Conserved Protein Domain Family
SIM_C

?
pfam06621: SIM_C 
Single-minded protein C-terminus
This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologs in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerization partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism. SIM2 is thought to contribute to some specific Down syndrome phenotypes. This family is found in conjunction with a pfam00989 domain and associated pfam00785 motif.
Statistics
?
PSSM-Id: 399545
View PSSM: pfam06621
Aligned: 16 rows
Threshold Bit Score: 254.032
Threshold Setting Gi: 1191831105
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015205072 359 STPTITDSRKPSKSRVARTKSKARASPY-P-QYSGFHTERSESDHESQWGGSPLTDSASPQlldhgegphsqhpdvscAY 436 spotted gar
XP_003763442 359 SMSTSQEPRKIAKYKSNKMKTKVRTNPYlPqQYDSFQMDKSECGQVGNWRASSATNPTNTQ-----------------EQ 421 Tasmanian devil
XP_020926626 359 ALSTSQETRKLAKPKNTKMKTKLRTNPYpPqQYSSFQMDKLDCGQLGSWRASPPASAPAPP-----------------EQ 421 pig
Q61079       359 TLSTSQETRKSAKPKNTKMKTKLRTNPYpPqQYSSFQMDKLECSQVGNWRTSPPTNAVAPP-----------------EQ 421 house mouse
7_pfamImport   2 SMSTSQEPRKIAKYKSNKMKTKVRTNPYlPqQYDSFQMDKSECGQVGNWRASSATNPTNTQ-----------------EQ 64 
XP_003454910 357 STSSLTDNCRTPKSRASRPKTRARLSPY-T-QYSSFQTERSESGQDSPWGSSPLTDSASPRlleqpe-----gvdascVY 429 Nile tilapia
Q98SJ5       359 PSNPVTENRRVGKSRVSRTKTKTRLSPY-S-QYPGFPTDRSESDQDSPWGGSPLTDSASPQlleqce-----giesscVY 431 zebrafish
XP_023187120 359 iTNSLPENCKTLKSRVMRPKTKSRLSPY-T-QYPSFNT---ESDLDSPWGSSPLTDSASPQlsehm--------easySC 425 southern platyfish
XP_031134248 359 TASSLTENCRTPKSRVSRPKTKARLSPY-T-QYPSFQTERSESDQDSPWGSSPLTDSASPQlleqse-----gldascVY 431 pike-perch
XP_023414856 359 TLSTSQETRKLAKPKNTKVKTKLRTNPYpPqQYSSFQMNKLDCSQLGPWRTSPTVTTPAPP-----------------EQ 421 African savanna...
XP_015205072 437 RQYSDRSSLCY--GFTLDHAAR--LS----------EERHSHYHSQA--CdGGRCEAGRYFLGTPQPARESWWSTSRSLL 500 spotted gar
XP_003763442 422 NFYSENSELLYapSYSLPFSYH--YGpfpidshvfrSKRQMLSSKFGqsQ-GSPCEVAHFFLSTLQTSGECQWHYTNPLV 498 Tasmanian devil
XP_020926626 422 QLHSEGGDLLYapSYSLPFSYH--YGhfpldshvfsSKKPMLPAKFGqpP-GSPCEVARFLLSTLPAGSECQWHYANPLV 498 pig
Q61079       422 QLHSEASDLLYgpPYSLPFSYH--YGhfpldshvfsSKKPGLPAKFGqpQ-GSPCEVARFFLSTLPASSECQWHCANSLV 498 house mouse
7_pfamImport  65 NFYSENSELLYapSYSLPFSYH--YGpfpidshvfrSKRQMLSSKFGqsQ-GSPCEVAHFFLSTLQTSGECQWHYTNPLV 141
XP_003454910 430 RQFSDPRTLCY--NLSEDQIT---------------SHTHIHIHGQGqsCeRGRCEAGRYFLGAPPPGRETWWDTARSVI 492 Nile tilapia
Q98SJ5       432 RQFSDPRSLCY--GLPLTEDHH--TS----------NELYSHPHSES--CeRGCCKAGRYFLGTPQPGREAWWGAARSVL 495 zebrafish
XP_023187120 426 RNLSDPQSLCY--NLSEEQ-HH--TT----------SDI--HAHGQGqsCeRGRCDAGRYFLGAPPTSRDTWFSTAQSFI 488 southern platyfish
XP_031134248 432 RQFPDPRPRCY--SLSDEH-HHttSD----------GYTHLHAHGQGqsCeRGRCEAGRYFLGAPSTGRDAWWGTARSVL 498 pike-perch
XP_023414856 422 QLHSESSDLLYapPYSLPFSYH--YGhfpldshvfsSKKPMLPSKFGqpQ-GSPCEVARFFLSTLPTGSECQWHYANPLV 498 African savanna...
