Conserved Protein Domain Family
JHBP

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pfam06585: JHBP 
Haemolymph juvenile hormone binding protein (JHBP)
This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph. The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organisation of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance. This family now includes DUF233, pfam03027.
Statistics
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PSSM-Id: 399529
View PSSM: pfam06585
Aligned: 232 rows
Threshold Bit Score: 111.916
Threshold Setting Gi: 195164770
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O76879                8 MFLVWVGLLSwvscrvdASEGFPSPL-KRCKLQD------ESCLLAQAQTFFQAFKNGI-PERQVAALEPIALGTMFIEs 79  fruit fly
ETN59354              9 ALMALTATGV------------N----EVAGQNii----lDAIMRRILENLRELMRTGN-PETGMPVLAPYNNPDLFIN- 66  Anophele...
ETN59353              9 AMVAVLSNAA---------VIVPR---EPAPRTt-----lNEALAQLLENIRELLRTGD-PERGLPVLAPLQTDRLDVD- 69  Anophele...
Q29K83                9 VALLCCSLGS------------S-KL-----FDD--------QLRELTEFLRLQMRCGY-PPRGVPVLAPAQIAYQQVA- 60  Drosophi...
Q9V3H6                9 VALLCCSLGS---------AKL---------FDD--------ELRELTEFLRLQMRCGY-PARGVPILAPAQMAYKEIGi 61  fruit fly
WGS:AANI:GJ22799-PA   9 ALLVVVASAS------------P-----VTQ--DtsmvnyGEAVEMFLDAWKKMLPCGYaPD-NIPVMAPLTVDFYAFD- 67  Drosophi...
EDV91489              9 TLLVAVASAT------------P-----VTQ--DtsmvgyREAMDMFLDAWKKMIPCGF-PSENIPVLAPLTTDFYAFN- 67  Drosophi...
WGS:AAQB:GK12165-PA  10 ALLVATASAT------------P----ITIGTGvn----fGQAMYKFLTAFKSIMPCGY-AAEGIPVMAPLVTEFQSFS- 67  Drosophi...
EDX15174             12 LLALTVVNAN------------P-VVqQAASaq------fTSAVSRFLRAFKSIMPCGY-GDL--PVMSPIVSPFYEFE- 68  Drosophi...
XP_551486             9 ALFVVASNAAti----pHQPSRPEALaPEQRat------lDEALAQLLENIRELLRTGD-PERGIPVMAPLETDRLDVD- 76  Anophele...
O76879               80 GGhSesiKFKLTMSDAKLYNLaNS----MMVKSLKGFTKDltRPlkLTLLLDNPELEV-RAKYDVD--GKL----LIL-- 146 fruit fly
ETN59354             67 ASfGgllDFDARFTPMNIVGL--D----TFVGRLQVDLAS--LR--FPFEFRFDELTA-SGFYDAN--GRL----WGLi- 128 Anophele...
ETN59353             70 LSlGgllDFTAILNNLYLDGL-DR----F-QGTLTLNVML--ME--FTYDFLFPDLLA-RGQYDAD--GRL----FGLi- 131 Anophele...
Q29K83               61 IAtEs-lGCRGNFTELTLEGL-DG----YEFAKLE--WNNilHT--IKFDINFPRVSVrSSKYMLDilARL----FGS-- 124 Drosophi...
Q9V3H6               62 RTen--fGCNGNFTDLIIEGL-DG----YEFSKLE--WNNilHT--IKFDMNFPKISLkSTNYKLNllARL----FGAd- 125 fruit fly
WGS:AANI:GJ22799-PA  68 YN-NgetNIVGNVSNIRISGL-NN----FQVLSGSFNPNT--LR--STYDVLYPEIQI-FGSYEVE--GVI----SIAgf 130 Drosophi...
EDV91489             68 YN-NgetNLVGNVSNIRISGL-NN----FQVLSGSYDPTT--LR--ATFDVLFPELQI-LGSYEVE--GTVgiggLPL-- 132 Drosophi...
WGS:AAQB:GK12165-PA  68 YEsDndySISGNVSNINIIGL-NN----FHILDGSYDASS--QH--ANFDLIFPEIQI-LGAYEVE--GFV----SIGgi 131 Drosophi...
