Conserved Protein Domain Family
SARAF

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pfam06682: SARAF 
SOCE-associated regulatory factor of calcium homoeostasis
SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.
Statistics
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PSSM-Id: 429068
Aligned: 45 rows
Threshold Bit Score: -1
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGF82781      18 LLFLVCILAPTATAAShKKVRLTNIQALTLHAGRMTTARRSSPVKQLSCVnsgnsgffSsskSACSDtallPQTVQCINK 97  Batrachochytriu...
XP_015199412   7 IFVLFIYTGRTESWNDgGSVLLRELQVITLYKGQYTNSRRTSPVPQLQCIg-------GtagCGSFI----PEVVQCHNK 75  spotted gar
XP_006010005   8 LFVLSLMLGPADGWNShESVLLQEVQVLTLYKNRFTTARRTSPVPQLQCNg-------GtagCSAFV----SEVVQCQNK 76  coelacanth
F7C1E2        14 PLLALLQIPGAWCWNHqERVLLRDIQAITLYADRYTNARRSAPVPQLKCIg-------GsagCHTMV----PQVVQCHNR 82  tropical clawed...
1_pfamImport   1 FLLLCAAASTAWGWDQ-QGVLLRDVQVLTLHRGRYTTARRTAAVPQLQCTg-------GsagCSD-I----PEVVQCYNK 67 
XP_003772841  24 VLLLLPRPSPALAWDQsEKILLRDIQALTLHRDRFTTARRTAPIPQLQCLg-------GsagCPAHI----PEIVQCRNK 92  Tasmanian devil
2_pfamImport   1 GLLLLLIAGPALGWNDpNRILLRDIQALTLHYDRYTTSRRLNPIPQLRCIg-------GtagCDTYT----PKVIQCQNK 69 
XP_003797715  18 LLLLLLIAGPALGRNDpDRILLRDVKALTLHYDRYTTSRRLDPIPQLKCVg-------GtagCDAYT----PKVIQCQNK 86  small-eared galago
Q6AYN2        19 LLSFLLVAGPALCWKNpDRILLRDVEALTLYSDRYTTSRRLDPIPQLKCVg-------GtagCDAYT----PKVVQCQNK 87  Norway rat
Q08E24        18 LLLLLLVVGTAQCWDErDRILLRDIKALTLYYDRYTTSRRLEPIPQLKCVg-------GtagCDSYT----PKVIQCQNR 86  cattle
XP_015199412   7 IFVLFIYTGRTESWNDgGSVLLRELQVITLYKGQYTNSRRTSPVPQLQCIg-------GtagCGSFI----PEVVQCHNK 75  spotted gar
XP_006010005   8 LFVLSLMLGPADGWNShESVLLQEVQVLTLYKNRFTTARRTSPVPQLQCNg-------GtagCSAFV----SEVVQCQNK 76  coelacanth
F7C1E2        14 PLLALLQIPGAWCWNHqERVLLRDIQAITLYADRYTNARRSAPVPQLKCIg-------GsagCHTMV----PQVVQCHNR 82  tropical clawed...
1_pfamImport   1 FLLLCAAASTAWGWDQ-QGVLLRDVQVLTLHRGRYTTARRTAAVPQLQCTg-------GsagCSD-I----PEVVQCYNK 67 
XP_003772841  24 VLLLLPRPSPALAWDQsEKILLRDIQALTLHRDRFTTARRTAPIPQLQCLg-------GsagCPAHI----PEIVQCRNK 92  Tasmanian devil
2_pfamImport   1 GLLLLLIAGPALGWNDpNRILLRDIQALTLHYDRYTTSRRLNPIPQLRCIg-------GtagCDTYT----PKVIQCQNK 69 
XP_003797715  18 LLLLLLIAGPALGRNDpDRILLRDVKALTLHYDRYTTSRRLDPIPQLKCVg-------GtagCDAYT----PKVIQCQNK 86  small-eared galago
Q6AYN2        19 LLSFLLVAGPALCWKNpDRILLRDVEALTLYSDRYTTSRRLDPIPQLKCVg-------GtagCDAYT----PKVVQCQNK 87  Norway rat
Q08E24        18 LLLLLLVVGTAQCWDErDRILLRDIKALTLYYDRYTTSRRLEPIPQLKCVg-------GtagCDSYT----PKVIQCQNR 86  cattle
EGF82781      98 GTDGVDVQWACTAELDSTVKFGSeMVVACEGWAYPEDPFVLAGSCGLEYTLVRTALYDRTRPSKEHHRFGEKWkpswsfw 177 Batrachochytriu...
