7KC4


Conserved Protein Domain Family
MIG-14_Wnt-bd

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pfam06664: MIG-14_Wnt-bd 
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Wnt-binding factor required for Wnt secretion
MIG-14 is a Wnt-binding factor. Newly synthesized EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion.
Statistics
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PSSM-Id: 429058
Aligned: 59 rows
Threshold Bit Score: 123.518
Threshold Setting Gi: 169802181
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KC4_B       178 ECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIgeiKD--IRLVGIHQNGGFTKVWFAMKT--FLTPSIFIIMVWy- 252
EFC46545     192 LCDPITLFYESHIRHPYYRIGVSFLNSRELYDNTLI---DPhfVKMEFESYNAAYSNWELGWRYsiIFITAPLCIAFIia 268 Naegleria gruberi
EFC48451     151 FCAPVIVYRERYISYPTYRIKVQIENL----DVSSLl--RSdtLFYRLETIRSDFTTFESVMRY--LYAAISIIIFIFys 222 Naegleria gruberi
Q5EHP7       162 KCDIGYISSELYLDYPIYIIEISII--NENV-KDIV---SD--LIFKASFVSTFYTIFELFWRL--IFILFSCLCTCIyl 231 Entamoeba histo...
XP_650991    164 DCKAIPLASQIYLTHPNYLLEFTFTPTDI----------SLgdIIVENSYISTSYSVFEMFWRM--AFILFSSFCCMLyl 231 Entamoeba histo...
XP_650477    188 NCNKFTFFKYKLLIYEYYNITMSISHT-----TFDSn--QLgdLILSLRTVNHKYNFYEIGWRF--VFIILSCIVMGLft 258 Entamoeba histo...
XP_655860    181 YCNSLPIYEESFTNKLEYLITIQFI--SSKFNETDV---GE--FVLELSAISSHYTLFELCWKF--VFIFYSCIIVVIyl 251 Entamoeba histo...
EAY20131     155 LTTSITLFTDIILDYNKVEIDLTFDHP-----YTHF---SS--FILTYSIGTPDHAYFQIYFRF--LFSIVSAIFLALml 222 Trichomonas vag...
XP_001309127 155 ETYPIILYTQKLLNFDSIHFECTIDVP------PMY---TS--LTLRFVHGFTQYTIFQIYFKL--IFALIELIFLVLfv 221 Trichomonas vag...
XP_001320784 147 TSDQILLYSSPLIEYDAIRIDIVVTDA------EHL---RA--AQVSHYLATIQHSYYEIYFRT--AFAIIEFMLLILfv 213 Trichomonas vag...
7KC4_B       253 --WRRiTMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMmdQHErN 330
EFC46545     269 -nIIR-SH-FVNWATEQKWIGLLLIFLVLYNNPIFALIFTAGNWAFSFINIVFIISFVCFLMFVVLVFTDSLVipQKDrS 345 Naegleria gruberi
EFC48451     223 fiLLK-YQTFRYAKTEQKWILFLLISLILFNNPLFIGEWLANDWILPFLNIIFQSTFISFFLLFLMVITASANthPKLr- 300 Naegleria gruberi
Q5EHP7       232 -wANR-SIPQEKWSHEQKWTVVLLTFLIWENNPLYPYEFLMDNAFYLFVNSVIDTIFICFLMFYVLIMFDALRkpIRQrT 309 Entamoeba histo...
XP_650991    232 -sSIR-GIPISQWCHEQKWTFILNIVLILFNNPFFFYEYIVDSVTFLLFNTGIETFFICFLMFYVLSMFEALRkpLNIrK 309 Entamoeba histo...
XP_650477    259 -fVSR-KYVYRNWPVENKLTFLLLFVLILFNNPFFTYEYVFASSLFVFWKIIITSIFCVFVVFYVLVIFEALRkpISWrK 336 Entamoeba histo...
XP_655860    252 -fIFR-SFIFKTWIFEVKWTFVLLIILVIQNNPIYSYQYTLDTFIPEFINVTVYSLFYVFLLFYVLITFEFYRygKGTkK 329 Entamoeba histo...
EAY20131     223 -yFLR-GLEVKLWHLEQKLTVPLVALLIFYNNPFYIFHVYNPSPVFVILDRILDSIFHSYMCFFILVLFDSLRy-KNRkT 299 Trichomonas vag...
XP_001309127 222 -lRLS-TAQFKYWHLEQKLTCPLLLLSFLYNNIFEFFFVKHKSNSVVLLEILVNSLFSAYLKFFILVLFDSLRy-KNRkT 298 Trichomonas vag...
XP_001320784 214 -fSLR-KVSYSFWHLEQKLTLHLQFLSMLFNNPLIYLTITYPSKTGLILDILIKSIFTTYFRYFVLVLFDSLRy-KNRkT 290 Trichomonas vag...