EDX15174             69 HI-SedfTVVGNVTNIRIQGL-DG----FQVLSASDYGKT--GE--AAYDVLFPKIQV-LGFAEID--GFI----NIGgf 131 Drosophi...
XP_551486            77 LSlGgllDFTAILRNLFVDGL-DRfqgtLTLNVMQ-------ME--FRYDFLFPDVVA-RGHYDAN--GRL----FGLi- 138 Anophele...
O76879              147 --PIV--SKGDLTIRLNDVHTKVWITAE--PVKRsDGHTYLNITDYKTATKIKGG-HFDLSNLFN-D-NKELRDSTLKVL 217 fruit fly
ETN59354            129 --PVF--GIGDFTVRPRNVLATGFATIT----DN--GQGFLMLSDFSISLQMDAL-DSNIQGLLL-G--GDLSVLLNAVL 194 Anophele...
ETN59353            132 --PVF--GFGNFNVQPRNLRIQGTAQIRqlPS------GYLHMTELKANVRLGSL-QNNIEGMLL-G--GELSDLLNAVI 197 Anophele...
Q29K83              125 --DFAlwGDGVFSLELIDFRAHGSFVIR--PT---TASSGVYVKSWQVNWQLGEA-RSQTTGIMN---SRLYTKFVNDLV 193 Drosophi...
Q9V3H6              126 -fSLW--GDGALSLELINFRAYGSFVIRp-KS----ATSGVYAKSWKVNWELEEA-KSQTTGFMN---SRLYTKFINDLI 193 fruit fly
WGS:AANI:GJ22799-PA 131 pvPIR--QSVLINKKLTDWRFVGDYTFA--QSLS--NSNGLRISDFNLHYFVGDVkVDNWDKYLDiAaN----NYFNDIF 200 Drosophi...
EDV91489            133 --PIR--QSVLINKKLSDWRFVGDYTFA----QSlSNSNGLRLADFNLQYFVANVqAANWNKFMDiAtN----NYFNSFI 200 Drosophi...
WGS:AAQB:GK12165-PA 132 hlPIN--QNSLLNEKLEDLRFVGSYNIE--SN----NSSGLQLTDVKIEIYLGDFkLENWNSLWSvAaN----EFANDYG 199 Drosophi...
EDX15174            132 kvPIQ--QNDVINEALVDLRFVGSYSFD--NSLT--NSSGLRMVNFRQTIYLAGVeFDNWNTLWNiStN----NFWNRLM 201 Drosophi...
XP_551486           139 --PVF--GLGNFHVAPRDLRIQGTALLR--QL----PSGYLHMPELKANVRLGSL-QNNIEGMLL-G--GELSDLLNVVI 204 Anophele...
O76879              218 NQEWSTLALDVQPKINEACAKAFSA-IVQSLWANIPYDEFFE 258 fruit fly
ETN59354            195 QDIVPSILRNFPDGMTNLLNALVVP-IANRFLATRTMEDLMG 235 Anopheles darlingi
ETN59353            198 QDLVPSVLVNFAPEVTDIISRVGIP-IADSILNTMTLDDLFG 238 Anopheles darlingi
Q29K83              194 KDYLELLVNDNPAEVSQFMEGLIVP-PLNAVLENVAWYEITA 234 Drosophila pseudoobscura
Q9V3H6              194 VEYLDIMINDNPTEVSQFMEELIVP-PMNLVLDNLAWYEITA 234 fruit fly
WGS:AANI:GJ22799-PA 201 GSFSLLFTQEIQPYIKPFYGKYVLP-SINNMLSNLSLTQLAD 241 Drosophila virilis
EDV91489            201 NSFSLLFTEEIQPYVNPMLEKYLLP-TINNLLSNVDMTQLTN 241 Drosophila grimshawi
WGS:AAQB:GK12165-PA 200 SAFLNYVIAEYRGDIGNLYSQLVVS-EYNKLLANVNLSQVID 240 Drosophila willistoni
EDX15174            202 QSLLPLALEEIQPNITNILYQNFFVpKINDLLANVSMSELVS 243 Drosophila simulans
XP_551486           205 QDLIPSVLINFAPEVTDIISRVGIP-IADSVLNTMTLEDLFA 245 Anopheles gambiae str. PEST
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