XP_015199412  76 GWDGFDVQWECKTDMDYSYRFGK-IEVSCEGYNYPDDPYVLKGSCGLEYTLELTEEGKQKGRNSRSfgsgffqd------ 148 spotted gar
XP_006010005  77 GWDGFDVQWECKTDMDNNYRFGT-IQVNCEGYNSPDDPYVLKGSCGLEYTLELTEAGRMKRNKGYGSGGfssnffkd--- 152 coelacanth
F7C1E2        83 GWDGFDVQWECKVDMDNSYRFGK-VEVSCEGFDYPEDPYVLRGSCGLEYTLELTEEGRKRSQDGYRSGGfgsgyfqs--- 158 tropical clawed...
1_pfamImport  68 GWDGYDVQWQCKADLENTLRFGQ-IEVSCEGYNYPDDPYILRGSCSLLFRLELTKEGERKAKNFGGfgsgy--------- 137
XP_003772841  93 GWDGFDVQWECKAELDTSYRFGK-TAVSCEGYDYPDDPYVLRGSCGLEFNLELTEQGRKKYKDAGSSNTNSHGntygsny 171 Tasmanian devil
2_pfamImport  70 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYDLDYTELGLKKLRESGKNNgfnpfs------ 142
XP_003797715  87 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKFKESGKHHsfaafsdy---- 161 small-eared galago
Q6AYN2        88 GWDGYDVQWECKTDLDIAYKFGK-TVVSCEGYDSSEDQYILRGSCGLEYNLDYTELGLSKLKESGKHQsfsdyy------ 160 Norway rat
Q08E24        87 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYQLDYTELGLKKLRESGKEHgfnsfsny---- 161 cattle
XP_015199412  76 GWDGFDVQWECKTDMDYSYRFGK-IEVSCEGYNYPDDPYVLKGSCGLEYTLELTEEGKQKGRNSRSfgsgffqd------ 148 spotted gar
XP_006010005  77 GWDGFDVQWECKTDMDNNYRFGT-IQVNCEGYNSPDDPYVLKGSCGLEYTLELTEAGRMKRNKGYGSGGfssnffkd--- 152 coelacanth
F7C1E2        83 GWDGFDVQWECKVDMDNSYRFGK-VEVSCEGFDYPEDPYVLRGSCGLEYTLELTEEGRKRSQDGYRSGGfgsgyfqs--- 158 tropical clawed...
1_pfamImport  68 GWDGYDVQWQCKADLENTLRFGQ-IEVSCEGYNYPDDPYILRGSCSLLFRLELTKEGERKAKNFGGfgsgy--------- 137
XP_003772841  93 GWDGFDVQWECKAELDTSYRFGK-TAVSCEGYDYPDDPYVLRGSCGLEFNLELTEQGRKKYKDAGSSNTNSHGntygsny 171 Tasmanian devil
2_pfamImport  70 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYDLDYTELGLKKLRESGKNNgfnpfs------ 142
XP_003797715  87 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKFKESGKHHsfaafsdy---- 161 small-eared galago
Q6AYN2        88 GWDGYDVQWECKTDLDIAYKFGK-TVVSCEGYDSSEDQYILRGSCGLEYNLDYTELGLSKLKESGKHQsfsdyy------ 160 Norway rat
Q08E24        87 GWDGYDVQWECKTDLDVAYKFGK-TVVSCEGYESSEDQYVLRGSCGLEYQLDYTELGLKKLRESGKEHgfnsfsny---- 161 cattle
EGF82781     178 kskehyytentDGSSWIGFIIWTAVFAFIAYRISLACCskprrqgnhrtteTRGTFHSTAHAGtsf--------dpnSGP 249 Batrachochytriu...
XP_015199412 149 ---sssnvnyqGSGGDVSGLMVVAVLLLLAYGVYKMFLcgp--------hgQGHQRFPDAdfsnantd-ghftdgntMGP 216 spotted gar
XP_006010005 153 ---fsnnvnspVSSDSSGVL-VVVILLVIAYGIYKIFLss----------pQSEQPFPGSTGDfntdrqnyyssshsMGP 218 coelacanth
F7C1E2       159 ---nsnswdtkTNGSSA---IVLIVIVIIAYGVYKLFLsg---------psVQEHPRPDEYGYdfqs------qtraSAP 217 tropical clawed...