7KC4_B       331 HIAGYWKQVGPI----AVGSFCLFIFD--------MCERGVQLTNPFYSIWttdigtelAM---------AFIIVAGICL 389
EFC46545     346 FLWFYIPKIVLV----GILFVFVITTF--------TYVRLQEQEDPGYNLGi------vQGlss----yqTLGIIVVLIM 403 Naegleria gruberi
EFC48451     301 TVNFYIWKSIFT----LLFWCCLTVSL--------LFERYETFSDRLM-----------YSylidaplfgIIRIGVIGLG 357 Naegleria gruberi
Q5EHP7       310 SIRFYLPRGLLC----GLLFSLILASF--------MYNKTRKIYSPTMTGshdv-------------fnvIISLGIMGLL 364 Entamoeba histo...
XP_650991    310 SFRFILPRALLL----LTLFMLVFTEL--------MYNRTTPNYSITLKGiddp-------------anvVLSILILGII 364 Entamoeba histo...
XP_650477    337 NINFWIGRILFF----CAFILVILITL--------LYNTTYSITDINYKPlkdi-------------pniVFCVADIIFA 391 Entamoeba histo...
XP_655860    330 -IKYWLPRIIFF----VFFFAAVELVF--------IYNKSVGLSDPYYNPlkdi-------------aslVMAVIALVFV 383 Entamoeba histo...
EAY20131     300 DRCFYIPKIIMC----SIILIVYSIHG--------IYDKLHLIAEHNKNYN-------------------TTAITSVAEM 348 Trichomonas vag...
XP_001309127 299 DKCFFVPKIILC----SIIYLADVVSEig----ftVFDK-------------------------------KIIFMAYFNI 339 Trichomonas vag...
XP_001320784 291 DPCFFVPKILFSfamfATIYLNTMITElpsylpfeLSDE-------------------------------VKKYIDTADT 339 Trichomonas vag...
7KC4_B       390 CLYFLFLCFMVFQ---------------------------------VFRNISGkqSSlpamskvrrlhyEGLIfRFKFlm 436
EFC46545     404 LVYIFVLIYYLMR---------------------------------VIEKHRMnlLP------------KRNAwRSKViw 438 Naegleria gruberi
EFC48451     358 GLMLLYIFYQIFKtlggndfiqlaenlnntqplnqelkdklamniiSYSNTNQssV------------------RFKYff 419 Naegleria gruberi
Q5EHP7       365 IIYLFWLIFSIIR---------------------------------SFSEVRK--LG------------SAGY-RVQV-- 394 Entamoeba histo...
XP_650991    365 VIYIFWLVFGIIR---------------------------------TYSESRK--LG------------PVSL-RLKY-- 394 Entamoeba histo...
XP_650477    392 VIYFIWLCFSVIR---------------------------------SFSEAKRv-------------------gNTKRiy 419 Entamoeba histo...
XP_655860    384 IAYIFWLIYILVR---------------------------------SFSDGIK--LG------------KTKR-KLRL-- 413 Entamoeba histo...
EAY20131     349 VVYLTFLLYTILS---------------------------------ILISASRvdVT------------E----RYKFni 379 Trichomonas vag...
XP_001309127 340 VLFCGYIVWCIFC---------------------------------IIVASIQvdIT------------E----RYKYii 370 Trichomonas vag...
XP_001320784 340 ALFGVYLVWAAIT---------------------------------TLFAGCQvdIT------------E----RYKYvi 370 Trichomonas vag...
7KC4_B       437 lITLACAAMTVIFFIVSQVTEghwkwggvtvqvnSAFFTGIYGMWNLYVFALMFLYAPSH 496
EFC46545     439 fLTITMVIGTIVEIFLYVfskd---------wnsSAQFLSYFMFYSLYVWLITILYWPSF 489 Naegleria gruberi
EFC48451     420 iLTFLVLVVLGANMFSFLilnt---------sdnAVQYLGVFPLLNFYCIMLAIYFLPSL 470 Naegleria gruberi
Q5EHP7       395 -YGIFTIFILLFYVSLLLSVFfmgy------rnnAAVSLTTIAFVNFYCMVLTILYLPSN 447 Entamoeba histolytica
XP_650991    395 -YGGFTICVIILYLCLLIAANfmgy------hnnASITLTTLAYVNLYVMTLTILYLPVE 447 Entamoeba histolytica HM-1:IMSS
XP_650477    420 tFGILVITSVIIFVLLLVVAFflgf------ensATTYLSTLSYGNLFIWLLSIFYIPKP 473 Entamoeba histolytica HM-1:IMSS
XP_655860    414 -FGVLTMISMMLFFMMLALSFffgn------qqtLSISLTTTAFVNFFCTLLIVINIPHQ 466 Entamoeba histolytica HM-1:IMSS
EAY20131     380 yLSSGLIAVIIMGACQALSSFklf-------sesSLSFVIKFAVENIFSFLMVYFHWPYE 432 Trichomonas vaginalis G3
XP_001309127 371 yLVSGSVSIALIFLYGVIFSFlpkf------kdsALRFVGVYSIQNVFVLLMAYFHWPYE 424 Trichomonas vaginalis G3
XP_001320784 371 yIISGIAALALLATSELLFKFfkff------qdsSLQFVEQFSIYNVFSMLMVYFHWPFE 424 Trichomonas vaginalis G3
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