1FJR


Conserved Protein Domain Family
Methuselah_N

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pfam06652: Methuselah_N 
Methuselah N-terminus
This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. This family is found in conjunction with pfam00002.
Statistics
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PSSM-Id: 399562
View PSSM: pfam06652
Aligned: 33 rows
Threshold Bit Score: 196.694
Threshold Setting Gi: 29337243
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1FJR_A                5 CDYFDTVDISAAQKLQN------GSYLFEGLLVPAILTGEYDFrILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMD 78 
Q9W0R6               29 CAYAHTVNITDGLRMKD------GSYSYAGVVVPPHLMAEYSF-KVIDGVEYRAKKHLRGCVCLLKPCISFCCPENLVFD 101 fruit fly
XP_001955866         29 CAYANTVNITDGLRLKD------GSYSYAGLVIPPNMIAEYSF-KVIDGVQYRAKKHLRGCACLQKACISFCCPPDLVFD 101 Drosophi...
EDV95978             33 CPYADTVNITDGLRLRD------GSYSFAGVLVPAELTAEYNF-KVIDGVEYKAARHLRGCVCQIKPCITFCCPPDLVFN 105 Drosophi...
XP_002012034         31 CAYADTVNITDGLRLKD------GSYSYAGVLIPPELMAEYSF-KVIDGVEYRAEKHLRGCVCQLKPCITFCCPPDLVFN 103 Drosophi...
WGS:AAQB:GK21004-PA  40 CAFIDTTNISGSYAMDSsf---nGSYIHNWTVIPREWVAIYDF-VIEDGVRVPARRHLRGCVCKQTPCVRFCCPDGQIYD 115 Drosophi...
WGS:AANI:GJ12496-PA  32 CAFIDTANITGGYNMGNlggslnGSYVYNWTVIPKELVTAYDF-VIENGIRVPAARHLRACVCKLRPCVRFCCPAGQLYE 110 Drosophi...
XP_002012035         31 CAFIDTVNITGSYNMGSsl---nNSYVHNWTVIPRELVTAYDF-IIENGIRVPAKRHLRACICKLRPCVRFCCPAGQFYD 106 Drosophi...
NP_001261182         30 CAFIDTANITGSYGLD-------GPFVHNWTVIPRHFVAVYDF-VIENGIRIPASRHLRACVCKTKPCVRICCLRGEIYD 101 fruit fly
WGS:AAPP:GF24878-PA  29 CAFIDTANITDTPGRVGd----nATYFYNWTPIPHHLVAVYDF-VIDNGIRIPARKHLRACVCRLKPCVRICCPSGHLYD 103 Drosophi...
1FJR_A               79 NG--VCYDNm---SdEELAELD-PFLNVTLD-DGSVSRRHFKNELIVQWDLPmpCDGMFYLDNREEQDKYTLFENGTFFR 151
Q9W0R6              102 AKhwNCTMPhqvrEs--------THVELTYA-NRTVDQVRIRDRFVVRTELG--CRNKFVDKKHDNFWQWDLFENGTLRR 170 fruit fly
XP_001955866        102 SKhwNCSQPhqirEs--------THIELTYG-NRSVENVRIKDRFLVRTELG--CRNKFVDRKHESFWKWDLFENGSLFR 170 Drosophi...
EDV95978            106 AQrwNCTRPnqvrQi--------THIELSASgNRSVEQVKIMDHFVVRTELG--CRNKFVDSNHDSFWQWDLHANGSLQR 175 Drosophi...
XP_002012034        104 AEswNCTKPkqerLi--------SHVELTYA-NLSVAQVKISEHFVVRTELG--CRNKFVDKKHDTFWQWDLHENGSLLR 172 Drosophi...
WGS:AAQB:GK21004-PA 116 LNekQCRQPhs-mS-VNNLPPDhSHMDIELN-NGSLRHIELRSLYSIHVETP--CKHMKALRKNMEYVHWTLHENGTITH 190 Drosophi...
WGS:AANI:GJ12496-PA 111 LQrrRCVAPt---G-DGPQPPGhSHMTVELH-NGSRLSIELRARFSVHVETP--CDHMRALTKDSVYLNWTLHENGSITH 183 Drosophi...
XP_002012035        107 LEerSCLAAq---E-QLPPPPGqSHMAVQLH-NGTQLDIELRSLFSVYEETP--CDHMKAYTKDNTYLNWTLHENGSIIH 179 Drosophi...
NP_001261182        102 LEkrQCLVPv---A-GVSSLPShSHMEVELG-NGSLRLVKLQPRFSIHVETP--CEHMKAVTKGSEYVHWTLHENGTISH 174 fruit fly
WGS:AAPP:GF24878-PA 104 ADtrQCSVPr---S-GLPPLPAhSHMEVELL-NGSLRRLELGPAFSIHIDTP--CKHMKPVTKGAEYVHWTLHENGTVSH 176 Drosophi...
1FJR_A              152 HfdRVTLRKREYCLQHLTFADGnatSIRIAPHNC 185
Q9W0R6              171 D--NRLWSTDEYCFSPLEHNPE---QWELTPLNC 199 fruit fly
XP_001955866        171 E--NRVWSTDEYCFSPLEHKPE---QWELAPISC 199 Drosophila ananassae
EDV95978            176 D--DRLWSTDEYCFTPLEHN-S---AWELAPLNC 203 Drosophila grimshawi
XP_002012034        173 D--GRLWSTDEYCFTPLEHK-D---AWQLTPLNC 200 Drosophila mojavensis
WGS:AAQB:GK21004-PA 191 ---RGHMFTKHYCFTPLQLANA---SWDWQPLAC 218 Drosophila willistoni
WGS:AANI:GJ12496-PA 184 ---REHLFTKHYCFTPLRVGNS---SWNWQPLAC 211 Drosophila virilis
XP_002012035        180 ---RDYLFSKHYCFSPLLIGNS---SWSWQPLAC 207 Drosophila mojavensis
NP_001261182        175 ---RGHIFSKHYCFTPLLHGNS---TWEWQPLAC 202 fruit fly
WGS:AAPP:GF24878-PA 177 ---RGHVFSKHYCFTPLLLGNS---TWDWQPLAC 204 Drosophila ananassae
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