1_pfamImport 138 ------ytsskDSSHSGTGAIFVIVLLILAFGVYKFFLsn----------qQPQQSFGDGGGDgftrpf----wqshqAP 197
XP_003772841 172 fpgyvekmdspVPS-STRGLLAVVILLVLALGVYKLFLkaqned--lpppyTEHPQDhqrff----------qasppPPP 238 Tasmanian devil
2_pfamImport 143 ------dyyksNSS-GISGLITIVVLLAIAFGVYKLFLgggqd---spppySESPPYspgfq----------gftnsAGP 202
XP_003797715 162 ----ynkwysaDAC-STGGLITIVVLLTIAFAVYKLFLsdgqc---spppySEYPPFshhyq----------rftnsAGP 223 small-eared galago
Q6AYN2       161 -----hklssvDSC----GLVTVAVLFVLAFVVYKLFLsdgqg---spppySEHPPYsqhsq----------rfagtAGA 218 Norway rat
Q08E24       162 ----ysklyspESS-SLGGVVTIVVLLAIAFGVYKFFLsdghe---spppySEDPPYshryq----------rfsssAGP 223 cattle
XP_015199412 149 ---sssnvnyqGSGGDVSGLMVVAVLLLLAYGVYKMFLcgp--------hgQGHQRFPDAdfsnantd-ghftdgntMGP 216 spotted gar
XP_006010005 153 ---fsnnvnspVSSDSSGVL-VVVILLVIAYGIYKIFLss----------pQSEQPFPGSTGDfntdrqnyyssshsMGP 218 coelacanth
F7C1E2       159 ---nsnswdtkTNGSSA---IVLIVIVIIAYGVYKLFLsg---------psVQEHPRPDEYGYdfqs------qtraSAP 217 tropical clawed...
1_pfamImport 138 ------ytsskDSSHSGTGAIFVIVLLILAFGVYKFFLsn----------qQPQQSFGDGGGDgftrpf----wqshqAP 197
XP_003772841 172 fpgyvekmdspVPS-STRGLLAVVILLVLALGVYKLFLkaqned--lpppyTEHPQDhqrff----------qasppPPP 238 Tasmanian devil
2_pfamImport 143 ------dyyksNSS-GISGLITIVVLLAIAFGVYKLFLgggqd---spppySESPPYspgfq----------gftnsAGP 202
XP_003797715 162 ----ynkwysaDAC-STGGLITIVVLLTIAFAVYKLFLsdgqc---spppySEYPPFshhyq----------rftnsAGP 223 small-eared galago
Q6AYN2       161 -----hklssvDSC----GLVTVAVLFVLAFVVYKLFLsdgqg---spppySEHPPYsqhsq----------rfagtAGA 218 Norway rat
Q08E24       162 ----ysklyspESS-SLGGVVTIVVLLAIAFGVYKFFLsdghe---spppySEDPPYshryq----------rfsssAGP 223 cattle
EGF82781     250 PPPYndgwesqdnth---qhasaphpgaYpssgggnSQNSdGSRSNnDGFWSGFTSGSILGSLFGNRSYWYPSTNYfgyg 326 Batrachochytriu...
XP_015199412 217 PPPGfksyytgespgyesa-------rdsygfkntftrphqKPASG-PGFWTGMGTGGVLGYLFGSQR------------ 276 spotted gar
XP_006010005 219 SPPGfkpdfaghstdgegfsggfnfgnyD-------TRHRhNGNSG-PGFWTGLGTGGILGYMFGNQRSN--QSPY---- 284 coelacanth
F7C1E2       218 PPPGfksdftdphlckifg----------asksfssgygtshsNQG-PGFWTGLGTGGVLGYLFGNRRAQPYQAPY---- 282 tropical clawed...
1_pfamImport 198 PPPGfkfsstgneyhvai----------lgltrgllqsqshETNTG-PGFWTGLGAGGLLGYLAGSQRFV--VCEF---- 260
XP_003772841 239 PPPGfksyftasgtpg-------------wgfgnsftgpqaFGQSG-PGFWTGLGTGGLLGYLFGNNRA----TPL---- 296 Tasmanian devil
2_pfamImport 203 PPPGfkpgftgmfgtpga----------tygfgsaftgqqgNANSG-PGFWTGLGTGGILGYLFGSNRAT--TTPF---- 265
XP_003797715 224 PPAGfkseftgpqntgrg---------atsgfgsaftgqqgHENSG-PGFWTGLGTGGILGYLFGSNRA---ATPF---- 286 small-eared galago
Q6AYN2       219 PPPGfksdftgpqstsyg----------assgfgsafggqsyASSG-PGFWSGLGAGGLLGYLFGSNRA---ATPF---- 280 Norway rat
Q08E24       224 PPAGfkseftgphgat-------------agfgsaftgqqgHEHSG-PGFWTGLGTGGILGYLFGSNRA---ATPF---- 282 cattle
XP_015199412 217 PPPGfksyytgespgyesa-------rdsygfkntftrphqKPASG-PGFWTGMGTGGVLGYLFGSQR------------ 276 spotted gar
XP_006010005 219 SPPGfkpdfaghstdgegfsggfnfgnyD-------TRHRhNGNSG-PGFWTGLGTGGILGYMFGNQRSN--QSPY---- 284 coelacanth
F7C1E2       218 PPPGfksdftdphlckifg----------asksfssgygtshsNQG-PGFWTGLGTGGVLGYLFGNRRAQPYQAPY---- 282 tropical clawed...
