG-LDPFETKN-M 78  Caenorhabdi...
jgi:MICPUN_60372  13 AAGVLARVLL---AILGWT-ESASERLEL-------------------ASPVDALARiRE-GHALWGMG-QSPYGGSA-L 66  Micromonas ...
EEH56751          13 LASVLLRFVL---AARGWG-EILHARPEL-------------------SSAVDAATRlRE-GDALRRLG-QSPYAGSA-L 66  Micromonas ...
XP_002291238     150 VSPPLVVAFLGETlvcp-----------sihiNTTLLWVI-------------QQLLLLAADGIGALCIYHIgkriceme 205 Thalassiosi...
A0DGJ7            58 FQKPLIVYGLNLI--------------------------D-------------NDIIFLIADILVCFLIVQLf------- 91  Paramecium ...
Q8IE19           184 RINPIFLKILHFLlfkpikinidvlikicnnyEFR------------------FFLFICIIDILIAIFLFLIidkln--- 242 Plasmodium ...
CAQ41297         152 RINPLLLKALQFVlfreipiksgitkgnrngrSGEGATSRgvepfslnrpelrFFLLICAVDLLIGVLLFLItqrla--- 228 Plasmodium ...
ESS28069         129 RQQPLVFLSLKWLtgagrg--------adescNTSSCQWR-------------YYLVLIFIDLVAATALAVAaaeartwa 187 Toxoplasma ...
Q5CYY5            66 NFPAVFMELISGLcs---------------siNSKNGLIF-------------PFLAINLIQILQGILIYSYlik----- 112 Cryptospori...
Q22672            83 HFPPLTLHLFRFL--------------------LNTAPTM-------------ILPLFISIDVATTWILSSAa------- 122 Caenorhabdi...
XP_002639921      79 HFLPLTLYVVRYL--------------------LKTSPVL-------------LAPLWILLDISTAWIAAQSa------- 118 Caenorhabdi...
jgi:MICPUN_60372  67 HAPPLYLALVGPLv------------------ANAPAGLV-------------ASVPFIVADLVVAVAIHRVa------- 108 Micromonas ...
EEH56751          67 HAPPLLLAALAPRiasap------------------------------tigtrAVAPFVVFDVLAAFALFFAsrriea-- 114 Micromonas ...
XP_002291238     206 ekseegeierqttsskntlgerstdlmvpeilrpergwvfglaykvllsdeSLGILEKRPEKQKTDkaansngnssyvtn 285 Thalassiosi...
A0DGJ7            92 --------------------------------------------------gAKQGYRMS--------------------- 100 Paramecium ...
Q8IE19           243 ----------------------------------------------nwntyFLYIISNNYTTPHFNi------------- 263 Plasmodium ...
CAQ41297         229 ----------------------------------------------rwevyFRYVNEDTRDAqw---------------- 246 Plasmodium ...
ESS28069         188 vswrqkdwe--------------------------nstdvtrekgpsergkTLAKGseeshqqp---------------- 225 Toxoplasma ...
Q5CYY5           113 -------------------------------------------------syPILSTISKTIIEKNNy------------- 130 Cryptospori...
Q22672           123 --------------------------------------------------dVVWRQTHGSS------------------- 133 Caenorhabdi...
XP_002639921     119 --------------------------------------------------qKVWKSVHGRDDR----------------- 131 Caenorhabdi...
jgi:MICPUN_60372 109 --------------------------------------------------tASTRTSRARGSDAADas------------ 126 Micromonas ...
EEH56751         115 ----------------------------------------------rrivwSRAGSAGGPGASAAAkreas--------- 139 Micromonas ...
XP_002291238     286 dhyqqiltlqLVPLVASIVYFSNPISMIANATGSLRSLWDALLLLSLYYATlPpttlTKegapi------krpsASKSAL 359 Thalassiosi...
A0DGJ7           101 ---------------ISLFYHLNPITFANLILKNTNVFDHIFLLLTILSALkM---------------------KILSPI 144 Paramecium ...
Q8IE19           264 ----------INPLLLINIYLNNPINILANSFLSLDNFKLLIITANFYLTLsRiqnvSNqqkqnvyknkykricSFFNLL 333 Plasmodium ...
CAQ41297         247 --------nlIDPILLMNIYLNNPLTILSNSFLSFDNFKLLLITTSFYLTLrRirseASppqs-----------stpNLI 307 Plasmodium ...
