Conserved Protein Domain Family
Prokineticin

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pfam06607: Prokineticin 
Prokineticin
This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.
Statistics
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PSSM-Id: 148298
View PSSM: pfam06607
Aligned: 7 rows
Threshold Bit Score: 124.494
Threshold Setting Gi: 297670855
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002813568   1 MR-SLCCAPLLL----LLLlppllltpRAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKn 75  Sumatran orangutan
Q2XXR7         1 MR-SLLCAPLLL----LLL--------SAGESAVITGACDKDLQCGEGMCCAVSLWIRSIRICTPLGSSGEDCHPLSHK- 66  lace monitor
OCT83449       1 MK-KVQCALLLVaavsLLL--------DSGAAAVITGACEKDQQCGGGMCCAVSIWIRSLRMCTPLGNEGDDCHPLSHK- 70  African clawed ...
NP_001099168   1 MS-RVLILCLLL----LSM--------SCCRGAVITGACDRDVQCGVGLCCAVSLWLRGLRMCTPQGLEGDECHPYSHK- 66  zebrafish
Q4RVU3         1 MGfRAVLLSFLL----VSL--------SWSRGAVITGAREKHMQCGLFLFCSVSLLLRGLRMCAPRGLEGDECYPFSHK- 67  spotted green p...
EAW56449       1 MR-GATRVSIML----LLV--------TVSDCAVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHK- 66  human
Q8JFY2         1 MK-CFAQIVVLL----LVI--------AFSHGAVITGVRDRDAQCGSGTCCAASAFSRNIRFCVPLGNNGEECHPASHK- 66  large-webbed be...
XP_002813568  76 nfgngrqerrkrkrskrkkeVPFFGRRMHHTCPCLPGLACLRTSFNRFICL 126 Sumatran orangutan
Q2XXR7        67 --------------------VPFDGQRKHHTCPCLPNLVCGQTSPGKHKCL 97  lace monitor
OCT83449      71 --------------------IPYFGKRMHHTCPCFPNLTCIKLDDSIYKCL 101 African clawed frog
NP_001099168  67 --------------------VPFPGKRQHHTCPCLPHLVCTRYADNRYRCT 97  zebrafish
Q4RVU3        68 --------------------VPYPGKRQHHTCPCLPHLMCTRFEDSKYRCT 98  spotted green pufferfish
EAW56449      67 --------------------VPFFRKRKHHTCPCLPNLLCSRFPDGRYRCS 97  human
Q8JFY2        67 --------------------VPYNGKRLSSLCPCNTGLTCSK-SGEKYQCS 96  large-webbed bell toad
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