Conserved Protein Domain Family
ITI_HC_C
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pfam06668: ITI_HC_C 
Inter-alpha-trypsin inhibitor heavy chain C-terminus
This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.
Links
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Statistics
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PSSM-Id: 399571
Aligned: 59 rows
Threshold Bit Score: 140.026
Threshold Setting Gi: 405957680
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_022527107  760 HSGVTVNGKLIGAPApAGSHKQQRTYFSSIIVVVd---RPRRSYIEVTPRKVIL--DGRDRMILPCSSSIAVESDSLGVA 834  Mexican tetra
EKC23874      678 KSGLFVNAGIIPSFE-FDRHGKMKTFMGEIIILY------KSHVMKITPSEIIY--DGAH---LFWQDNLPYDFDDVKVE 745  Pacific oyster
XP_009859948 1375 VNGISVNGKLAQTPV-HISETDSPTFISDLGISL----ANQGINIQIDSFTLVIriRGGRPQQFSLKKMFRIKRRGVWFE 1449 vase tunicate
4_pfamImport    1 TQNLTVNGDIVAVAApPGSMKPNRTYISNLYIHI----PQQKFKIIVRPYNVTFipVGAQPFTVPVTTPIRFNGKGIRFQ 76  
EGW02319      786 KAGLHVSGKLLGAPPrPGHEDQTRTYFQIITITSd---KPWAYTVTIGLSSISV--QGEGTLNLPWDQPALVKKPQLELH 860  Chinese hamster
XP_008120881  974 ITGLSVNGHLMGAPLrPGHEERPRTYFDAITIVVgellPLPGYVINITRKGITL--HGEHILVLPFTQRATIHKPQLVIS 1051 green anole
XP_007667881 1126 TAGLRVNGHLVGAPPkVGHEDRSRTYFDMISVVVq--yPRVSYALNITRDSISL--KGEDSLVVPWSRPAFIQKPRLALK 1201 platypus
XP_003439089  987 ERNIIVDGHLMGAPSkDGAEDRLRNYFDQLTISVvt-gNSGDIMITLTLDAVVV--EGEGRDTLPINQQGSVTRQGVTVT 1063 Nile tilapia
XP_006005468  961 QSGVEVTGHLLGAPPkTAHENFLRNYFDLITITVr--rPAGNYLINVTMRNVTV--QGEGLHTLSCYRTASLHLPGLTLS 1036 coelacanth
KAE8583273    667 IAGITVNGHLMKAPLkVGFESRIRTYLDVITVVId--rPRSKYVVSISLQNLTL--TGEKQQTFAISLPVFLQKPSLAIR 742  tropical claw...

XP_022527107  835 IVANA----NITVTIQ---GTIQFIILLHNYKNPAPYQRDHLGFYI-AKSGGLSKSTHGLLGQFLYE-EVGLTEVPGNvt 905  Mexican tetra
EKC23874      746 IITVSgf-rVMNVDFR---NNVQIAIKKTNASRFHNSSVEYLNMYI-ENEAGLSKASDGILGQFLHR-YISVYKQRSNkk 819  Pacific oyster
XP_009859948 1450 NQPISytryELMIKLP---QDIQFQIVSH-VHAPNANIINHLDFSI-VRSSGLSNATSGVLGQFPHNsEIAPATID---- 1520 vase tunicate
4_pfamImport   77 VHGIT----HTRARIDviiDGLNFQVVLH-RNNRHLYSTDHLDFSVrSSGSKLGRGVDGVIGQFLNShVIVLN------- 144 
EGW02319      861 VASAA----HLTLQLG---PHLNFLILRHQYRHPSTLQLPHLGFYV-ASDSGLSPSARGLMGQFQHT-DIRLVTGPTG-- 929  Chinese hamster
XP_008120881 1052 MWPEA----NVTVQIG---HELEFLVLLHRYSHPTALQLDHLGFYM-VNGKGLSPSACGLLGQFQNS-GIQLSSGAVD-- 1120 green anole
XP_007667881 1202 VSPSA----NVTLWIG---TDIEFLILLHRYSHPTYLQLAHLGFYI-VNGKGLSSSAQGLLGQFQHA-DIQVNREQGT-- 1270 platypus
XP_003439089 1064 VDNHQ----SCWIELA---EGVQFLVLFHHYKHPSYLQSAHLGFYI-TDGRGLSDSTQGLLGQFQHA-DINITVVKDHvd 1134 Nile tilapia
XP_006005468 1037 VSHRA----NVSIQIG---NSLDFLVLLHHFHHPTYLQLDHVGFYV-VNGKGFSPSAHGILDQFLYA-DINVTRTAGDvt 1107 coelacanth
KAE8583273    743 VVPST----NVTIWIG---RNVELLIIFHHYQHPSYLQLDHLGFYI-VNAEGLSSSSGGLLGQFQNC-HMEVTNQKLS-- 811  tropical claw...

XP_022527107  906 vakgnstqeanataGPPESGLKVLKVKERIVNVVkksrriysgt----qtvdcwfakN 959  Mexican tetra
EKC23874      820 dqivgh-lqikepgFDTTRMRAVLVKKPDEITAKrepc---------------wnihS 861  Pacific oyster
XP_009859948 1521 --------------FIPNTQHALLWFRHSMVKVTnhimydsltk----rtiecwwvkN 1560 vase tunicate
4_pfamImport  145 --------------GDAEEKEAFILIDEQLGQVTrtkkklptdr----gmiecwfarN 184 
EGW02319      930 --------------------SYLQKHRGPGVPVVlgkkllkesprlhprwtscwlvkR 967  Chinese hamster
XP_008120881 1121 -----------------GEPATWLWRGASKIPVTevtkilkdspq-raheapcwlvkR 1160 green anole
XP_007667881 1271 -----------------RAQTGVLRSEAATLPVVwvekllkdsal-qphkthcwlvkR 1310 platypus
XP_003439089 1135 egl-------hrvrKEEILARGILRWGSEQMPVTlqdktlkdsvq-krhrgscwvvpK 1184 Nile tilapia
XP_006005468 1108 qe---------tcpDCRRPVTGVLRISGWNIPVTlvtknikdsyl-kphegpcwqvgK 1155 coelacanth
KAE8583273    812 ---------------HDLTLSGTVIRNKQTAPTTlvektvkdsta-qvhvakcwlvkH 853  tropical clawed frog
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