ESS28069         226 --rdgveeivATPALVAASYFLHPMTIGAILSLTIHTLPLAFFASALACAT-Rag-wLS---------------RWLSVV 286 Toxoplasma ...
Q5CYY5           131 ---------eLCVNMLVGIFWINPISIYTSSLLSFGIEFELFLQLLLLWISiDss-hKF---------------RALLPI 185 Cryptospori...
Q22672           134 ----------SIRKLIFSLYAFNPITIVSTGILSLTVIQNFVSAVILLSLVtDr--------------------PTICAI 183 Caenorhabdi...
XP_002639921     132 ----------NIGKLVFSLYAYNPIAIISTGILSLTVVQNFVFAAIFFFLVsDr--------------------PAVCAL 181 Caenorhabdi...
jgi:MICPUN_60372 127 ---------pTSPAWVVAMFLANPFSIASCAAASSAGFRAAALAVAVAGAV-E----GT---------------PVVAGA 177 Micromonas ...
EEH56751         140 ------rrvaSTPWTVAALSLANPLAIASCVACSCAGLRTAALAFLIFGASc-----GN---------------PHVAGF 193 Micromonas ...
XP_002291238     360 SLALATY-VDLAYAVFLLPILlwrgsl----------------------------sekpsqVNQHHDWKT---VLVLFLS 407 Thalassiosi...
A0DGJ7           145 LFGILLY-LNPQYFIVLAAISvifrr------------------------------dssktSKFAFKLII---FLLVSIA 190 Paramecium ...
Q8IE19           334 LILFHNA-ILLYITSFHFILVviginnfiiyiee--------------dflkryhikqnvqFCKLAHMLFknmFLLLITL 398 Plasmodium ...
CAQ41297         308 AILFVNA-MLLYITSFHFILVligvnhlliyihq--------------gimykyklkvplnFLHMLLILLqnlALLIATL 372 Plasmodium ...
ESS28069         287 FFGFSLY-VGPPQALLLALPLahllhavrtqtvq---------------rldllevlpspkKDILPGLLRg-tLLFFAGL 349 Toxoplasma ...
Q5CYY5           186 ISGINVYySPTVSISLIPSTLtlflsgnqhflkfntcpqlfdnfkmhfkhfwinflsnyfnfrnilKIIL---FFTSFTI 262 Cryptospori...
Q22672           184 LIGAWSS-FTIYPFILISCLVfr-------------------------------------sNGSIVKFLS---LVLVSAL 222 Caenorhabdi...
XP_002639921     182 LIGAWSS-FTIFPFILISCLAfr-------------------------------------aNGSLFKFLS---LVALSIF 220 Caenorhabdi...
jgi:MICPUN_60372 178 GCAALAYlGDPTCAALTVPSLaramareggfgee--------------gtgkkgkgkgragGGARSAFVH---LCAWIVG 240 Micromonas ...
EEH56751         194 GLATSAYlGGIAPLAMLFAPTasaiakggaeghrpgvdg-----gmrgreiarrsaaevsgHSPATATAK---LFAWTTT 265 Micromonas ...
XP_002291238     408 YLGGLHLlASALvGGDw----NEYkqvMLQTVLPNVSFVeqdSSGSvpgPCMGLHWYFFVQMFDRFQPYFVVLINGIPAM 483 Thalassiosi...
A0DGJ7           191 TICLLLY-NSYK-ITG-----DWQ---FIEKTYIDYYFP---KDHK---PTIGFLWALFSGLFSKYKSLYHAFFMLLPAC 254 Paramecium ...
Q8IE19           399 IIYALFIvISYFqNSH-----SLS---FLNNTVINEYKI---LLLL---PNLGNFWYIFSTMFRDYYYSFLFLFHFHIFL 464 Plasmodium ...
CAQ41297         373 ALYALLLlASAYvNSG-----SFS---FLNNTLINEYKV---LFLL---PNLGNYWYLFSTTFRDYYHSFLFLFHFHVFF 438 Plasmodium ...
ESS28069         350 AFCVLLHvASYFaLRAyt-adAAD---YLDSTVVSMWGV---RDLG---PNLGIFWYIFSLIFERYRLLFVMIFQGHCFI 419 Toxoplasma ...
Q5CYY5           263 TFLSLHI-FSFIiINHqnshhILTfkeYFYTFIVQNFTLlenKDLN---PYLNIYWFLMYCIASEFRLYFQIILGSCLII 338 Cryptospori...