1_pfamImport 198 PPPGfkfsstgneyhvai----------lgltrgllqsqshETNTG-PGFWTGLGAGGLLGYLAGSQRFV--VCEF---- 260
XP_003772841 239 PPPGfksyftasgtpg-------------wgfgnsftgpqaFGQSG-PGFWTGLGTGGLLGYLFGNNRA----TPL---- 296 Tasmanian devil
2_pfamImport 203 PPPGfkpgftgmfgtpga----------tygfgsaftgqqgNANSG-PGFWTGLGTGGILGYLFGSNRAT--TTPF---- 265
XP_003797715 224 PPAGfkseftgpqntgrg---------atsgfgsaftgqqgHENSG-PGFWTGLGTGGILGYLFGSNRA---ATPF---- 286 small-eared galago
Q6AYN2       219 PPPGfksdftgpqstsyg----------assgfgsafggqsyASSG-PGFWSGLGAGGLLGYLFGSNRA---ATPF---- 280 Norway rat
Q08E24       224 PPAGfkseftgphgat-------------agfgsaftgqqgHEHSG-PGFWTGLGTGGILGYLFGSNRA---ATPF---- 282 cattle
EGF82781     327 pqaypsytfypprptswwswGSGWPQSTy-----T------YSnpmfrrtssssgsrsqspaPSTRTSTTYGGTRRR 392 Batrachochytrium d...
XP_015199412 277 -----------------------------------------SQpryftrntgnsnigptpvnSGTRTVSGFGGTKRR 312 spotted gar
XP_006010005 285 --------------------TNIWGNPAypp-pmHgypsan---------------rgvsesTGTRTASGFGGTKRR 325 coelacanth
F7C1E2       283 --------------------FNTWTGPSn-----Sdsmhqn---------------yrppqsSGVRTASGFGGTKRR 319 tropical clawed frog
1_pfamImport 261 --------------------SDSWSQKTqprssyFdtwgdpTAvppvyrq-----ssnstqgSSTRTASGFGGTKRR 312
XP_003772841 297 --------------------SNNWTHPAypp-pyFntwnnpVppsapvnsr--ssgsssgsdTGTRTTSGFAATKRR 350 Tasmanian devil
2_pfamImport 266 --------------------SDSWYRPSyp--syFgtgnsrASsphcgdsgn--ysacsssqTKTRTASGYGGTKRR 318
XP_003797715 287 --------------------SDSWYYPAcpp-pySgtwngrASsplrgssgg--ysacanaeTKTRTASGYGGTRRR 340 small-eared galago
Q6AYN2       281 --------------------SGSWYHPSyps-syAgawnshAYsplgggagr--ysassnteSRTRTTSGYGGTRRR 334 Norway rat
Q08E24       283 --------------------SDSWY-PSypp-syTstwnsrAYsplrggpgs--ssacsgsePRTRTASGYGGTRRR 335 cattle
XP_015199412 277 -----------------------------------------SQpryftrntgnsnigptpvnSGTRTVSGFGGTKRR 312 spotted gar
XP_006010005 285 --------------------TNIWGNPAypp-pmHgypsan---------------rgvsesTGTRTASGFGGTKRR 325 coelacanth
F7C1E2       283 --------------------FNTWTGPSn-----Sdsmhqn---------------yrppqsSGVRTASGFGGTKRR 319 tropical clawed frog
1_pfamImport 261 --------------------SDSWSQKTqprssyFdtwgdpTAvppvyrq-----ssnstqgSSTRTASGFGGTKRR 312
XP_003772841 297 --------------------SNNWTHPAypp-pyFntwnnpVppsapvnsr--ssgsssgsdTGTRTTSGFAATKRR 350 Tasmanian devil
2_pfamImport 266 --------------------SDSWYRPSyp--syFgtgnsrASsphcgdsgn--ysacsssqTKTRTASGYGGTKRR 318
XP_003797715 287 --------------------SDSWYYPAcpp-pySgtwngrASsplrgssgg--ysacanaeTKTRTASGYGGTRRR 340 small-eared galago
Q6AYN2       281 --------------------SGSWYHPSyps-syAgawnshAYsplgggagr--ysassnteSRTRTTSGYGGTRRR 334 Norway rat
Q08E24       283 --------------------SDSWY-PSypp-syTstwnsrAYsplrggpgs--ssacsgsePRTRTASGYGGTRRR 335 cattle
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