XP_015205072 501 TVP----KSS----PEN----------REGFDNcmPH-----IAS------VH-S--------V--HVRGHWDEDSvvss 540 spotted gar
XP_003763442 499 PNSqspaKNH----PDQpmnit-rhnlAPNYEV--PI-----SAQ------RYnE--------D--IISDNFASCA---- 546 Tasmanian devil
XP_020926626 499 PSGpspaKSL----SQPpanta-rhslGPNYEAp-AA-----AAR------RFgE--------DtaPPPPSFPSCGhyre 553 pig
Q61079       499 PSSsspaKNL----SEPspvnaarhglVPNYEAp-SA-----AAR------RFcE--------D--PAPPSFPSCGhyre 552 house mouse
7_pfamImport 142 PNSqspaKNH----PDQpmnit-rhnlAPNYEVlpKG-----KIR------RRtR--------D--SMPALYEQTRiymk 195
XP_003454910 493 PLS----KSS----LDN----------YEDYDGsvPH-----ITA------AH-S--------H--HGRG-WDEDSvvss 531 Nile tilapia
Q98SJ5       496 PLP----KSS----PEN----------GDSFEGvsPH-----IAS------IH-S--------L--QVRGHWDEDSavss 535 zebrafish
XP_023187120 489 PLS----KRY----LDN----------HDGYNSslAS--------------ISaI--------QskQGRAHWEEDSivss 528 southern platyfish
XP_031134248 499 PLS----KSSlenhEGY-------------------DssvpqITA------IH-S--------Y--NGRGHWDEDSvvss 538 pike-perch
XP_023414856 499 PSSpspaKNL----PEPpvnia-rhglMPNYEG--GS-----CSHrppprgRFgEdaapppppPp-PPPPSFPSCGhyre 565 African savanna...
XP_015205072 541 p--dpgsaSDSGDRYRSDHFQSSPHEPSKIETLIRATQQMIKEEeSRLQL--------------------RKAN-QDHla 597 spotted gar
XP_003763442 547 --------AAIPNSQQKDVYDSSILKSNKVESRIHPPHHLIKEE-NKLTFngdipekmnahekpslnfvpNSLLpKSEc- 616 Tasmanian devil
XP_020926626 554 e--palgpAKAARQAARDGARLALTGPA-PECCAPPAPEPPGAP-AQLPFvll---------------nyHRVLaRRGpl 614 pig
Q61079       553 e--palgpAKAPRQASRDAARLALARAP-PECCAPPAP-EPQAP-AQLPFvll---------------nyHRVLaRRGpl 612 house mouse
7_pfamImport 196 epkygpigHHTPHSDQLDGNNIMMAKVNHDS---ESEHTMEMQPtGQVPFvll---------------nyHHLLsKHGt- 256
XP_003454910 532 p--dggsaSDSGDRYRADHYRCSPQEPSKIETLIRATQQMIKEEeSRLQL--------------------RKGPtPEAsl 589 Nile tilapia
Q98SJ5       536 ap-dggsaSDSGDRFRADQCRSSPQEPSKIETLIRATQQMIKEEeSRLQL--------------------RKLP-TDVpl 593 zebrafish
XP_023187120 529 p--ggdsvSDSGDLYQADHHSCSPEEPNKIETLIRATQQMIKEEeNQMQL--------------------RKSF-ENTpp 585 southern platyfish
XP_031134248 539 p--dggsaSDSGDRYQADHYRCSPQEPSKIETLIRATQQMIKEEeSRLQL--------------------RKGP-PDApl 595 pike-perch
XP_023414856 566 e--talgpAKTARQAARDGARLGLARTPAPECCPPPAE-PPAAPaAQLPFvll---------------nyHRVLaRRGpl 627 African savanna...
XP_015205072 598 plngvakthsscfgtdfpqtqpqgvvcrgpavtssalcdhlqhrdrkmISPHdneqdnSPTSLSRIs------SP----- 666 spotted gar
XP_003763442 617 ------------------------------------------------FQPK------TLGQLSHL-------LP----- 630 Tasmanian devil
XP_020926626 615 ggaapaapala-------------------------cgpgvpeaaagaLRPR------PPGPAAAAaaasppgAP----- 658 pig
Q61079       613 gsaapg-----------------------------------apeaagsLRPR------HPGPVAASap----gAP----- 642 house mouse
7_pfamImport 257 ------------------------------------------------FQPS------SCAATRHVaenygssSEevntf 282
XP_003454910 590 gpanglpkdpgscftpe------------ytqgplplqtmlcrglsqvISPTp-----SPAPQSKLn------SP----- 641 Nile tilapia
Q98SJ5       594 eptnslaksfhstdf-----------------pqsamqsvvcrgpaqvISPAp-----SPVPLSRLs------SP----- 640 zebrafish
XP_023187120 586 gianelhrgaasgfts--------------eytqrslqtmvcrsfsqvISPAf-----SPTPLSRFs------SP----- 635 southern platyfish
XP_031134248 596 gpanglpkgpgpcftpe------------ytqgplplqtvvcrglsqaISPAp-----SPAPLSRLs------SP----- 647 pike-perch
XP_023414856 628 ggaataapgla-------------------------cgpggpeaaagaVRPR------PLSPHSASpp----gAP----- 667 African savanna...
XP_015205072 667 ---SS 668 spotted gar
XP_003763442 631 ---VP 632 Tasmanian devil
XP_020926626 659 ---LP 660 pig
Q61079       643 ---RP 644 house mouse
7_pfamImport 283 iskNP 287
XP_003454910 642 ---GS 643 Nile tilapia
Q98SJ5       641 ---LP 642 zebrafish
XP_023187120 636 ---SA 637 southern platyfish
XP_031134248 648 ---GP 649 pike-perch
XP_023414856 668 ---LP 669 African savanna elephant
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap