Conserved Protein Domain Family
DIRP

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pfam06584: DIRP 
DIRP
DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.
Statistics
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PSSM-Id: 399528
View PSSM: pfam06584
Aligned: 42 rows
Threshold Bit Score: 111.146
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:OSTLU_27481                331 FTAGTDKGWFEDSGFSRWLQHIGKG-DMRVATREEWQKVRRKLPKTRRLSLKFLKDERVDLEYFRHAAREMTNLklhgtv 409  Ostreococcus lucimarinus CCE9901...
EFJ16240                       372 FYSAIDLPWFARNEFVEYLNHAGLG-HVSKLTRTEWTVIRSSLGKPRRLSQKFLQVEREKLEAYRDTVRAHYHDi----- 445  Selaginella moellendorffii...
XP_018684196                   588 FYSAIDYPWFAKNDYVEYLNHARLS-HIPRFRRAEWSIIRRSLGKARRFSNKFLSEERMKVEQYRESVRTHYTE------ 660  wild Malaysian banana...
RID64433                       705 FYSAIDHPWFAKMEFVDYLNHVGLG-HIPRLTRLEWSVIKSSLGRPRRFSERFLQEEREKLKQYRESVRKHYTE------ 777  field mustard...
KRH33931                       626 FYSAIDYPWFAKREFMEYLNHVGLG-NIPRLTRVEWSVIKSSLGKPRRFSEHFLCEERQKLEQYRESVRKHYTE------ 698  soybean...
RVW53166                       196 FYSAIDYPWFVKKEFVEYLDHVGLG-HIQRLSRVEWDVIRSSLGKPRRFSERFLHEEKEKLKQYRKSVRTHYTE------ 268  wine grape...
EFN59185                       256 cYSALDRPFFMFNPLAGLLAQLGLG-EGARLTRREWCLIRSSLGKPRRLSLKFLKEERVRLERWRDGCRQQYQSg----- 329  Chlorella variabilis...
A0BQT2                         161 FYSHLDYTYFSLNEFQQMLTKASIPlGSKS--IAEWRIIKMAVGQPRRFSFYFLQQEMSKLTKYRSVIRNYLFDqny--- 235  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00591560A  300 FYSTIDKPFFQFNEFKEMLAKVGLE-NIGKLTRAEWNIIRKAMGKPRRFSNEFVRGELKKLEIYRKIVREYLQTqqa--- 375  Tetrahymena thermophila SB210...
BAF01889                        45 FYSAIDYPWFARQEFVEYLDHVGLG-HVPRLTRVEWGVIRSSLGKPRRFSEQFLKEEKEKLYLYRDSVRKHYDE------ 117  thale cress...
jgi:OSTLU_27481                410 ltdELKALmLKWTGGvpVPSPLEVGQTVLAVHP 442  Ostreococcus lucimarinus CCE9901
EFJ16240                       446 ---RNDKSgCCLPPD--LARPLTVGQRVIARHP 473  Selaginella moellendorffii
XP_018684196                   661 ---LLAGTtKGLSRD--LAIPLSVGQHVIACHP 688  wild Malaysian banana
RID64433                       778 ---LRTGArEGLPTD--LARPLAVGNRVIAIHP 805  field mustard
KRH33931                       699 ---LRTGIrDGLPTD--LAKPLYVGQHVIALHP 726  soybean
RVW53166                       269 ---LRTGArEGLPRD--LARPLSVGQRVIALHP 296  wine grape
EFN59185                       330 ---AAAVAhPKVADH--LPLPLGVGQRVVARHP 357  Chlorella variabilis
A0BQT2                         236 -piHRDIRnLDLIHDivRLAPFNVDQTVYAVHP 267  Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00591560A  376 -hvLRSKIrESLSEEimRIQPFKVGQIVMGIHP 407  Tetrahymena thermophila SB210
BAF01889                       118 ---LNTGMrEGLPMD--LARPLNVSQRVICLHP 145  thale cress
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