Q22672           223 TTITFVG-INYLlNNQ-----SLN---FLGPVYASILNF---SSIQ---PNSGLYWYFFVQIFEHFRSFYTMSFVVLYFF 287 Caenorhabdi...
XP_002639921     221 SATTFFA-LNFLlNGN-----SLN---FVEPTYTSILKF---TSIQ---PNVGLYWYFFVQIFEHFRSFYTNSFVILYFF 285 Caenorhabdi...
jgi:MICPUN_60372 241 WIVALVG-VSQAvMSNa----RAApmdWIRATYGFRLVA---EDLS---PNLGCFWYFFTEMFDNFRVFFLFAFDYFPVA 309 Micromonas ...
EEH56751         266 WLFALTw-LSTDiLRG-----HASfddWFRACYVYLLVP---DDLA---PNLGAHWYFFSELFDHFVGFYRFVFAFFPAF 333 Micromonas ...
XP_002291238     484 FPIPLVIRLHRY-----PAVLVATFQLLWSIFR--PTTTVHTLALALILALLSPRsLVRMGN-PS--LISfFALPVTVIL 553 Thalassiosi...
A0DGJ7           255 YILPLYNLFVKYakrekEYLGFMIGVSLFCSFLyfQYIAISDLIIIFILLFQR----YDWLFnSLptIVIvHAGCLILFL 330 Paramecium ...
Q8IE19           465 YPVPLFFRLVKT-----PLIYLKVLIAIALVFQ--PNITINDIVYSLLLLVID----YERTIyAIpfIKLlLILLSNLCL 533 Plasmodium ...
CAQ41297         439 YPLPLLFRLVKT-----PLIYLKIMISIALVFH--PNITVNDIVFSLLLLVID----YKRTVyAIpfIKLiIIMLGNLGL 507 Plasmodium ...
ESS28069         420 LVVPLFVRMFRY-----PLAYCQVVIAIALLFQ--PSFCISDSAFLVSLLISRWH-IVER-KvAF--VKLiVVAFVAVSI 488 Toxoplasma ...
Q5CYY5           339 YAFILNISLEKI-----PFKALQSQLLLCFVFK--SNPTFINYLLIFFFILFDSVt-LFESKsGFlaSFSfVTWMICIPS 410 Cryptospori...
Q22672           288 MPIPITFLIRKD-----TILHFTIIGFLVSIFF--PYPTLNQVSLLLAFLPVHDV-YKKHFRyTI--LIA-GTIVSTVFL 356 Caenorhabdi...
XP_002639921     286 MPIPITIMIRRD-----PVLHFTIIGLLVSIFF--PYPTLNQVSFVLAILPLLEE-YKKHFRyTL--LIG-GAIITTIAL 354 Caenorhabdi...
jgi:MICPUN_60372 310 LCVPVVVRLGWDe----PLFCVFVARLLCVVFS--PYPTLGDASGYLALLPLFRAqLAGAGGlGY--LVA-AGYVASALL 380 Micromonas ...
EEH56751         334 LATPLTIRFIDSr----PTFAIFGVTCLGCIMH--PYPTLGDAARYLSLLPLFSEeLAAFHPgAA--FAVvAGFFYVILL 405 Micromonas ...
XP_002291238     554 FVTFHRMWLVTGNGNPNY-IFFQCLAY 579 Thalassiosira pseudonana CCMP1335
A0DGJ7           331 GGGLQLTWTHSFTGNPNFtFFQVFVSY 357 Paramecium tetraurelia
Q8IE19           534 CFVTLNLWLRKNTGNANYvFFNQLVVF 560 Plasmodium falciparum 3D7
CAQ41297         508 FFVTTNLWLRKNTGNANYvFFNQLIVF 534 Plasmodium knowlesi strain H
ESS28069         489 YPVTTELWLGRNTGNPNF-VYNIQIIF 514 Toxoplasma gondii VEG
Q5CYY5           411 AFLIRPIWILENSLDSNF-YYFLTLAG 436 Cryptosporidium parvum
Q22672           357 MPVMWHMWIVSSSGNANF-FFGTTIVY 382 Caenorhabditis elegans
XP_002639921     355 MPVMWHMWMVSSSGNANF-FFGATIVY 380 Caenorhabditis briggsae
jgi:MICPUN_60372 381 SPIMWRLWIVDRVANANF-FFATTLAW 406 Micromonas commoda
EEH56751         406 SPIFWRLWIVDRVANANF-FYAVTLTY 431 Micromonas pusilla CCMP1545
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